Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Four cases of self-enucleation are reported. Self-induced ocular mutilation is uncommon. Self-enucleation is rare and is specifically associated with paranoid delusions, either as a result of a drug-related toxic psychosis or in the functional psychoses, especially schizophrenia. An association with solvent abuse is reported. Such patients use self enucleation as a form of parasuicide and may mutilate themselves in other ways. In the management of such patients close co-operation between ophthalmologist and psychiatrist is important, as further self injury, including suicide is common.
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PMID:Self-enucleation and psychosis. 239 50

We report a neuropathological case of the brain of a 22-year-old male solvent abuser. He had also been diagnosed as suffering from schizophrenia. Neurohistology revealed the presence of Rosenthal fibers (RFs) in subpial and perivascular collections in the medulla, the floor of the 3rd and 4th ventricles, and also in the spinal cord. There was mild demyelination in the frontal, temporal, and parietal lobes, as well as the left dorsal column in the spinal cord. There was bilateral basal ganglia calcification. Demyelination and RFs have been the hallmark of the diagnosis of adult Alexander's disease. We urge that these are insufficient criteria for this nosological category, and suggest the alternative and more appropriate label of Rosenthal fiber encephalopathy. In view of the known toxic, clinical effects of chronic solvent abuse, and the lack of knowledge of the neuropathological effects, we also tentatively note the association of the solvent abuse with the neuropathology, but are unable to assert any causal link.
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PMID:Rosenthal fiber encephalopathy presenting with demyelination and Rosenthal fibers in a solvent abuser: adult Alexander's disease? 899 49