Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The numbers of long-stay patients in Danish psychiatric hospitals were studied, based on information from the Danish cumulative psychiatric register and from the census studies of patients in Danish psychiatric hospitals, performed at 5-year intervals since 1957. In 1977, 2079 (20%) of the in-patient population which had been admitted before 1957 were still in hospitals. This 'old long-stay' group has diminished exponentially, with an annual reduction of 7%. During the period 1972--6, the number of patients who, on any given day, had been in-patients or attending as day-patients for more than 1 but less than 2 years (the 'new long-stay') varied between 847 and 1089: an average of 20 per 100 000 total population. The ratio of in-patients to day-patients was approximately 4:1. Based on the decline of the 1972 cohort during the period 1972--7, and assuming a constant 'influx' of new long-stay patients and a constant exponential decline of the cohorts, the number of new long-stay patients, including day-patients, at equilibrium was estimated to be about 4300 or 85 per 100 000 total population. About 31% will be schizophrenics and about 43% will be patients with organic disorders. Ninety-four per cent of the number at equilibrium will be reached after 16 years for the diagnostic group with the slowest decline, schizophrenia. On 1 April 1976, 3106 long-stay patients were present, accumulated since 1 April 1972. Nineteen per cent of these patients were in day-hospitals. This type of institution was used especially for younger patients with schizophrenia and reactive disorders.
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PMID:Long-stay patients in Danish psychiatric hospitals. 11

The census study in 1972, including all Danish psychiatric institutions, was the fourth in a series, the first being performed in 1957. In the 15-year period from 1957 to 1972 the total number of hospitalized psychiatric patients, including day-patients, has been almost unchanged, about 240-260 per 100,000 population. There have, however, been marked changes within the resident population. The hospital prevalence of schizophrenia has gradually decreased from 132 to 97 per 100,000 males and from 140 to 86 per 100,000 females. The decrease concerns all age groups over 35 years and is especially pronounced in females aged 35-54. In young males there has been a remarkable increase during the last 5-year period. In 1957 the schizophrenic patients constituted 62% of the male and 57% of the female patients, compared with 43% and 30%, respectively, of the patients in 1972. The downward trend which was practically linear during the first two 5-year periods slowed down during the third period but was still quite marked for the middle-aged and old groups. The patients with organic disorders (especially senile and cerebrovascular psychoses) and with reactive conditions have increased in absolute numbers as well as in rates per 100,000 population.
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PMID:Fifteen years later. A comparison of patients in Danish psychiatric institutions in 1957, 1962, 1967, and 1972. 63 5

The term glossodynia refers to all conditions with pain and dysaesthesia of the tongue and entire oral mucosa manifesting themselves in burning, prickling, itching, stinging, and other frequently bizarre sensations as well as subjective xerostomia and bad taste. In most cases psychiatric diseases are the cause of the complex of complaints whereas local and general disorders are of only minor importance. Menopausal women with atypical depression are most often affected. Schizophrenia and abnormal personality development are far less frequent in glossodynia. After exclusion or therapy of organic disorders antidepressants are the treatment of choice in glossodynia. Thereapeutic difficulties may arise in patients suffering from marked xerostomia whose complaints may intensify during therapy because of the anticholinergic effect of most antidepressants, and in neurotic persons.
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PMID:[Psychological aspects of glossodynia (author's transl)]. 67 25

A wide variation in prevalence rates of tardive dyskinesia and spontaneous orofacial dyskinesia has been reported in the elderly. To clarify these discrepancies, we studied 45 patients over the age of 60 years admitted to a short-term psychiatric unit. Standardized criteria for the diagnosis of dyskinesia were used. We found a rate of tardive dyskinesia of only 21% (7/33) in our patients having a history of neuroleptic exposure. We found no cases (0/12) of spontaneous orofacial dyskinesia. There was a significant association between tardive dyskinesia and psychiatric diagnosis, with the highest rate of tardive dyskinesia in those patients with schizophrenic disorders, followed by those with organic disorders and mood disorders, respectively. There was also a significant association between the presence of tardive dyskinesia and radiographic evidence of cortical atrophy, and a trend towards an association with leukoencephalopathy. Our results suggest that published rates of tardive and spontaneous dyskinesia in the elderly may overestimate the prevalence of these disorders, especially among geriatric patients with acute psychiatric presentations.
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PMID:Dyskinesia and neuroleptic exposure in elderly psychiatric inpatients. 135 63

Based on data from the nationwide Danish Psychiatric Case Register, trends in admission rates and treatment-day rates were studied in two Danish counties between 1977 and 1989. During the observation period, the number of available beds in the counties investigated decreased from 1.78 to 1.10 per 1000 inhabitants aged 15 years or more. Over the same period, the admission rates decreased by 20% for in-patients and 38% for day-patients. At the same time, treatment-day rates for in-patients decreased by approximately 50% and treatment-day rates for day-patients by 32%. The decrease was seen in all age groups both for admission rates and treatment-day-rates. Rates for short-term hospitalization showed a steeper decrease than those for long-term hospitalization. For schizophrenia, admission rates increased except among men under 25 years of age, and treatment-day rates decreased in all age groups. Affective disorders, neuroses, personality disorders, and alcohol and drug abuse showed the most pronounced decreases in admission rates and treatment-day rates. The same trend was seen for treatment-day rates for organic disorders. A marked decrease in admission rates was seen in the provincial towns. Treatment-day rates decreased markedly in city areas, and less so in rural areas.
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PMID:Trends in psychiatric hospitalization and changes in admission patterns in two counties in Denmark from 1977 to 1989. 149 44

It has been noted that the term "schizophrenia" is now applied to a group in many ways dissimilar to Emil Kraepelin's cases of dementia praecox and Eugene Bleuler's of schizophrenia. No detailed explanation has been offered for the difference. This article offers evidence that Kraepelin's and Bleuler's concepts were derived from a population largely suffering from organic disorders including the Parkinsonian sequelae of encephalitis lethargica; it describes the conceptual confusion which followed the introduction of the concept of post-encephalitic Parkinsonism and discusses some implications for the modern concept of schizophrenia. It is suggested that the differences between earlier and later groups of schizophrenics may be accounted for by the decline in prevalence of post-encephalitic Parkinsonism and of the neurological and behavioral sequelae of other diseases, and by the parallel unsystematic development of the concept of schizophrenia.
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PMID:Is schizophrenia what it was? A re-analysis of Kraepelin's and Bleuler's population. 225 39

Thirty-one female insanity acquittess from Connecticut were matched to a group of 31 male NGRIs. The samples were compared with regard to demographic, criminal, and clinical characteristics. Logistic regression analyses were used to determine predictors of criminal recidivism for the sample. Results indicated that women NGRIs were older, more likely to be married, less likely to be substance abusers, had less extensive criminal records, and were released from hospitals sooner than the men. A significant racial difference was noted: white women had less extensive criminal records and were hospitalized for shorter periods than minority women. Results of the logistic regression analyses showed that the strongest independent predictors of criminal recidivism were race and having a diagnosis other than psychosis (schizophrenia, affective or organic disorders). Findings support recent APA policy guidelines on the insanity defense.
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PMID:Part II: Sex differences in persons found not guilty by reason of insanity: analysis of data from the Connecticut NGRI Registry. 237 74

Schizophrenic patients in long-term care programs may not have been carefully diagnosed according to current criteria. As part of a clinical reassessment program at a state hospital, the author randomly assessed 72 patients who carried a diagnosis of schizophrenia. The diagnosis of schizophrenia by DSM-III-R criteria was confirmed in 45 patients. Various organic disorders were diagnosed in seven patients. Four patients had bipolar affective disorder, manic; one patient had schizoaffective disorder, depressed; one patient had a substance use disorder; and two had primary mental retardation or pervasive developmental disorder. Twelve patients had unclear or atypical syndromes.
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PMID:Reassessment of state hospital patients diagnosed with schizophrenia. 252 Oct 89

Schizophrenia is increasingly believed to represent a group of organic disorders which primarily, although not exclusively, affect the central nervous system. Our purpose is to review a representative sample of twentieth-century literature which speaks to the biological substrates of the syndrome. Subjects reviewed include genetic and environmental contributions to the onset of illness, early and recent findings of gross structural anomalies, and apparent histopathological alterations in cerebral cortex, cerebellar vermis, limbic system, and brain stem, as well as problems of cerebral asymmetry. Data from a diverse group of electrophysiological studies reveal several promising correlates of these areas of investigation. Despite the inconsistent nature of the findings to date, several themes have begun to emerge, including patterns of hypofrontal/hyperparietal regional cerebral flow and glucose utilization, left hemispheric dysfunction, and deficits of interhemispheric information processing. The interpretation and significance of these emerging patterns remains unclear and must await more profound insights into the nature of normal and abnormal cerebral function.
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PMID:Biological substrates of schizophrenia. 286 35

By keeping in mind that not a psychosis is schizophrenia, the primary care physician can often avoid misdiagnosis in behaviorally disturbed patients. Abnormal behavior may result from mood disorders, drug-induced psychosis and other organic disorders, personality disorders, delusional disorders, autism, or mental retardation. A long-term history is essential for correct diagnosis and treatment.
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PMID:Differential diagnosis of psychosis. A brief guide for the primary care physician. 292 77


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