Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The current emphasis of biological research on schizophrenia has overlooked the importance of the environment in understanding fluctuations in symptoms of this devastating mental illness. One way of reconnecting the individual with his or her environment is by better understanding the subjective experience of the illness and what environmental factors lead to changes in the symptoms of schizophrenia. This study examines the nature of the subjective experience of schizophrenia during two symptom fluctuation episodes, what individuals perceived as the most important symptom fluctuations they experienced during those episodes, and what individuals perceived as causing the fluctuations in symptoms. During both episodes individuals reported primarily mood/affect and physical symptom changes and identified interpersonal interactions as the primary cause of the symptom changes. Mental health professionals should be more aware of and better assess the role of interpersonal interaction as it relates to changes and decompensation in people with schizophrenia.
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PMID:People matter: client-reported interpersonal interaction and its impact on symptoms of schizophrenia. 973 32

Clozapine has the potential to cause agranulocytosis and an association to an increased risk of infections has been suggested. Patients with an ICD-10 F20.x were identified from the Danish Central Psychiatric Research Registry and were linked to the national prescription database to identify schizophrenia patients treated with clozapine from 1996 to 2005(N=3374). Binomial regression and Cox proportional hazards models were used. An increased use of antibiotics was found RR=1.43, CI: 1.26-1.61, P<0.0001 and HR 1.14, 95% CI: 1.05-1.24, P=0.0025 with binomial regression and Cox proportional hazard model, respectively. The exact mechanism for the increased risk remains unknown, but the increased risk might be due to aspiration pneumonia caused by hypersalivation and the sedating properties of clozapine. The findings reported here should alert clinicians to be mindful of infectious processes as yet another possible somatic manifestation of clozapine treatment.
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PMID:Increased use of antibiotics in patients treated with clozapine. 1935 9