Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Biological tests may help clarify the relationship of schizoaffective disorder to major depressive disorder (MDD) and schizophrenia (SCZ). Thyrotropin-releasing hormone (TRH), 500 micrograms, was administered intravenously to eight schizoaffective depressed (SD), ten SCZ, 23 MDD patients and 43 healthy controls (HC), all males, ages 20-66 years and drug-free. Research Diagnostic Criteria (RDC) were utilized for establishing diagnoses, Hamilton Rating Scale for Depression (HRSD) total scores were used for assessing depressive symptoms. There were no differences in dmax PRL (post-TRH prolactin peak minus baseline, mean +/- SD) amongst SD, SCZ and HC groups (27.3 +/- 5.2, 28.8 +/- 5.4 and 31.5 +/- 5.6 ng/ml respectively). Mean dmax PRL in MDD was significantly lower than each of the other three groups (17.1 +/- 2.2 ng/ml, P less than 0.05 for all). The essentially normal PRL response to TRH in SD, significantly different from MDD but similar to SCZ parallels our previous observations on the pattern of thyrotropin (TSH) response to TRH in the same diagnostic groups. These biological findings may be taken to indicate that schizoaffective disorder, depressed subtype, is closer to schizophrenia than to major depressive disorder. However, they cannot be considered definitive evidence to that effect since schizoaffective disorders are known to be quite heterogeneous, and since the utilized biological tests lack specificity.
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PMID:Prolactin response to thyrotropin-releasing hormone in schizoaffective depressed compared to depressed and schizophrenic men and healthy controls. 212 54

Melatonin secretion has been suggested as a marker of both circadian and noradrenergic dysfunction in affective disorders. Seventy-two newly admitted psychiatric inpatients [49 with major depressive disorder (MDD), 12 with schizophrenia, and 11 with intermittent depressive disorder (IDD)] underwent neuroendocrine screening at 0200, 0800, 1600 and 2300 hours prior to and the day following dexamethasone administration. All groups showed a drop in cortisol following dexamethasone. Dexamethasone nonsuppression was found in 20 of 49 patients with MDD, in none of the schizophrenics and in none of those with intermittent depressive disorder. Mean melatonin levels decreased significantly after the administration of dexamethasone across all four groups. Overall, the schizophrenic group had a significantly greater mean melatonin level than each of the other three groups, whereas the three depressive groups did not differ significantly from one another. Only at 2300 hours did both the schizophrenic group and the MDD patients with normal dexamethasone suppression show significantly greater melatonin levels than the MDD patients with dexamethasone nonsuppression or the IDD group. The observed trend for a low circadian melatonin profile in IDD patients with superimposed personality disorders is puzzling.
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PMID:Nocturnal melatonin and cortisol secretion in newly admitted psychiatric inpatients. Implications for affective disorders. 214 98

Although several studies reveal that cognitive therapy effectively remediates depressive symptoms in many unipolar nonpsychotic depressed outpatients, the question as to which depressions respond to cognitive therapy remains unanswered. We hypothesized that patients with reduced rapid eye movement (REM) latency (less than or equal to 65.0 min) before treatment would be less likely than those with nonreduced REM latency (greater than 65.0 min) to respond to cognitive therapy. The rationale for this prediction was that endogenous depressions are more likely to exhibit this abnormality and also tend to respond to tricyclic antidepressant medication. Thus, we queried whether these depressions might also respond less to a psychosocial intervention. To date, 39 outpatients with nonpsychotic, unipolar major depression (by the Schedule for Affective Disorders and Schizophrenia-Lifetime Version and Research Diagnostic Criteria) who score at least 14 on the 17-item Hamilton Rating Scale for Depression have completed this project, which is still in process. Preliminary findings do not suggest a systematic relationship between pretreatment REM latency and response to cognitive therapy. Further, these results suggest that at least some patients with biological dysregulation, as indicated by reduced REM latency, show a favorable response to an acute trial of cognitive therapy. Study limitations include a small sample of patients who exhibit extremely reduced REM latencies (less than or equal to 51.0 min) and a small number of endogenous depressions. Data collection continues.
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PMID:Does the pretreatment polysomnogram predict response to cognitive therapy in depressed outpatients? A preliminary report. 224 3

Performance in temporal discrimination of time intervals in the range of milliseconds was compared in 80 healthy subjects, 27 patients with schizophrenic disorders, 33 patients with major depression, 21 patients with dysthymic disorders. For schizophrenic patients as well as for patients with major depression, pronounced deficits in duration discrimination could be demonstrated as compared to the healthy control group (p less than .01). Patients with dysthymic disorders and schizophrenic patients differed significantly from the melancholic group (p less than .01 and p less than .05, respectively). The results are discussed on the basis of the assumption of an internal clock, implying that the clock rate is highest and therefore temporal resolution is best with healthy subjects. With psychiatric patients performance in temporal discrimination was impaired to a slowing down in clock rate and thus decreased temporal resolution. There is strong evidence that changes in clock rate depend on the effective level of dopamine. This leads to the conclusion that temporal discrimination thresholds may be seen as an indicator for deviations from the optimal level of dopaminergic activity in psychiatric patients. In addition, possible effects due to age and medication are discussed.
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PMID:Temporal discrimination in schizophrenic and affective disorders: evidence for a dopamine-dependent internal clock. 226 30

Expressed emotion (EE) refers to a set of emotional aspects of speech for which ratings have been derived. Seven independent studies have established that higher EE ratings in the relatives of patients with schizophrenia predict higher rates of relapse in these patients and two studies have established an association of higher EE in spouses with relapse of depression in their mate. There are no previous studies of parental EE as a predictor of childhood affective disorder or other disorders not in the schizophrenia spectrum. In this study we investigated the relationship between the level of maternal EE and the incidence of DSM-III affective disorder (major depression or mania or dysthymia), substance abuse, or conduct disorder in 273 children. We found that a higher degree of maternal expressed emotion was associated with a three-fold increase in a child's risk (odds multiplier) for having at least one of the following diagnoses: depressive disorder (major depression or dysthymia), substance abuse, or conduct disorder. This increased risk acts in addition to the increased risk of child diagnosis associated with parental affective illness. Research and clinical implications are discussed.
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PMID:Maternal expressed emotion and parental affective disorder: risk for childhood depressive disorder, substance abuse, or conduct disorder. 226 12

Admissions to a mother-baby unit in a psychiatric hospital were reviewed over a 51 month period. Forty-four mothers (3 admitted twice) and 44 babies were admitted. Eighteen women were diagnosed as having major depression (1 admitted twice), 14 with schizophreniform psychosis, 8 with schizophrenia (2 admitted twice), 4 with bipolar disorder, 2 with anxiety disorders and in 1 diagnosis was deferred. Data are presented from these women's background and that related to pregnancy, as well as duration of stay and treatment in the unit. A description of the unit is also included.
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PMID:Review of a mother-baby unit in a psychiatric hospital. 233 79

Ventricle-brain ratio was measured by CT scan in 24 bipolar patients, 27 unipolar patients with major depression, 108 schizophrenic patients, and 75 normal control subjects. The male bipolar patients had significantly larger ventricles, but the depressive patients did not. The findings suggest the possibility that ventricular enlargement in bipolar patients is independent of age, as it appears to be in schizophrenia, whereas in depressed patients it may be related to the aging process. Ventricular enlargement in bipolar patients was not related to relevant clinical correlates, such as response to treatment, history of substance abuse, history of ECT, or cognitive impairment.
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PMID:Ventricular abnormalities in affective disorder: clinical and demographic correlates. 235 74

Prognosis is an important issue among patients who have psychotic features and a depressive syndrome; some have outcomes that suggest diagnostic revisions to schizophrenia, and this has far-reaching implications for treatment. To explore this issue, we used biannual evaluations to follow up 103 such individuals for 5 years. Patients with Research Diagnostic Criteria schizoaffective disorder experienced substantially more morbidity of various sorts than did patients with Research Diagnostic Criteria psychotic major depression. Within the group with schizoaffective disorder, patients with the chronic subtype experienced more morbidity than did those with nonchronic schizoaffective disorder; the mainly affective--mainly schizophrenic distinction had less prognostic significance. Factors that predicted sustained delusions at the end of follow-up were exclusively historical and suggested a poor-outcome prototype patient who is single, was socially impaired as an adolescent, and has a history of schizophrenialike psychotic features temporarily dissociated from affective symptoms.
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PMID:Affective syndromes, psychotic features, and prognosis. I. Depression. 236 Aug 58

Forty patients with migraine who were attending a specialist clinic were interviewed with the Schedule for Affective Disorders and Schizophrenia--Lifetime version. Sixteen (40%) had a history of major depression which was of endogenous type in 15, according to Research Diagnostic Criteria. The tyramine test, a previously established trait marker for endogenous depression, showed that the migraine group as a whole had significantly low values compared with 14 normal controls, due almost entirely to low values in the endogenous depressive subgroup; there were no differences between diet-sensitive and non-diet-sensitive migraine patients. Thus depression in patients with migraine seems unlikely to be secondary to migraine per se. A substantial subgroup of patients with migraine may possess an inherent predisposition to endogenous depression.
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PMID:High incidence of endogenous depression in migraine: confirmation by tyramine test. 239 20

Psychiatric inpatients who commit suicide differ characteristically from other inpatients. Nearly 60% of them are between 30 and 60 years old and belong to the age group of those who are usually employed. Diagnostically most of them suffer from endogenous psychoses like schizophrenia or major depression. The distribution of the duration of illness shows two peaks: one during the first years and a second after many years of illness. A nearly constant percentage of 40% presents a striking life history, including psychiatric disorders in the family, retardation during childhood, interrupted school education and lack of vocational training. Suicidal attempts in the past are predictive for suicidal behaviour and suicide in the future. The rate of suicides (per 100,000 psychiatric inpatients) is increasing, however there is no evidence for a connection with treatment under open or closed conditions. In case of serious suicidal risk it may be necessary to take antisuicidal measures like temporally limited treatment in a closed ward. On the other hand the liberality which has been established in psychiatric hospitals over the last ten years might be reduced, if restrictive measures are taken in any case of suicidal risk.
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PMID:[Suicide in psychiatric clinic patients]. 239 64


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