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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The glucose, lactate, and pyruvate levels, the lactate/pyruvate ratio and pH were studied in serum and CSF of patients with schizophrenia, reactive psychosis, symptomatic or circular psychosis under the effect of atropine coma, ES and pentetrazole convulsions, tranquilizer treatment and combined therapy. Convulsive therapy caused a disorder in cerebral carbohydrate metabolism while no similar changes were induced by atropine coma. Anaerobic carbohydrate metabolism was stimulated by combined therapy. This treatment had the best effect and the changes caused by it were slighter than in the case of convulsive therapy. The changes in EEG frequency corresponded to the biochemical changes.
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PMID:Biological studies on the effects of some therapeutic procedures used in psychiatry. 1

The dopamine hypothesis of schizophrenia proposes that schizophrenia is associated with increased brain dopaminergic function. Because dopamine is thought to stimulate the production of cyclic AMP in the brain, we hypothesized that CSF cyclic AMP would be increased in schizophrenia. Cyclic AMP in the CSF was determined in 19 schizophrenic patients who had not received neuroleptic treatment in the preceding two weeks. No significant difference could be shown between CSF cyclic AMP in these patients and CSF cyclic AMP in 10 psychiatrically normal controls.
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PMID:Cyclic AMP in the CSF of patients with schizophrenia. 18 6

Hemodialysis resulted in remission of psychopathological symptoms in eight of ten chronic schizophrenics and successful hemodialysis was associated with a decrease of leucine endorphin levels in the blood. Three endorphins (endogenous peptides) have been isolated from the brain, and among them beta-endorphin was found to be the most potent in inducing behavioral changes in the rat. Nevertheless, neither a positive, nor an inverse relationship between the severity of schizophrenic psychopathology and CSF endorphin concentrations could be borne out by clinical experiments. Most recently, on the basis of an entirely different line of research, the possibility that schizophrenia is a prostaglandin deficiency disease has been raised.
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PMID:Some recent biochemical findings with possible therapeutic implications for schizophrenia. 20 79

Serum and CSF specimens from 12 schizophrenic patients and 10 non-psychiatric controls were tested for herpes simplex type 1 virus neutralizing antibody and for measles and rubella haemagglutination inhibiting antibodies. There were no significant differences in the distribution of virus antibody titres in serum or CSF specimens between the patients and the controls. The possible aetiological role of viruses or virus-like agents in schizophrenia and some methodological aspects are discussed.
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PMID:Serum and CSF antibody levels to herpes simplex type 1, measles and rubella viruses in patients with schizophrenia. 21

Serum and CSF specimens from 16 schizophrenic patients and 18 nonpsychiatric controls were tested by radioimmunoassay for immunoglobulin G antibody of capsid, envelope and excreted antigens of herpes simplex type 1 virus. There were no significant differences in the antibody levels between the schizophrenic patients and the controls. The etiological role of viruses and virus-like agents in schizophrenia and some methodological aspects are discussed.
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PMID:Immunoglobulin G antibodies to herpes simplex type 1 virus detected by radioimmunoassay in serum and cerebrospinal fluid of patients with schizophrenia. 43 49

The authors measured copper levels in the cerebrospinal fluid of 8 schizophrenic subjects and 6 controls. The schizophrenic subjects had significantly lower CSF copper values than the controls, which is consistent with the hypothesis that there is reduced central activity of copper-dependent enzymes in schizophrenia. These enzymes, tyrosine hydroxylase and dopamine-beta-hydroxylase, are involved in the synthesis and catabolism of dopamine.
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PMID:CSF copper in schizophrenia. 45 56

Measurements of beta-endorphin-like immunoreactivity have been performed in CSF and plasma of patients with schizophrenia and other neuropsychiatric disorders. The detection limit of the RIA was between 20--50 pg/ml (6--15 fmole/ml). In CSF the quantity of beta-endorphin-like immunoreactivity ranges up to 65 pg/ml. The data from schizophrenics and other neuropsychiatric patients show no obvious deviation from the results in a control group of medical patients with normal CSF findings. In plasma the immunoreactive beta-endorphin-like material ranges up to 250 pg/ml. There is only a small tendency to higher values in schizophrenic patients, if compared with different types of neuroses and affective and organic psychoses. In a second series of experiments also this tendency could not be reproduced. In 9 electroconvulsive treatments an increase of blood beta-endorphin-like immunoreactivity was observed 7 times. A possible endorphinergic mechanism in the mode of action of electroconvulsion is hypothesized.
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PMID:beta-Endorphin-like immunoreactivity in cerebrospinal fluid and plasma of patients with schizophrenia and other neuropsychiatric disorders. 48 50

The serum and CSF of 66 patients with functional psychoses were tested for immunoglobulins and antibodies to measles, HSV-I, CMV, and rubella viruses. Ten surgical and 80 neurological patients were controls. There were no significant findings in the serum, consistent with most previous studied. In the CSF 6 of 17 multiple admission schizophrenic patients had definite elevations of IgG or measles antibody and differed significantly from the surgical controls. Immunologically this group resembled the seriously ill neurological patients. No previous study has been made of immunoglobulins or viral antibodies in the CSF of psychiatric patients. It is concluded that further work is warranted in a search for biological subgroups of schizophrenia.
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PMID:Immunoglobulins and viral antibodies in psychiatric patients. 63 87

The authors have observed the evolution of a late catatonic syndrome in a 50 years old woman, without psychological background. They have observed a progressive mental (intellectual) deterioration which have had for a long time a partial and paradoxical aspect, while on the thymic and affective stade an atypical melancolic picture evolved toward a schizophrenic syndrome with catatonic traits which finally came to a stade of marasmus and death after three and a half years of illness. A psychological examination performed at mid course confirmed the mental deterioration without intellectual disorganisation (Wechler) while the Rorschach indicated schizophrenia. The neuro-radiological explorations, repeated several times, have demonstrated the existence of a diffuse cerebral atrophy on the white substance and yet more on the cortex, and it was possible to follow the aggravation of this atrophy. Repeated biological tests were less informative: albumine in the CSF was 0.15 to 0.63 g % and an isolated increase of alpha1-globulines in the CSF was observed at the electrophoresis 4 months before the exitus. Histological examination of cortical biopsies and of the white substance indicates a degenerative encephalopathy with spongiosis and cortical atrophy. Because of the limited value of the histopathological examination, one cannot suggest a systematic interpretation of the catatonic symptoms.
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PMID:[Late catatonic syndrom symptomatic of a degenerative encephalopathy (author's transl)]. 93 Jun 22

The relationships between CSF monoamine metabolites (HVA and 5HIAA), nurses' ratings of clinical symptoms, and telemetered measures of motor movement of ten schizophrenic and ten depressed patients were investigated. There was a significant negative correlation between CSF 5HIAA and both agitation ratings and motor movement in the schizophrenics. CSF HVA correlated positively to anxiety and anger in the depressives. The schizophrenics had a significantly higher CSF HVA than the depressives which appeared unrelated to motor movement. The effects of serotonin turnover and arousal in schizophrenia and the association between CSF metabolite gradients, stress, motor movement, and biogenic amine levels in depression are discussed.
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PMID:CSF amine metabolites, clinical symptoms, and body movement in psychiatric patients. 96 33


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