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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Schizophrenic patients, whether thought-disordered or not, were found to perform worse than other patients when sorting schematic faces, but not when sorting equivalent abstract material. This information-processing deficit was found to be related to self-rated psychoticism scores as well as to factor scores on the factor of schizophrenia derived from the analysis of psychiatrists' ratings of the patients on a large number of symptoms.
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PMID:Psychoticism and thought disorder in psychiatric patients. 735 31

The use of a structured diagnostic interview (The Schedule for Affective Disorders and Schizophrenia) with 58 consecutively admitted general adult psychiatric patients revealed that 62.1% of them abused alcohol and 58.6% had a substance use disorder. The drug abusers did not differ significantly from the nonabusers on mean psychoticism (Brief Psychiatric Rating Scale) scores. However, they received higher doses of antipsychotic agents (mean daily dose 1022 mg CPZ EQ (SD = 614) vs 609 mg CPZ EQ (SD = 481); z = 2.58, p < .01) to achieve stabilization. The clinical implications of this finding are discussed.
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PMID:Relationship between concurrent substance abuse in psychiatric patients and neuroleptic dosage. 763 11

The authors examined normal personality characteristics of monozygotic (MZ) twins discordant for schizophrenia. Twenty pairs of discordant twins were analyzed; 11 pairs of MZ twins concordant for schizophrenia served as a comparison group. Personality was assessed using the Multidimensional Personality Questionnaire (MPQ; A. Tellegen, 1995). Among discordant twin pairs, twins with schizophrenia were more deviant than normal co-twins on all but 4 of the MPQ's scales. Analysis of MZ twin correlations among the discordant twin pairs revealed substantial erosion of personality similarity as compared to normal individuals, although a cluster of scales related to Constraint/Psychoticism showed significant correlations. The results highlight striking personality divergence related to nonshared environmental influences. It is not possible to determine the point at which the twins diverged, although previous findings from this sample suggest that the observed personality differences may reflect effects of schizophrenia on normal personality.
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PMID:Normal personality characteristics in identical twins discordant for schizophrenia. 767 72

One hundred and twenty women recruited from attenders at the antenatal clinic of the Obstetrics Department of a general hospital were asked to complete ad hoc questionnaires during pregnancy; they were then interviewed by psychiatrists using a structured diagnostic interview, the Schedule for Affective Disorders and Schizophrenia (SADS). Nineteen (16%) women were identified as having an onset of an affective disorder during the period of pregnancy, mainly (68%) during the first trimester. As compared with the women without any such onset (controls), the women with pregnancy-related affective disorder (PRAD) were characterized by (1) it being their first pregnancy or first delivery with past termination of pregnancy, (2) early loss of either parent by death, (3) high Eysenck Personality Questionnaire (EPQ) Neuroticism (N) and Psychoticism (P) scores, (4) living in a flat with either a plan to stay there after the forthcoming childbirth or an expectation that their accommodation would be crowded, and (5) negative response to the news of the pregnancy by the husband with low intimacy. The effects of these factors were additive since the probability of developing a PRAD episode was highly correlated with the number of factors reported.
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PMID:Psychological and social correlates of the onset of affective disorders among pregnant women. 813 20

While structured psychiatric interviews have generally succeeded in identifying higher rates of schizotypal personality disorder in relatives of schizophrenia versus control probands, self-report questionnaires designed to assess schizotypy have been less successful at distinguishing these groups of relatives. In the Roscommon Family Study, an epidemiologically based, case-controlled study conducted in the west of Ireland, relatives were administered a short form of Eysenck's Psychoticism scale and shortened and modified versions of the scales for magical ideation and social anhedonia developed by Chapman and colleagues. We compared, with relatives of matched controls, relatives of four proband groups: schizophrenia, other nonaffective psychoses (ONAP), psychotic affective illness (PAI), and nonpsychotic affective illness (NPAI). Only social anhedonia scores successfully differentiated, at modest levels of significance, relatives of schizophrenia versus control probands. Levels of magical ideation did not distinguish relatives of schizophrenia, ONAP, PAI, or NPAI probands from relatives of controls. Compared to controls, ONAP probands had significantly elevated psychoticism scores, but no such increase was seen in relatives of schizophrenia, PAI, or NPAI probands. Dimensions of schizotypy assessed at personal interview were significantly better at differentiating relatives of schizophrenia and control probands than our measures of social anhedonia, magical ideation, or psychoticism. Although psychiatric interviews in this sample have shown that clinically assessed schizotypal personality disorder and traits strongly aggregate in relatives of schizophrenia patients, of the three self-report instruments designed to assess schizotypy, only one even modestly identifies relatives of schizophrenia versus control probands. These results suggest that, compared with psychiatric interviews, self-report questionnaires are less successful at assessing underlying familial vulnerability to schizophrenia.
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PMID:Self-report measures of schizotypy as indices of familial vulnerability to schizophrenia. 887 1

A replication is reported of a three-factor--active, withdrawn, unreality--structure of schizotypy measured with the Schizotypal Personality Questionnaire (SPQ) in the normal population, a structure which has close affinities with a three-syndrome model of schizophrenia. Cognitive asymmetry patterns and arousal scales are found in the companion report--Part II in this issue of the Schizophrenia Bulletin. Here the withdrawn factor--loneliness and constricted affect--was also complemented by the physical anhedonia scale. The original sample (1995) was then combined with the replication sample to examine associations with the dimensions of extraversion-introversion, neuroticism, and psychoticism. Introversion loaded on the first withdrawn factor. The second unreality factor--unusual perceptions, magical beliefs, and ideas of reference--was unrelated to the Eysenck dimensions. Psychoticism loaded on the third active factor--eccentricity and odd speech. Neuroticism formed a fourth, nonspecific factor with social anxiety and suspiciousness. Insufficiencies in current measures of the structure of schizotypy and schizophrenia are discussed. These include the absence of activity-arousal from the SPQ, the limited assessment of cognitive disorganization in schizotypy, and its heterogeneity in schizophrenia. The history of the active-withdrawn classification and its importance in further elucidation of schizotypy and schizophrenia are outlined.
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PMID:The factorial structure of schizotypy: Part I. Affinities with syndromes of schizophrenia. 893 15

The goal of this study was to examine the effects of personality traits as measured by the NEO-PI on the quality of life (QOL) of persons with schizoaffective disorder and schizophrenia. The premise of this research is that personality traits may be important in shaping one's outlook and satisfaction with life. In a prior pilot study, personality traits were measured in persons with schizoaffective disorder and schizophrenia. In this study, the relationship between QOL and specific personality domains as assessed by the NEO-PI were studied in 21 patients. Global QOL as measured by the Lehman QOL instrument was positively correlated with Extroversion (E) and Agreeableness (A), and negatively correlated with the domain of Neuroticism (N). Global satisfaction scores were not correlated with ratings of psychoticism, paranoia or depression. These data suggest that even in psychotic conditions such as schizoaffective disorder or schizophrenia, intrapsychic factors influence one's sense of QOL. In addition, these data suggest that personality variables may differentially affect patients' satisfaction and QOL with different treatment settings.
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PMID:The relationship between personality and quality of life in persons with schizoaffective disorder and schizophrenia. 916 Nov 11

Research has indicated that stable individual differences in personality exist among persons with schizophrenia, and that they likely predate the onset of illness. Little is known, however, about whether individual differences in personality are related to levels of psychopathology. This study tested the hypotheses that levels of Extroversion, Neuroticism, and Psychoticism are associated with symptomatology. Accordingly, measures of these dimensions of personality and of symptomatology were obtained simultaneously for 113 male subjects with schizophrenia or schizoaffective disorder. Next, subjects were characterized as having high or low levels on each personality dimension and their scores on the five components of the Positive Negative Syndrome Scale were compared using multivariate and univariate procedures. Results indicate that extroverted subjects had lower levels of Positive, Negative, and Emotional Discomfort symptoms, and higher levels of Excitement symptoms than introverted subjects. Subjects with higher levels of Neuroticism had higher levels of Positive and Emotional Discomfort symptoms than subjects with lower levels of Neuroticism. No differences in symptoms were found among subjects with higher versus lower levels of Psychoticism. Results suggest individual differences in personality are associated with psychopathology in schizophrenia and may help further explain the heterogeneity widely observed in this disorder.
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PMID:Personality and psychopathology in schizophrenia: the association between personality traits and symptoms. 1022 22

Moldin et al. (1) have identified a cluster of Minnesota Multiphasic Personality Inventory (MMPI) scales that discriminate adolescents at risk for schizophrenia from those not at risk. The present study examines how well Moldin's scales predict schizophrenic decompensation in a sample of 207 Danish adolescents at high genetic risk for schizophrenia. Subjects were assessed using a modified, 304-item MMPI in 1962 (mean age= 15.1 years) and diagnosed in 10-year and 25-year follow-ups. Premorbidly, schizophrenic subjects (n=31) scored higher than subjects with no mental illness on the frequency (F) and psychoticism (PSY) scales. When paranoid and non-paranoid preschizophrenics were separated, three scales (F, Pz (paranoid schizophrenia) and PSY) significantly discriminated paranoid preschizophrenics. Discriminant function analyses confirmed these results. It is concluded that the MMPI may be useful for identifying schizophrenia premorbidly.
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PMID:MMPI variables predictive of schizophrenia in the Copenhagen High-Risk Project: a 25-year follow-up. 1040 65

This study identified the unique and primary contributions of several concurrent risk factors for poor adherence to treatment recommendations in a clinic population of individuals with chronic psychotic disorders, i.e. 48% had DSM-IV diagnoses of schizoaffective disorder, 38% had schizophrenia, paranoid type, 12% had schizophrenia, undifferentiated type, and 2% had affective disorder with psychotic features. The target cohort consisted of 87 consecutive admissions to a continuing day treatment program. As part of a services-oriented quality assurance program, clinical staff completed rating scales for all patients. These included the BASIS-32 rating scale, which consisted of the following five subscales: psychosis; depression/anxiety; impulsive/addictive behavior; relation to self and others; and daily living and role functioning, and the Working Alliance Inventory-short form (therapist version), which consisted of the following three subscales: goal; task; and bond. These data were used to identify risk factors that weaken a patient's adherence to medication and non-medication treatment during the first 2 weeks of treatment in the clinic. Medication treatment consisted of both typical and atypical neuroleptic medications, with most patients being on multiple medications. Correlational analyses suggested that many of the risk factor variables were significantly associated with poor treatment adherence. Regression analyses suggested that the degree of psychoticism was most strongly associated with poor adherence to medication treatment and that difficulties relating to self and others were the strongest predictor of poor adherence to non-medication treatment. A large-sample services research design such as this can begin to determine patterns of associations between previous identified risk factors and poor treatment adherence in individuals with chronic psychotic disorders.
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PMID:Interactive risk factors for treatment adherence in a chronic psychotic disorders population. 1070 73


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