Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The plasma content of chlorpromazine (CPZ) and its two metabolites 7-OH-chlorpromazine (CPZ-OH) and chlorpromazine sulphoxide (CPZ-SO) were measured in the blood of schizophrenic patients established on chlorpromazine therapy. Administration of the commonly used antimalarial agents chloroquine sulphate, amodiaquine hydrochloride and Fansidar one hour before the first dose of chlorpromazine for the day led to marked increases in CPZ and CPZ-OH over control levels. There were no consistent changes in CPZ-SO levels. The implications of these findings are discussed, first with regard to possible therapeutic relevance for the management of schizophrenia and more particularly, with regard to the possible toxic effects of concurrent administration of antimalarial agents and chlorpromazine.
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PMID:Effects of antimalarial agents on plasma levels of chlorpromazine and its metabolites in schizophrenic patients. 338 14