Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Forty-four selected patients with "hard core" functional psychiatric illness were treated by bimedial prefrontal leukotomy, in which only the medial half of the prefrontal white matter of both frontal lobes was divided. This operation differs from the conventional or "standard" leukotomy which divides the entire prefrontal white matter. There were six patients with personality disorders, 25 psychoneurotics, 12 schizophrenics, and one with involutional melancholia. Forty-two of the 44 patients had thorough psychiatric follow-up, ranging from one to seven years postoperatively. They were assessed clinically and also on a point-rating scale of assessment.Seventy-six per cent of these patients had excellent or satisfactory outcomes. The most striking benefit was decrease in anxiety and tension.Modified leukotomy is a safe and effective method of reducing the symptoms of excessive tension, anxiety, fear or depression in patients with a variety of illnesses, including anxiety neurosis, phobic psychoneurosis, obsessional neurosis, neurotic or psychotic depressive reactions and schizophrenia. The operation should be considered in such neurotic, personality and psychotic illnesses when medical treatment has failed.
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PMID:A new look at bimedial prefrontal leukotomy. 541 Apr 13

Adolescents aged 12-15 years, randomly selected from a psychiatric outpatient clinic, psychiatric consultation service, and general pediatric outpatient clinic, were given a complete psychiatric evaluation and structured diagnostic interview. Of 121 subjects studied, 100 satisfied Rutter and associates' criteria for a childhood psychiatric disorder. When these subjects were rediagnosed according to Feighner and associates' research diagnostic criteria (similar to DSM-III criteria), 52 fulfilled the criteria for an adult disorder. Diagnoses included antisocial personality, hysteria, schizophrenia, depression, mental retardation, anxiety neurosis, and undiagnosed psychiatric illness. There was a correlation between diagnosis according to Rutter and associates' criteria and adult diagnosis.
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PMID:Adult psychiatric disorders in psychiatrically ill young adolescents. 665 Jun 88

Fifteen epidemiological studies on psychiatric morbidity in India have been analysed. National all-India prevalence rates for 'all mental disorders' and five specific disorders have been worked out The national prevalence rates for 'all mental disorders' arrived at are 70.5 (rural), 73 (urban) and 73 (rural + urban) per 1000 population. Prevalence of schizophrenia is 2.5/1000 and this seems to be the only disorder whose prevalence is consistent across cultures and over time. Rates for depression, anxiety neurosis, hysteria and mental retardation are provided. Urban morbidity in India is 3.5 percent higher than the rural rate, but rural-urban differences are not consistent for different disease categories. In Hindi speaking north India, mental morbidity amongst factory workers is two and half times that of the non-industrial urban inhabitants and five times the rural morbidity. The present data are expected to serve as baseline rates for mental health planners and for psychiatrists interested in epidemiological studies.
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PMID:Epidemiological findings on prevalence of mental disorders in India. 2140 3


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