Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Our study examined the relationship between the Minnesota Multiphasic Personality Inventory (MMPI) and the Scale for the Assessment of Positive Symptoms (SAPS; Andreason, 1984) and the Scale for the Assessment of Negative Symptoms (SANS; Andreason, 1983) in patients who met the Diagnostic and Statistical Manual of Mental Disorders (3rd ed., rev.; American Psychiatric Association, 1987) diagnostic criteria for schizophrenia (n = 125). A significant correlation was found between the SAPS Delusions scale and Scale 6 (Paranoia), the SAPS Positive Thought Disorder Scale and Scale F (Infrequency), and the SAPS Positive Thought Disorder and Scale 9 (Hypomania). Additional analysis also shows, however, that severity of symptoms was the best predictor of MMPI scores. Consistent with previous studies, the MMPI appears useful for screening but not for the detailed evaluation of symptomatology of schizophrenic patients.
 ...
PMID:Correlations between the MMPI and the Scale for the Assessment of Positive Symptoms and the Scale for the Assessment of Negative Symptoms in schizophrenic patients. 796 72

Two cases of basal ganglia calcification involving the globus pallidus are presented. Both patients had cognitive dysfunction, temporal lobe-like symptoms (including amnestic state, perceptual distortions, or complex visual hallucinations), and myoclonus. Patient 1 manifested depression, auditory hallucinations, anxiety, paranoia, and postural tremor; patient 2 manifested multifocal dystonia with dystonic tremor. These cases supplement other reports of psychotic features and dementia associated with pallidal pathology. Additionally, the phenomena encountered in these cases are considered in light of recent advances in our understanding of basal ganglia functional pathways. These cases afford a potential pathophysiological window to the possible role of the globus pallidus in these neuropsychiatric conditions. In concert with other recent findings, these cases suggest specific pathway involvement in hallucinations, paranoia, depression, myoclonus, and dystonia. Further research will indicate if these pathways play a role in schizophrenia, mood disorders, and anxiety disorders.
 ...
PMID:Neuropsychiatric disorders, myoclonus, and dystonia in calcification of basal ganglia pathways. 801 2

The diagnostic allocation and aetiological basis of paranoid psychoses with late onset is controversial. We examined the clinical features of patients with a diagnosis of paranoid psychosis and we compared their cranial computed tomography (CT) scans and electroencephalographic (EEG) recordings with findings from matched samples of patients with Alzheimer's disease and non-demented elderly controls. During a 5-year period, 81 patients (15 men and 66 women) with a diagnosis of paranoid psychosis and onset after age 50 were referred to our Institute. They represent 5.4% of the patients older than 50 admitted during the same period. More than half of these patients had first-rank symptoms. The ventricles, anterior and sylvian fissures of the paranoid group were larger than in non-demented controls but smaller than in Alzheimer's disease. The posterior dominant alpha EEG rhythm was slower than in normal aging and faster than in Alzheimer's dementia. If paranoid patients with first-rank symptoms were distinguished from the ones without, the former had less severe brain atrophy and faster posterior dominant rhythm, although they received higher doses of neuroleptics. This could be explained by the existence of at least 2 subgroups of late paranoid psychosis: late-onset schizophrenia and organic paranoid syndrome, the former characterized by first-rank symptoms and less severe brain atrophy, the latter by more severe EEG and CT scan changes with a closer resemblance to degenerative brain disease.
 ...
PMID:Organic factors and the clinical features of late paranoid psychosis: a comparison with Alzheimer's disease and normal ageing. 806 72

In a geographically defined area sample of 141 long-term psychiatric patients in day care in south London, the relationship between tardive dyskinesia (TD) and other aspects of illness, treatment, and social and psychological functioning were studied. The results are compared with previous findings. TD was significantly associated with parkinsonian symptoms and with the number of years in contact with the psychiatric services. There was a trend, in affective disorder only, towards an association with current neuroleptic dose. The patients with affective disorder also had higher rates of TD than patients with schizophrenia and paranoid psychosis. History of treatment with ECT correlated negatively with TD among those with schizophrenia, and positively among those with affective disorder. As in other studies, duration of neuroleptic treatment did not correlate with the presence or absence of TD. In contrast to some previous reports, age and cognitive status were not related to TD status. Possible reasons for this are discussed.
 ...
PMID:New findings on tardive dyskinesia in a community sample. 810 84

The revealed variants dissimulation in 120 mental patients at initial stage of schizophrenia stimulated evaluation of premorbid personality changes and their significance in the formation of dissimulative tendencies. 63 patients showed reticence, 49--affective instability, 8--increased irritability and unmotivated mood changes. Comparative analysis of clinical variants of dissimulation with the aspects of personality permit to suggest their importance in formation of behaviour motives in the development of the schizophrenia process at the paranoia stage.
 ...
PMID:[The personality-modulated dissimulative behavior of patients with paranoid schizophrenia]. 820 59

Among a sample of 40 severe migraine sufferers, males and females displayed common personality profiles. Both sexes exhibit heightened scores on those MMPI clinical scales associated with neuroticism (hypochondriasis, depression and hysteria). Female migraine sufferers were further characterised by elevated scores on the primary scales constituting the psychotic tetrad (paranoia, psychaesthenia, schizophrenia, and hypomania). Migraine females appeared to differ from male patients with respect to a dimension associated with sex-role conformity (loaded on the L-scale and masculinity-femininity). The implication of these results are considered.
 ...
PMID:MMPI profiles of male and female migraine sufferers. 821 5

We compared 20 patients with late-onset schizophrenia, 7 with delusional disorder with hallucinations (paraphrenia), and 13 with delusional disorder without hallucinations (late-onset paranoia). We found that these three categories could be distinguished from each other on some clinical parameters. Late-onset schizophrenia was characterized by bizarre delusions; auditory hallucinations; to a lesser degree, first-rank and negative symptoms; and premorbid personality of the paranoid or schizoid type. Paraphrenia was associated with predominantly nonbizarre delusions, auditory hallucinations, earlier onset of symptoms, and paranoid or schizoid personality. Paranoia (late-onset) was characterized by late onset of symptoms, nonbizarre delusions, relatively intact premorbid personality, and an underlying physical stratum.
 ...
PMID:Clinical characteristics of late-onset schizophrenia and delusional disorder. 830 21

The South Oaks Gambling Inventory was administered to 136 consecutively admitted inmates in a medium-security prison in Nevada. According to the criteria of the authors of this instrument, 22.79% of these inmates had some problem and 26% were probable pathological gamblers. Significant positive correlations with the F, depression, psychopathic deviate, psychasthenia, paranoia, schizophrenia, and Mac Andrew alcoholism scales of the Minnesota Multiphasic Personality Inventory (MMPI) were found. Gambling score was negatively correlated with the Raven's Standard Progressive Matrices measure of intelligence. Clinical implications are suggested.
 ...
PMID:Correlates of pathological gambling propensity in prison inmates. 830 46

The psychic ill man, no matter the gravity of the syndrome presented, is not undesirable and does not constitute a contraindication in ocular surgery. But in these situations a correct evaluation of the general and ocular state must be done, and also a correct premedication, a local or general on case good-conducted anesthesia and a close cooperation with the psychiatrist. Are discussed the problems of the little psychiatry which appear in the ocular interventions: senile psychosis, unorganical psychoses like ambulatory schizophrenia, maniacal-depress psychosis and paranoia decompensated by surgical act.
 ...
PMID:[Psychiatric aspects in eye surgery]. 833 30

In this survey, 274 patients were sent a questionnaire concerning satisfaction with psychiatric treatment and the ward 1 month after their discharge from hospital. Fifty-two percent of the patients responded. Answers to the 56 items of patient satisfaction were analyzed in relation to patient diagnoses and treatment given. Patients who were diagnosed as suffering from affective disorders or from reactive psychoses were more satisfied than patients with schizophrenia or paranoia or with transitory adjustment reactions. Patients who had no personality disorder diagnosis and patients with character neurosis were more satisfied than patients with antisocial or borderline personality disorders. Patients on antidepressant medication were much more satisfied than other patients. The results of the study are discussed with regard to the need of further research in this area and to quality assurance.
 ...
PMID:Satisfaction with care reported by psychiatric inpatients. Relationship to diagnosis and medical treatment. 835 87


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>