Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Patients suffering from acute schizophrenia are subjected to treatment according to different therapy standards, depending on the individual hospital. Hence, the present study aimed at a comparative investigation of the effects and side effects of fluphenazine dihydrochloride administered to 51 acutely diseased schizophrenics via the intravenous, intramuscular and oral routes. It was also interesting to record the assessment of efficacy, painfulness and, as the case may be, repeated selection of the form of application concerned, by the patients themselves. Finally, we also investigated the relations between the age of the patients, duration of previous hospitalisation, and the effects achieved with the three application forms. Documentation was effected via the following examination instruments described and recommended by the National Institute of Mental Health (NIMH), USA; CGI, BPRS, Dotes, APDI and PTR.
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PMID:[Comparative investigation of action and side effects in intravenous, intramuscular and oral application of fluphenazine dihydrochloride (author's transl)]. 50 43

According to the psycho-pharmacological characteristics, indications, counterindications and side-effects of fluophenazine dihydrochloride, the authors present the results of a simple-blind study of Lyorodin--Jenapharm in a series of 30 in-patients of both sexes, aged between 30 and 65 years. Nosologically, there were cases of schizophrenia and post-process states, delirious hallucinatory syndromes of involution and asthenodithymic syndromes. The drug under the form of pills of 1 and 4 mg was given at average doses of 2-4 mg up to 6-10 mg for 28 days under clinical surveillance and laboratory tests. The estimation of the clinical results revealed the improvement of the symptoms in all investigated cases, a favourable evolution, low incidence and intensity of its side-effects, good tolerance and clinical efficacy comparable to that of Lyogen.
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PMID:[Clinical observations on treatment with flufenazin dihydrochloride (Lyorodin--Jenapharm)]. 263 70

Developed the present study in conjunction with a project that evaluated the psychiatric diagnosis of schizophrenia (Landmark, 1982; Landmark & Leslie, 1982). This design, which included 13 different interview systems for diagnosing schizophrenic disorders, allowed for an in-depth analysis of the Whitaker Index of Schizophrenic Thinking (WIST). Eighty-five outpatients who were receiving long-term chemotherapy for schizophrenia at the Moditen Clinic of London Psychiatric Hospital were reassessed individually using each of the 13 systems, following a clinical interview format, and the WIST. Major statistical analysis evaluated the concurrent validity and discriminatory efficiency of the WIST in comparison to the 13 systems. The WIST was found to show a consistently high agreement with each of the 13 systems for an average WIST discriminatory efficiency of 70%. The WIST is suggested as a practical, easily administered, diagnostic tool that performs well in comparison to the interview systems.
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PMID:The Whitaker Index of Schizophrenic Thinking (WIST) and thirteen systems for diagnosing schizophrenia. 674 68