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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Clinical experimental research on schizophrenia does not consider maturation processes of brain function in the majority of cases. In the course of neuronal organization and the differentiation phases of cerebral systems, early traumas in functionally important regions of the brain are accompanied by a facultative impairment of complex systems of information processing. Against the background of the comprehensively coherent "integrative psychobiological model of schizophrenia" (Ciompi) with high construct validity, (experimental) psychology investigations are reported on in the context of the "high-risk" concept in 44 young (20-37 years old) and mainly chronic schizophrenic patients with formation of a specific hypothesis for the developmental biology of the condition. In two homogeneous groups with the same structure, it is checked whether a discriminative appraisal concerning a different organization principle of central information processing systems is possible with "crossmodal" choice-reaction times (cCRT) and certain subscales of the Frankfurt symptom questionnaire (FBF) with regard to alternatively distributed and specially operationalized anamnestic biological risk factors. It can be objectively established in terms of experimental psychology that postpsychotically de-actualized "risk-free" schizophrenics differ from the reference group with a high-risk anamnesis in terms of significantly prolonged cCRT, but not from healthy subjects and an "MBD" control group. In addition, the FBF subscores "weakness of selective attention" and "loss of automatized skills" correlate with poor cCRT.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:["Modality shift" paradigms and subjective basic symptoms in schizophrenic patients with various developmental biological risk anamnesis]. 169 Apr 50

The authors present the preliminary results of the third version of the Frankfurt Psychopathological Inventory (FBF-3) in a sample of consecutive schizophrenic inpatients. They were 64 patients who had the RDC and/or DSM-III-R schizophrenic criteria. Forty-three patients fulfilled the FBF-3 and were the scope of this study. There were not influences in the results of FBF-3 in relation to epidemiological and clinical variables, with the exception of the sex and lack of insight variables. The results were analyzed and compared with the previous studies in the literature. It is suggested its relations with theoretical and etiopathogenic models of schizophrenia.
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PMID:[Cognition disorders in schizophrenia: evaluation using the Frankfurt psychopathologic inventory (FBF-3). Initial results]. 280 Dec 67

The results of a study on the subjective basic symptoms associated with schizophrenia and drug abuse (especially alcoholism) are presented. A total of 242 psychiatric inpatients (74 with a dual diagnosis of schizophrenia and drug consumption, 81 schizophrenics, and 87 alcoholics) were included. The three groups did not differ with regard to the general score of subjective basic symptoms measured by the Frankfurt Complaint Questionnaire (Frankfurter Beschwerde-Fragebogen, FBF). Further analyses showed that the FBF statements are only partly typical for schizophrenia; another part is connected with alcoholism. Two new scales ("FBF-S" and "FBF-A") were created from the schizophrenia-typical items and the alcoholism-typical items, respectively. In "FBF-S" schizophrenics (with and without alcoholism) had higher scores than patients suffering from alcoholism alone; in "FBF-A" alcoholics (with and without schizophrenia) reached higher scores than schizophrenic patients. Consistent correlations with independent parameters of psychosis and alcoholism confirm the validity of "FBF-S" and "FBF-A". It is concluded that the FBF's capacity to discriminate different diagnoses can be improved and that the model of basic disturbances must be re-evaluated.
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PMID:[Basic symptoms in schizophrenia and alcoholism. A methodological comparative study]. 760 13

This review deals with the opinions and findings of the last six decades regarding occurrence, frequence, and phenomenology of precursor stages of schizophrenic and schizoaffective psychoses. Already in his classical delineation of the onset of schizophrenia Mayer-Gross (1932) differentiated between uncharacteristic and characteristic precursors of schizophrenia and anticipated essential aspects of the concept of basic stages and basic symptoms which has been gradually developed by clinical psychiatrists and psychologists since the 50s. In his monograph "The beginning schizophrenia" Conrad (1958) resumed the "promisingly undertaken, but prematurely coming to a standstill" work of the descriptive-phenomenological psychopathology of the Heidelberg School (Jaspers, K. Schneider, Mayer-Gross, Gruhle) and investigated systematically early abnormalities of behaviour with the method of morpho-analysis. However, the study of Conrad refers already to the onset of the first psychotic episode, the "trema" which is not identical with the outpost syndromes and prodromes in the sense of Mayer-Gross and the authors of the basic symptom concept. The "trema" is characterized mainly by disorders of behaviour and expression, the precursor syndromes by dynamic and cognitive basic deficiencies, experiential and not behavioural in kind, typically only recognizable by the self-reports of the patients. The ability of recognition and realization of the basic symptoms as complaints and disorders and to develop coping strategies was the presupposition for a standardized survey and assessment of basic symptoms in the Frankfurt Questionnaire (FBF) and the Bonn Schedule for the Assessment of Basic Symptoms (BSABS).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Prodromal symptoms in schizophrenia]. 775 51

A study on the concept and measurement of the basic disorders of schizophrenia is presented. A total of 151 male adult psychiatric inpatients (51 with a dual diagnosis of schizophrenia and alcoholism, 50 schizophrenics and 50 alcoholics) were included. The aims of this study were: (1) the replication of the previous finding that the Frankfurt Complaint Questionnaire (FBF) contains items that discriminate between schizophrenia and alcoholism; (2) an empirical comparison between FBF and the Bonn Scale for the Assessment of Basic Symptoms (BSABS); (3) testing the relationship between basic and negative versus positive symptoms, as measured by the Positive and Negative Syndrome Scale (PANSS). Regarding (1), the former result was replicated. Regarding (2), FBF subscales and BSABS categories were shown to be significantly but weakly related, even if identical symptoms were included in the inquiry. Regarding (3), FBF and BSABS were found to be more closely related to negative than to positive PANSS items. Theoretical implications and consequences for further research are discussed.
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PMID:[Validity of assessment of schizophrenic basic symptoms]. 919 80

Among the reasons for the relatively limited number of investigations of self-knowledge phenomena should be included, in addition to theoretical motives, the difficulties regarding the use of instruments available for this kind of approach and their content validity. This study investigates the relationship between subjective and objective deficits in schizophrenia, taking into account subjective experiences of cognitive impairment, clinical symptoms, and cognitive evoked potentials (P300 component). A group of 36 young schizophrenic patients (29 on neuroleptic treatment and seven drug-naive) were considered, together with a comparison group of 36 healthy subjects. Auditory event-correlated potentials (ERPs) were obtained using a simple "oddball" paradigm. Clinical symptoms were rated with the Brief Psychiatric Rating Scale (BPRS) and Scales for the Assessment of Positive and Negative Symptoms (SAPS and SANS), and while subjective disturbances were assessed by the Frankfurter Beschwerde Fragebogen (FBF, also called the Complaint Questionnaire). Correlation analysis showed that P300 amplitude was inversely correlated with subjective experiences of cognitive deficit, especially in the area of automatic skills and overstimulation. No relationship emerged between BPRS, SANS, and SAPS scores and P300 alterations. The results suggest that subjective cognitive disturbances, more than objective symptoms, are related to P300 alterations in schizophrenia, and that the FBF questionnaire appropriately covers the domain of schizophrenic cognitive disorders.
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PMID:Basic symptoms and P300 abnormalities in young schizophrenic patients. 1050 19

Bipolar patients often experience subjective symptoms even if they do not have active psychotic symptoms in their euthymic state. Most studies about subjective symptoms are conducted in schizophrenia, and there are few studies involving bipolar patients. We examined the nature of the subjective symptoms of bipolar patients in their euthymic state, and we also compared it to that of schizophrenia and normal control. Thirty bipolar patients, 25 patients with schizophrenia, and 21 normal control subjects were included. Subjective symptoms were assessed using the Korean version of the Frankfurter Beschwerde Fragebogen (K-FBF) and the Symptom Check List 90-R (SCL90-R). Euthymic state was confirmed by assessing objective psychopathology with the Positive and Negative Syndrome scale of Schizophrenia (PANSS), the Young Mania Rating Scale (YMRS), and the Montgomery Asberg Depression Rating Scale (MADRS). K-FBF score was significantly higher in bipolar patients than in normal controls, but similar to that in schizophrenia patients (F=5.86, p=0.004, R2=2033.6). In contrast, SCL90-R scores did not differ significantly among the three groups. Euthymic bipolar patients experience subjective symptoms that are more confined to cognitive domain. This finding supports the hypothesis that subtle cognitive impairments persists in euthymic bipolar patients.
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PMID:Experience of subjective symptoms in euthymic patients with bipolar disorder. 1830 93