Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0036341 (
schizophrenia
)
60,220
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We will review evidence from preclinical literature that prenatal nutritional deprivation produces neurochemical, morphological, and electrophysiological effects reminiscent of those seen in clinical studies of
schizophrenia
. We will focus on effects of nutritional deficiency that are likely to have implications for
schizophrenia
. These include disruption of neurotransmitter systems such as dopamine and serotonin and dysgenesis of the hippocampal formation. Preclinical studies show enhanced release and turnover of dopamine and serotonin following prenatal and early postnatal nutritional deficiency. Morphology of the hippocampus, as well as electrophysiology and hippocampally-mediated behaviors are also altered. Although intriguing, these studies have not been conducted with
schizophrenia
in mind, and thus, outcome measures that may be more specifically related to
schizophrenia
have not been examined. We propose that further preclinical studies that examine the consequences of
prenatal nutritional deficiency
, which may lead to altered neuronal migration and other developmental abnormalities, may be useful in understanding the etiology of
schizophrenia
.
...
PMID:Prenatal nutritional deprivation as a risk factor in schizophrenia: preclinical evidence. 785 97
Emerging evidence indicates that
schizophrenia
may in some cases be a neurodevelopmental disorder, resulting in part from the effects of prenatal exposures. Studies by our group have focused attention on the potential role of
prenatal nutritional deficiency
as a potential etiological factor. Therefore, we sought to examine the biological plausibility of prenatal nutritional deprivation in the etiopathogenesis of
schizophrenia
. We conducted a review of the pertinent literature. Four lines of evidence support prenatal nutritional deficiencies as a plausible set of risk factors for
schizophrenia
: a) their effects are not incompatible with the epidemiology of
schizophrenia
; b) they have adverse effects on brain development; c) general malnutrition results in neuropathological anomalies of brain regions implicated in
schizophrenia
; and d) prenatal malnutrition affects maternal systems critical to the developing fetal nervous system. There is sufficient evidence to warrant further studies of prenatal nutritional deficits as risk factors for
schizophrenia
. A strategy for testing these hypotheses is outlined.
...
PMID:Neurobiological plausibility of prenatal nutritional deprivation as a risk factor for schizophrenia. 859 15
Epidemiological evidence indicates that prenatal nutritional deprivation may increase the risk of
schizophrenia
. The goal of these studies was to use an animal model to examine the effects of prenatal protein deprivation on behaviors and receptor binding with relevance to
schizophrenia
. We report that prenatally protein deprived (PD) female rats showed an increased stereotypic response to apomorphine and an increased locomotor response to amphetamine in adulthood. These differences were not observed during puberty. No changes in haloperidol-induced catalepsy or MK-801-induced locomotion were seen following PD. In addition, PD female rats showed increased (3)H-MK-801 binding in the striatum and hippocampus, but not in the cortex. PD female rats also showed increased (3)H-haloperidol binding and decreased dopamine transporter binding in striatum. No statistically significant changes in behavior or receptor binding were found in PD males with the exception of increased (3)H-MK-801 binding in cortex. This animal model may be useful to explore the mechanisms by which
prenatal nutritional deficiency
enhances risk for
schizophrenia
in humans and may also have implications for developmental processes leading to differential sensitivity to drugs of abuse.
...
PMID:Prenatal protein deprivation alters dopamine-mediated behaviors and dopaminergic and glutamatergic receptor binding. 1870 24
