Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The excess incidence of schizophrenia reported from Ireland may partly be due to the unusual distribution of the irish population by maternal age at birth.
Br J Psychiatry 1977 Sep
PMID:Maternal age and incidence of schizophrenia in the Republic of Ireland. 91 30

The possible interrelation of schizophrenia and alcoholism was examined by comparing schizophrenic adoptees and their biological relatives with control adoptees and their biological relatives. Neither schizophrenics nor their relatives had higher rates of alcoholism than did controls.
J Stud Alcohol 1977 Sep
PMID:Alcoholism in schizophrenics and their relatives. 91 95

The mortality and prevalence of ALS in the various countries of Finland was studied. The work was based on death certificates derived from a 10-year period from 1963 to 1972, and altogether 421 cases were found. The mean duration of the disease was 2.7 years, and the mean age at death was 61.2 years. The average annual mortality rate was 0.91 per 100,000. The male to female ratio was 0.87 to 1, males outnumbered females only in age groups under 65. Some clustering of the cases seems to be taking place in the south-eastern part of the country. The rural to urban distribution of the patients' places of birth and domiciles did not differ markedly from that of thw whole population. After ALS itself pneumonia was the most common direct cause of death. Of other significant conditions coded in the death certificates schizophrenia and cancer did not occur more often than could be expected by chance. No evidence of inheritance of the disease was found.
J Neurol Sci 1976 Sep
PMID:The epidemiology of amyotrophic lateral sclerosis in Finland. A study based on the death certificates of 421 patients. 95 May 75

Chapman and Chapman (Disordered Thought in Schizophrenia, Appleton-Century-Crofts, New York, 1973) have suggested that findings of abstract thinking deficits in schizophrenia could be functions of control task artifacts. This paper describes two projects in which the abilities of schizophrenics and psychiatric hospital controls who had been closely matched on a wide variety of vocabulary and nonvocabulary control tasks to perform several types of abstract thinking tasks were compared. No differences on the mean scores of the schizophrenic and control patients appeared on four of five measures used. On the fifth, a logical reasoning test, the schizophrenics were inferior to controls. The results suggest that many of the differences reported earlier between schizophrenics and nonschizophrenics on abstraction tasks may result from the heavy reliance of researchers on vocabulary as a control matching test, and its peculiar resistance to deterioration in schizophrenia. The results also suggest that inability to use logic properly may be.
J Nerv Ment Dis 1976 Sep
PMID:A comparison of abstractive and nonabstractive deficits in schizophrenics and psychiatric controls. 95 3

In a number of reports, Gruzelier and Venables have demonstrated that about 50% of the schizophrenic population do not show the skin conductance orienting response (S.C.O.R.), while those that do respond, do not show normal habituation. Zahn (Orienting response in schizophrenics. J. Nerv. Ment. Dis., 162: 195-199, 1976) has questioned the bimodality of the S.C.O.R. in schizophrenia and suggests that responding/nonresponding could well be due to differential effects of phenothiazine medication. In two experiments (with equally medicated patients), in two different hospitals, the present report confirms the finding of a large proportion of nonresponding in schizophrenia but also suggests that both normal and nonhabituation are seen within schizophrenics and normals. Differential pupillary dilation and constriction parameters are seen in responders and nonresponders although both of these patient groups show tachycardia (the most usual effect of phenothiazines) in comparison to the normal group. The results do not fit easily into the differential effect of phenothiazines hypothesis proposed by Zahn.
J Nerv Ment Dis 1976 Sep
PMID:Skin conductance responding/nonresponding and pupiliometrics in chronic schizophrenia. A confirmation of Gruzelier and Venables. 95 4

Review of the literature concerning the relationship between deafness and psychiatric disorder reveals differences in the pattern of illness depending on the severity of deafness and the age of onset. In particular, the prevalence of schizophrenia in the prelingually deaf is similar to that found in the normal population, whereas the hard of hearing are over-represented among samples of patients suffering from paranoid psychoses in later life. Possible modes of action of long-standing hearing loss in the aetiology of paranoid illnesses are considered: the psychological and social consequences of deafness, the possible contribution of sensory deprivation phenomena, and the interference of hearing loss in attention, perception and communication. Finally, possible future lines of research are suggested.
Br J Psychiatry 1976 Sep
PMID:Deafness and psychiatric illness. 96 55

Monoamine oxidase (MAO) is an important enzyme in the catabolism of brain biogenic amines. Platelet MAO has been reported to be moderately reduced in manic-depressive patients and markedly reduced in schizophrenic patients. This enzyme's activity has been shown to be under a large degree of genetic control and has been proposed as a 'genetic marker' in schizophrenia. A transcultural replication of the finding of low platelet MAO in schizophrenia and manic-depressive illness was carried out at the Jerusalem Mental Health Centre. Manic-depressive patients were found to have higher platelet MAO activity than schizophrenic patients, as reported previously, but control individuals were as low as the schizophrenic patients. It is unlikely that platelet MAO activity is a transculturally-valid marker for schizophrenia.
Br J Psychiatry 1976 Sep
PMID:Platelet monoamine oxidase in schizophrenia and manic-depressive illness. 96 56

The paper presents data on the differential fertility of schizophrenics and controls, and the fertility of their siblings. This study used several methodological procedures in the study of schizophrenia reproduction, which strengthens the validity of the findings. Firstly, both male and female rates were examined. Secondly, the method of selection of a control avoided the biases introduced by using census data or other non-matched controls. Third, a diagnostic criterion was used which minimizes the possibility of the inclusion of other psychiatric illnesses. The results obtained support prior reports of the lowered reproductive rates of schizophrenics. Further, the siblings of schizophrenics were found not to have a reproductive advantage when contrasted to control siblings. The failure to find a reproductive advantage conflicts with a hypothesis of a balanced polymorphism as the mechanism maintaining an apparent constant rate of schizophrenia.
Acta Psychiatr Scand 1976 Sep
PMID:Differential fertility of adopted schizophrenics and their half-siblings. 97 Jan 92

This is a succint description of the International Pilot Study on Schizophrenia, sponsored by the World Health Organization and conducted in field research centers located in 9 different countries. The main objective of this study was the development of standard procedures for case finding, assessment of damage caused by Schizophrenia and observation of the course and outcome of the disorder. Starting in 1968, groups of approximately 120 patients who met the criteria both for inclusion and exclusion were studied in each center. They were subject to study by means of several instruments and were given a clinical diagnosis. On that basis, comparative analysis within and between centers were conducted, as well as reliability tests for the procedures used. Two follow-ups took place at 2 and 5 year intervals in order to obtain information about the course and outcome of cases. The emphasis of this presentation is placed on the findings at the Cali (Colombia) field reserach center and their comparison with the global results of centers in the rest of the world. In that context, the findings show that centers in developping countries are at least as capable for conducting research work as those in the developped countries. There is also the suggestion that mental disorders in developping countries apparently tend to more benign course and outcome.
Acta Psiquiatr Psicol Am Lat 1976 Sep
PMID:[International pilot study on schizophrenia, its implications for Latin America]. 98 47

The difficulties of regular drug intake in long term treatments for psychotic patients gave rise to the need of using medicines at the longest possible intervals, facilitating thus adequate control and regularity. Penfluridol is a neuroleptic meeting that requirement: it is necessary only one dose per week. This paper reviews the results of Penfluridol in 26 patients (20 inpatients and 6 outpatients), ages between 17 and 54 with a mean of 36.8, sex feminine, and the following diagnoses: schizophrenia, paranoid: 14, simple: 8, hebephrenic: 3, catatonic: 1. The patients, divided in two groups of 13 each, had one oral dose a week, of between 10 and 100 mg, during 90 days. The first group took only Penfluridol, suppressing any other medicaments. The other group added Penfluridol to the prescriptions already in use. The results, as described in tables I and II, were evaluated according to 36 items. The general evaluation was positive with no negative biases. The side effects were scarce and temporary: insomnia in 7 cases during the first week, and extra-pyramidal symptoms in another 7 cases, that were controlled with antiparkinsonians. The conclusion is that Penfluridol is a valuable contribution to longterm treatments in psychoses.
Acta Psiquiatr Psicol Am Lat 1976 Sep
PMID:[Activity of a new neuroleptic, penfluridol (R-16341) in long-term treatments]. 98 50


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>