Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Paranoid symptoms were found in 40% of patients admitted to a university general hospital psychiatric unit during a ten-month period. Fifty-eight percent of this group had frank paranoid delusions, while the rest had ideas of reference or generalized suspiciousness. Only one half of those who had paranoid delusions had paranoid schizophrenia. A significant number had affective disorders or organic brain disorder. Ideas of reference and suspiciousness were found in many patients who were not psychotic. The therapeutic implications of these findings are reported in three patients who were inadequately treated for affective disorders because the presence of paranoid symptomatology had led to an incorrect diagnosis of schizophrenia.
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PMID:Paranoid symptoms in patients on a general hospital psychiatric unit. Implications for diagnosis and treatment. 72 91

Ideas of reference are considered hallmarks of schizophrenia-related psychopathology. However, the specificity of referential thinking to schizophrenia-related psychopathology has not been examined empirically. Schizotypy reflects the latent liability for schizophrenia and is associated with referential thinking. Referential thinking may occur in other forms of psychopatholoy, such as social anxiety, which is characterized by cognitive distortions in which the thoughts and judgments of others are viewed as having reference to the self. Our primary aim was to examine the specificity of referential thinking to schizotypy. A sample of 830 college students completed a psychometric screening, of which 102 met criteria for inclusion in one of three groups: schizotypy (n=30), social anxiety (n=28), normal controls (n=44). Participants completed the Referential Thinking Scale (REF), and other measures of schizotypy (Schizotypal Personality Questionnaire, Peters et al Delusion Index, Schizophrenia Proneness Scale, Social Anhedonia Scale), affect, and intellectual functioning. The schizotypy group exhibited higher REF scores than both comparison groups. REF scores were associated with other schizotypy measures and loaded onto a positive schizotypy factor, but not onto a negative schizotypy or negative affect factor. These findings support the specificity of high levels of referential thinking to schizotypy and the construct validity of the REF.
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PMID:The specificity of referential thinking: a comparison of schizotypy and social anxiety. 1905 51