Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Singular and repeated EEG studies performed in children and adolescents with shift-like schizophrenia permitted to depict some special traits in the bioelectrical brain activity. In all age groups there was a definite tendency to a decrease in the amplitude of fluctuations and to a drop in the "area" occupied by the fluctuations of biopotentials in relation to normal age indices. There was also a relatively high per cent of rapid EEG activity, irregular reactive changes of the biopotentials and paraparoxysmal activity. The changes of corticat rhythmics were to a greater degree influenced by the features of the psychotic attacks rather than by their number and duration of the disease.
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PMID:[Features and dynamics of changes in the bioelectrical activity of the brain in children and adolescents ill with shift-like schizophrenia]. 121 Sep 29

It is still not clear whether brain hemodynamics plays a role in the functional and structural alterations in schizophrenia, since prior imaging studies showed conflicting findings. In this study we non-invasively explored cerebral and cerebellar lobe perfusion in the largest population of participants with schizophrenia thus far studied with perfusion-weighted imaging (PWI). Forty-seven participants affected by schizophrenia and 29 normal controls were recruited. PWI images were acquired following the intravenous injection of a paramagnetic contrast agent. Regional cerebral blood volume (CBV), blood flow (rCBF), and mean transit time (MTT) were obtained with the block-Circulant Singular Value Decomposition (cSVD) for frontal, temporal, parietal, occipital, and cerebellar lobes, bilaterally. Perfusion parameters were separately obtained for both gray and white matter in each lobe. Subjects with schizophrenia showed no significant differences in perfusion parameters when compared with controls. Interestingly, inverse correlations between age at onset and occipital, frontal and cerebellar MTT and between length of illness and frontal CBV were found. Preserved cerebral and cerebellar perfusion in our chronic population may in part be due to the effects of antipsychotic treatment which may have normalized blood volume and flow. Hypoperfusion in relation to chronicity, particularly in the frontal lobe, has been observed in accordance with earlier studies using positron emission tomography.
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PMID:Cerebellar and lobar blood flow in schizophrenia: a perfusion weighted imaging study. 2160 Jul 40