Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Results from two studies on HLA antigens in schizophrenic patients were pooled and analyzed. A statistically significant difference appeared in the frequency for HLA-B27, which was increased in the patient group (n = 164) as compared to the controls (n = 585). The strong correlation between this antigen and some forms of arthropathies and the fact that arthropathies and schizophrenia very seldom occur in the same individual suggest that HLA-B27 could serve as a genetic marker for both diseases. The development of either one or the other may depend upon the interplay between the genetic marker (HLA-B27) and other biological and environmental factors. In addition to the potential value of HLA-B27 as a marker for vulnerability to schizophrenia, the human leucocyte antigens may also serve to differentiate between various subtypes of the illness.
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PMID:HLA antigens and schizophrenia: a pool of two studies. 694 7

Various diseases with a noticeable autoimmune component and frequent occurrence within one family show a statistically significant correlation with specific human leucocyte antigens (HLA). This correlation was also found in studies of HLA in psychiatric disorders. However, results have been contradictory. The phenotype frequencies of HLA specificities were investigated in 100 schizophrenic patients and 472 controls from the same geographic area in Germany. The frequency of HLA-B27 was significantly increased in the patient group as a whole and in the subgroups of paranoid patients, chronic schizophrenics, patients with poor prognosis and in patients with the onset of the disease before the age of 20 years. In the latter three subgroups an elevated incidence of HLA-A9 was also found. The combination A9-B27 was detected in 0,63% of our control group and in 7% of the patients. Of these patients 85,7% were chronic paranoid patients with poor prognostic features. The present study indicates a possible marker of genetic heterogeneity in schizophrenia and gives support to the possibility of using HLA typing in genetic studies of schizophrenia as well as in the differential diagnosis and prognosis. Moreover, in spite of the statistical significance of our findings, the fact that the associations are well below 100% indicates that other factors (presumably environmental) must be involved in the etiology of the disease.
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PMID:[The histocompatibility system in schizophrenia]. 698 26