Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Seclusion is a common treatment method in psychiatry. However, there are contradictory reports about the effects of the sensory deprivation involved in seclusion on the distortions of perceptions seen in some psychiatric patients. This descriptive study explored the seclusion experiences of seriously ill psychiatric patients; described the hallucinatory experiences of these patients during seclusion; and examined the relationship between hallucinations and sensory stimulation, as reflected in staff visits and length of time secluded. Consenting adult male and female psychiatric inpatients (n = 25), with DSM III-R diagnoses of schizophrenia or schizoaffective disorder were interviewed within 5 days after a seclusion experience, using a modification of Richardson's structured interview guide. Approximately half of the patients hallucinated in seclusion; however, 70% of these had also hallucinated before seclusion. There were no significant relationships between hallucinating in seclusion and frequency of staff visits or length of time secluded; however, patients who hallucinated received significantly more "as needed" (PRN) medications and had more therapeutic visits than patients who did not hallucinate.
 ...
PMID:Hallucinatory experiences of psychiatric patients in seclusion. 808 Mar 5

Concomitant medications are frequently used in the treatment of resistant psychiatric conditions to augment the primary psychotropic agent or to ameliorate side effects. The present study evaluated the prescription of concomitant psychiatric medications for psychiatric inpatients that were prescribed either olanzapine at its first commercial availability or another first-line antipsychotic agent. Sixty-nine newly admitted patients (mainly with schizophrenia) who were prescribed either olanzapine (n = 35) or another first-line antipsychotic agent (n = 34) were assessed (for the prescription of other concomitant psychotropic drugs) before (2-4 weeks prior to study) and following 8 weeks of treatment (unless discharged sooner). The results indicate that significantly fewer olanzapine-treated subjects were prescribed anticholinergic agents as compared to those prescribed other first-line antipsychotic agents, and a similar trend was noted in the prescription of mood stabilizers as well. Olanzapine-treated subjects used less as needed (PRN) antipsychotic medication compared to pre-olanzapine treatment period. Olanzapine-treated subjects used more anxiolytic agents compared to the control group in the early stages of treatment, probably due to the greater baseline severity of illness. These data suggest that olanzapine use is associated with less use of anticholinergic and mood-stabilizing agents as compared to older antipsychotic agents. These results also suggest that there is less need for PRN antipsychotic medication following olanzapine treatment. More severely ill subjects may require more anxiolytics during olanzapine initiation. The need for less anticholinergic and mood-stabilizing agent use with olanzapine could lead to greater adherence to long-term treatment and perhaps decreased cost (i.e. use of blood and organ system monitoring with mood stabilizers). At the end of treatment, olanzapine-treated subjects had statistically significantly lesser concomitant medicine usage compared to control subjects.
 ...
PMID:The use of concomitant medications in psychiatric inpatients treated with either olanzapine or other antipsychotic agents: a naturalistic study at a state psychiatric hospital. 1199 92