Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Performance on the Letter-Number Sequencing (LNS) and Wisconsin Card Sorting Tests (WCST) have been shown to be significantly correlated in patients with schizophrenia, a relationship postulated to be due to working memory demands of the two tests (Gold, Carpenter, Randolph, Goldberg, & Weinberger, 1997). An alternative explanation for the association between these two tests is their sorting demands, in that both require sorting of information albeit in slightly different ways. If the latter explanation is valid, then working memory tasks that do not require sorting or other conceptualization demands should be less predictive of WCST performance than LNS. These hypotheses were examined in 34 poor outcome patients with schizophrenia, one-half of whom were over the age of 65. Patients were evaluated on Digit Span Forward, spatial working memory, LNS, and the WCST. It was found that WCST performance was significantly associated with performance on the LNS but no other working memory task. Age related performance differences were greatest on the WCST Categories and floor effects were noted on this test in one-half of the subjects. Analyses predicting WCST Categories in subjects whose scores were greater than zero (n = 16) also demonstrated that LNS, but not Digit Span or spatial working memory (any delay) predicted WCST performance. These findings indicate that LNS may be an index of executive functioning, particularly in patients who cannot perform the WCST.
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PMID:Working memory performance in poor outcome schizophrenia: relationship to age and executive functioning. 1520 35

The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS; Randolph, 1998) is a screening battery designed to measure attention and processing speed, expressive language, visual-spatial and constructional abilities, and immediate and delayed memory. Clinical normative data for a large sample of inpatients and outpatients with schizophrenia spectrum disorders is available (Wilk, Gold, Humber, Dickerson, Fenton, & Buchanan, 2004). The purpose of this study was to replicate and extend the clinical normative data for the RBANS for use in inpatient psychiatry. Participants were 174 inpatients from a provincial psychiatric hospital with a diagnosis of schizophrenia spectrum disorder. Median performance on the RBANS was 1-2 standard deviations (SDs) below the mean. Patients with more than 12 years of education performed significantly better on every index score than patients with 12 or fewer years of education. Men performed better than women on the Visuospatial/Constructional Index (Cohen's d= .47). When examining all five Index scores simultaneously, it was common for inpatients to obtain three or more frankly impaired scores (i.e., less than the 2nd percentile). Overall, the performance of this inpatient sample was very similar to the clinical normative data presented by Wilk et al. (2004). Detailed normative tables by diagnosis, education, and gender are provided.
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PMID:Interpretation of the RBANS in inpatient psychiatry: clinical normative data and prevalence of low scores for patients with schizophrenia. 1920 46