Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

ADD is very well known in english speaking countries (DSM III 26-29). At first american authors have demonstrated that psycho-organic disturbances do not disappear in all cases of adulthood. Attention deficit disorders, lack of concentration, weak short time memory, word finding difficulties, visuo-motor function deficiency, lability of mood, impulsivity, lack of self-control will often be found in adults. A defective ego-function seems to be the central disorder. These patients often grow up to pathologic personalities with a propensity to neurosis, addiction, various types of psychosis, namely to schizophrenia. With consideration to the heterogeneity of ADD, MDD hyperkinetic syndrome, psycho-organic syndrome etc. accurate follow-up studies are necessary for a better delineation on this nosological concept. Therefore we have investigated the development of 78 psycho-organic patients of our out-patient department. The first examination was made at the age of 10 years and the second ten years later. We obtained the following results: 1/3 of all patients were free of mental symptoms at the main age of 23 years. 1/2 presented slight symptoms in the cognitive field and/or in the emotional life, but vocational training and social adjustment were not impaired. 1/6 of the patients showed no improvement. They had remained in their family, still need care and help and were unable to accomplish professional training. These findings were compared with those of two groups of healthy persons (20 recruits of the swiss army and 27 female students of a nursing school). The differences were statistically significant in several dimensions.
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PMID:[Are psycho-organically disordered children inconspicuous as adults? A follow-up study of 125 probands]. 242 7

This retrospective study evaluated differences between patients with first manifestation of schizophrenic psychosis (ICD 295) or paranoid syndrome (ICD 297) between the ages of 18 and 23 or 40 and 63 years. Gender-specific variations in psychopathology were also examined. The numerous analyses of variance gave few significant differences. Patients with a late onset of the disease scored higher on depressive and autonomic syndrome scales at admission, whereas patients with an early onset showed more psychosocial impairment at discharge and their stay in hospital was longer. Among schizophrenic patients only (ICD 297 excluded), only the higher score for autonomic syndrome of the older patients at admission was confirmed. Men were more apathetic at admission and discharge than were women. Excluding patients with a paranoid syndrome, these differences were again significant. Moreover, schizophrenic men had higher depressive and psycho-organic syndrome scores at discharge. The demonstration of only marginal differences between early- and late-onset schizophrenia does not support the assumption that age of onset markedly influences psychopathology.
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PMID:Age of onset in schizophrenia: relations to psychopathology and gender. 814 19

Mental morbidity in the elderly comprises mainly affective disorders (manic depressive psychosis) and psycho-organic syndrome, delirium and dementia. Psychiatric disorder occurs with physical disorder or handicap and co-morbidity is the hall-mark of geriatric medicine. The prevalence rate is around 89/1000 population. The decreasing age at onset of depression over successive generations contributed by the 'unstable genes' is discussed. Factors affecting the 'quality ageing' are highlighted. Depression, mania and suicide behaviour in the elderly are detailed. Particular attention is drawn to 'vascular depression' resulting from cerebrovascular lesions affecting the striato-pallido-thalamo-cortico-pathways. Vascular depression is characterised by a low frequency of family history of mental disorder/suicide and anhedonia and increased functional disability. Subsyndomal depression is a fairly common occurrence. Anxiety disorders in the elderly though uncommon need to be recognised. Late-onset schizophrenia and somatic hallucinosis are referred to.
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PMID:Psychiatric morbidity in the aged. 936 69