Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0036341 (
schizophrenia
)
60,220
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Schizophrenia
is a severe mental disorder that affects more than 1% of the population worldwide. Dopamine system dysfunction and alterations in glutamatergic neurotransmission are strongly implicated in the aetiology of
schizophrenia
. To date, antipsychotic drugs are the only available treatment for the symptoms of
schizophrenia
. These medications, which act as D2-receptor antagonist, adequately address the positive symptoms of the disease, but they fail to improve the negative symptoms and cognitive impairment. In
schizophrenia
, cognitive impairment is a core feature of the disorder. Therefore, the treatment of cognitive impairment and the other symptoms related to
schizophrenia
remains a significant unmet medical need. Currently, phosphodiesterases (PDEs) are considered the best drug target for the treatment of
schizophrenia
since many
PDE
subfamilies are abundant in the brain regions that are relevant to cognition. Thus, this review aims to illustrate the mechanism of PDEs in treating the symptoms of
schizophrenia
and summarises the encouraging results of
PDE
inhibitors as anti-schizophrenic drugs in preclinical and clinical studies.
...
PMID:Phosphodiesterase as a Target for Cognition Enhancement in Schizophrenia. 3253 17
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