Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Etiopathogenetic research gives rise to the suspicion that the classifications on hand pool heterogeneous disturbances under the heading of schizophrenia. This has drawn increasing attention to the necessity of identifying schizophrenic subsyndromes. Investigations using factor analysis revealed convincingly three major groups of schizophrenic symptoms: 1. a "negative factor", 2. a "psychoticism factor", comprising delusions and hallucinations and 3. a "disorganization syndrome" whose cardinal item is formal thought disorder. These studies have not yet furnished final results, but already opened insights enabling the conceptualization of syndrom-oriented therapies. The observation that the psychoticism symptomatology occurs in the frame of a "dynamic instability", based on a thymopsychic hyperreactivity, is in this regard especially important. In schizophrenic patients this hyperreactivity may be caused by secondary biological compensation mechanisms - such as perhaps an "up-regulation" of postsynaptic dopamine receptors. "Classic" neuroleptics can only correct the dynamic instability and thus eliminate psychoticism symptoms and reduce the accentuation of disorganization symptoms. They have, however, no influence upon negative symptomatology and can moreover aggravate "secondary" negative symptoms and especially impede cognitive functions. New "atypical" neuroleptics do not produce these side effects. They seem to have a reducing influence on negative symptoms and to improve cognitive functions. In each neuroleptic therapy a stepwise drug withdrawal should make clear whether or not a continous treatment is necessary. In the first case the needed efficacious dosis must be identified. The patients must learn to recognize relapse prodromes and to prevent the appearance of acute episodes through appropriate modifications of the medication. This strategy requires the combination with adequate psychotherapeutic methods enabling the patient to master persistent negative and disorganization symptoms in the best possible way.
 ...
PMID:[New concepts of schizophrenic sub-syndromes - consequences for treatment]. 1153 59

Several studies have found a significant increase in the prevalence of some personality disorders in the first-degree relatives of patients with schizophrenia; other studies have found subtle neuropsychological deficits in these relatives. However, little is known about the specificity of the personality traits reported or about the relationship between these traits and the neuropsychological deficits.One-hundred first-degree relatives of patients with schizophrenia (SR) and 88 first-degree relatives of affective psychotic patients (APR) completed the Eysenck Personality Questionnaire which measures extraversion, neuroticism, and psychoticism; they were also administered the National Adult Reading Test (NART), the Trail Making Test (TMT) and a Verbal Fluency Test (VFT). The male relatives of patients with schizophrenia scored significantly higher on the psychoticism scale than the male relatives of affective psychotic patients. In the SR group, there were significant correlations between the TMT performance and the extraversion scores and, between the IQ scores and the psychoticism scores. However, when logistical regression analyses were performed, none of the three personality scores predicted any of the neuropsychological performance in either the SR or the APR group. These results indicate some specificity as well as sex differences in the psychoticism dimension. Moreover, the relationship between the personality dimensions and the neuropsychological performance could indicate that psychoticism increases vulnerability to psychosis whereas extraversion decreases it.
 ...
PMID:Personality dimensions and neuropsychological performance in first-degree relatives of patients with schizophrenia and affective psychosis. 1204 47

The 18-item Manic-Depressiveness Scale was revised via a Rasch top-down purification' procedure to provide a new 12-item scale with no significant age or sex bias. Application of this scale to previously collected data indicated that patients with manic-depression and schizophrenia receive comparable scores, which are significantly higher than those of a control group of students. Moreover, for a subgroup of patients with manic-depression, scores correlated .55 (p<.001) with number of manic-depression-relevant medications being taken. These findings lend support to the validity of the Rasch Manic-Depressiveness Scale as a general measure of psychoticism and psychiatric status.
 ...
PMID:Preliminary validity data on the Rasch Manic-Depressiveness Scale. 1209 May 12

The binocular depth inversion illusion (BDII) has been shown to be a sensitive measure of impaired visual information processing under conditions including cannabinoid-intoxicated states, alcohol withdrawal, sleep deprivation, and in patients with positive symptoms of schizophrenia. This study assessed whether the BDII could detect subtle cognitive impairment due to regular cannabis use by comparing 10 regular cannabis users and 10 healthy controls from the same community sources, matched for age, sex, and premorbid IQ. Subjects were also compared on measures of executive functioning, memory, and personality. Regular cannabis users were found to have significantly higher BDII scores for inverted images. This was not due to a problem in the primary processing of visual information, as there was no significant difference between the groups for depth perception of normal images. There was no relationship between BDII scores for inverted images and time since last dose, suggesting that the measured impairment of BDII more closely reflected chronic than acute effects of regular cannabis use. There were no significant differences between the groups for other neuropsychological measures of memory or executive function. A positive relationship was found between EPQ-R-psychoticism and cannabis, tobacco, and alcohol use. Cannabis users also used significantly larger amounts of alcohol. However, no relationship was found between BDII scores and drug use other than cannabis or psychoticism. Compared to the other neuropsychological tests used, the BDII appears to be a more sensitive tool for the detection of subtle impairments in visual information processing related to chronic cannabis use.
 ...
PMID:Reduced binocular depth inversion in regular cannabis users. 1295 20

Several studies have found a significant increase in the prevalence of some personality disorders in the first-degree relatives of patients with schizophrenia; other studies have found subtle neuropsychological deficits in these relatives. However, little is known about the specificity of the personality traits reported or about the relationship between these traits and the neuropsychological deficits. One hundred first-degree relatives of patients with schizophrenia (AS) and 88 first-degree relatives of affective psychotic (APA) patients completed the Eysenck Personality Questionnaire which measures extraversion, neuroticism, psychoticism. They were also administered the National Adult Reading Test (NART), the Trail Making Test (TMT) and a Verbal Fluency Test (VFT). In the AS group, the male relatives scored significantly higher on the psychoticism scale than the male relatives in the APA group. There were no significant differences in personality between female relatives of the 2 patients groups. In the AS group, the NART scores were superior when the psychoticism scores were lower and the TMT performance was better when the extraversion scores were higher. These results seem to indicate some specificity as well as sex differences of the psychoticism dimension. Moreover, the relationship between the personality dimensions and the neuropsychological performance could indicate that psychoticism increases vulnerability to schizophrenia whereas extraversion decreases it.
 ...
PMID:[Personality dimensions and neuropsychological performance in first-degree relatives of patients with schizophrenia and by affective psychosis]. 1502 87

We investigated the relationships of anti- and prosaccades with psychometric schizotypy. One aim was to estimate the role of negative emotionality and general psychopathology (i.e. neuroticism) in this relationship. 115 non-clinical volunteers underwent infrared oculographic assessment of antisaccades and prosaccades. Schizotypy was assessed with the Personality Syndrome Questionnaire (PSQ-80), the Rust Inventory of Schizotypal Cognitions (RISC), and Eysenck Personality Questionnaire-Revised (EPQ-R) Psychoticism. Higher positive schizotypy scores predicted increased antisaccade errors (RISC) and greater prosaccade spatial error (PSQ-80 Unreality). Greater thought disorder (PSQ-80 Activity) predicted shorter prosaccade latencies. EPQ-R Neuroticism was substantially correlated with schizotypy but was not related to saccadic measures and did not account for their relationship with schizotypy. We conclude that saccadic performance patterns in schizotypy are not due to negative emotionality or general psychopathology, but specific to schizophrenia spectrum signs and symptoms.
 ...
PMID:Saccadic eye movements, schizotypy, and the role of neuroticism. 1531 95

This study used the Picture Arrangement subtest of the Wechsler Adult Intelligence Scale to assess social cognitive functioning of psychotic patients diagnosed with bipolar, schizophrenia, or schizoaffective disorder. All participants were rated on positive and negative symptom rating scales, from which three symptom dimensions were obtained. Symptom dimensions were not significantly related to ratings of symptom severity or mental status examination scores. Disorganized symptoms were correlated with a wide range of impairments on nearly all subscale measures of social cognition. Negative symptoms were correlated with lower ratings of capacity for emotional investment, complexity of representations, and integration of episodes. Psychoticism was associated with negative affect tone. Diagnostic categories were not related to social cognitive impairments independent of estimates of premorbid level of cognitive function. Evidence of syndromal differences suggests that heterogeneity of variance in studies of functioning of schizophrenic patients can be reduced by inclusion of symptom dimensions.
 ...
PMID:Social cognition and symptom dimensions. 1626 Sep 32

This investigation aimed to determine whether impaired insight influences the validity of self-report test scores in schizophrenia and schizoaffective disorder. 274 outpatients enrolled in work rehabilitation completed the Beck Depression Inventory (BDI), Eysenck Personality Questionnaire (EPQ), Bell Object Relations and Reality Testing Inventory (BORRTI), and NEO-Five Factor Inventory (NEO-FFI). Self-report scores were compared to clinician's ratings on comparable personality and symptom dimensions on the Positive and Negative Syndrome Scale (PANSS), the Work Behavior Inventory (WBI), and the Quality of Life Scale (QLS). The influence of insight was determined using the Scale for Unawareness of Mental Disorder (SUMD). In the first analysis, clinician SUMD ratings of patient insight were associated with self-report accuracy. In a second analysis, patients were categorized into good and poor insight groups based on SUMD ratings and compared on self-report and clinician report variables. Results suggest that poor insight patients accurately report less Neuroticism and Agreeableness, and more Psychoticism than good insight patients, but individuals with poor insight wish to present themselves as more extraverted than they actually are, and they are likely to be more certain of their perceptions than they should be. It appears that self-report measures may be valid for most personality and symptom domains.
 ...
PMID:Are self-reports valid for schizophrenia patients with poor insight? Relationship of unawareness of illness to psychological self-report instruments. 1734 20

Although the concept of remission has been widely accepted and utilized in depression and anxiety disorders, there has been much less emphasis on defining remission in schizophrenia. Recently, an expert consensus definition of remission in schizophrenia was proposed along specific operational criteria for the attainment of remission focusing on the three core dimensions of psychopathology identified within schizophrenia: psychoticism, disorganization and negative symptoms. To date, the criteria have been applied retrospectively to several clinical studies, and these have demonstrated that the proposed definition of remission correlates significantly with established measures of symptom severity, functioning and quality of life, and appears achievable for a significant proportion of patients receiving at least 3 months of pharmacotherapy. In this article we extend the notion of remission to include an examination of the possible association of several modifiable and unmodifiable factors and co-morbidities on remission status. We also propose an investigation into the likelihood of different patient populations in achieving remission as well as assessing the impact of remission on health care costs and family burden. Since cognitive dysfunction and negative symptoms may be strongly correlated with a lower likelihood of achieving remission, we recommend retrospective and/or prospective studies to determine the relationship between neurocognitive status and the predominance of negative symptoms at treatment start and the probability of achieving remission. Taken together, these studies should help identify key predictors of remission, further define the remitted state, reduce therapeutic pessimism, raise treatment expectations and chart a strategy for further research in this important area.
 ...
PMID:Remission in schizophrenia: applying recent consensus criteria to refine the concept. 1776 80

Longitudinal validity of Brief Symptom Inventory subscales was examined in a sample (N = 318) with schizophrenia-related illness measured at baseline and every 6 months for 3 years. Nonlinear factor analysis of items was used to test graded response models (GRMs) for subscales in isolation. The models varied in their within-time and between-times parameter constraints, with the homogeneous model being the least constrained, followed by the 2-parameter GRM and 1-parameter GRM. Results show that 4 subscales (Interpersonal Sensitivity, Hostility, Paranoid Ideation, Psychoticism) were consistent with the 1-parameter GRM, and 5 subscales (Somatization, Obsessive-Compulsive, Depression, Anxiety, Phobic Anxiety) were consistent with the 2-parameter GRM. There is evidence that the 9 subscales may be validly used to study change in single constructs over time.
 ...
PMID:Longitudinal construct validity of Brief Symptom Inventory subscales in schizophrenia. 1784 21


<< Previous 1 2 3 4 5 Next >>