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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Clinico-psychopathological traits of non-process forms of deviant behaviour in adolescents were studied in the framework of pathological personality formation. Two variants in the development of the disease were distinguished: favourable and unfavourable. Some differential diagnostic criteria are outlined which permit to delineate this form of borderline pathology from a debut of schizophrenia in adolescency. The study includes a consideration of the disturbed system of relationships of the personality in the adolescents examined.
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PMID:[Clinico-psychopathologic features of non-process forms of deviant behavior in adolescence]. 51 75

The authors consider some cases of postattack conditions in schizophrenia as a result of postprocess pathological personality development. A study of a group of schizoprenic patients (74 cases) made it possible to distinguish 6 variants of postprocess pathological personality (hypochondric, asthenical, development with querulous reactions, of a protracted reaction type, withdrawal from contacts, reaction of an animation type, reactions of protests). The authors propose to indicate the variant of a personality development in the framework of a functional diagnosis in order to make a more definite orientation of the rehabilitative measures.
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PMID:[Variants of postprocess pathological personality development]. 67 18

The authors describe current theoretical and clinical conceptualizations and treatment of anorexia nervosa in Russia, based on their experience in the follow-up of 800 patients. Three-quarters of the patients exhibited anorexia nervosa linked with a border-line state, and one-quarter associated with schizophrenia. Different relationships to dysmorphophobic fears were observed in the different anorexic groups. In the border-line group, follow-up study indicated that the clinical symptoms of anorexia nervosa were significantly reduced. However, the disorder preserved its connection with dysmorphophobic fears even in the remote stages of the disease, and in later stages there was an occurrence of pathological personality changes. In the second group, from the very beginning, anorexia nervosa in schizophrenia was closely connected with affective disorders, pathological body sensations, hypochondriacal complaints, and a gradual personality deterioration. As the schizophrenic defect increased, anorexia nervosa was reduced to an exhausted form of vomiting behaviour, and lost its connection with dysmorphophobic experiences.
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PMID:Anorexia nervosa as manifested in Russia. 142 17

In recent years there has been a renewed interest in the integration of descriptive and interpersonal approaches to mental illness. Much of the impetus for this stems from the introduction in 1980 of the Diagnostic and Statistical Manual of Mental Disorders, 3rd edition (DSM-III) (American Psychiatric Association 1980), with subsequent research and clinical reports documenting important interactions between Axis I syndromes and Axis II personality trait factors. While many research efforts have described comorbidity in affective and anxiety disorders, less attention has been directed toward clarifying the relationships between stable and enduring character traits and Axis I symptoms in schizophrenia. In this paper we propose that schizophrenic patients display both adaptive and pathological personality traits throughout the illness, and that clinical and research efforts to address the interactions between syndromic and personality factors ("trait-state" interactions) will further our understanding of patterns of symptom presentation and treatment response in these patients.
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PMID:Personality traits in schizophrenia. 756 41

This study compares two pathological personality disorder scales and two severe clinical syndrome scales from the Millon Clinical Multiaxial Inventory in relation to clinical change from admission to discharge on the major dimensions of the Brief Psychiatric Rating Scale. For a sample of 52 inpatients, 17 with schizophrenia, 27 with major depression, and 8 with bipolar (manic) disorder, we investigated the prognostic utility of these Millon scales for identifying clinical improvement. Findings indicated that, while the Millon scales identified admission levels of psychopathology on three Brief Psychiatric Rating Scales, the Millon inventory predicted clinical improvement on only the brief rating of Thinking Disturbance. These findings are considered in light of prognosis as a clinical research question that is distinct from diagnostic discrimination and case identification.
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PMID:Levels of psychopathology at hospital admission and discharge: the Million Clinical Multiaxial Inventory as a prognostic measure. 789 73

A preliminary but growing body of evidence supports the existence of biological substrates in personality disorders. Based on a review of the literature, the article deals with the major biological markers: genetic, cognitive, biochemical, electrophysiological and organic markers, of schizotypal and borderline personality disorders. In addition, the article compares these findings in these two types of pathological personality. In the field of genetics, we notice several indices in favour of a relationship between schizotypal personality disorder (SPD) and chronic schizophrenia. In contrast, in borderline personality disorder (BPD), indices were lacking for such a relationship between this disorder and one of the axis I diagnosis, or a clear genetic transmission. In the field of cognitive tests, we can note in both SPD and BPD, that the abnormalities which would be at the level of temporal and frontal lobes, may be implicated in the observable cognitive troubles in these two disorders. In the field of neurobiochemistry, the dopaminergic and serotonergic systems seem to be implicated in the etiology of SPD while several data point out the fact that several neurotransmitter systems (dopaminergic, serotonergic, noradrenergic and cholinergic) seem to be involved in the etiology of BPD. Finally, in the field of electrophysiology, we notice that some of these tests observed in SPD (smooth pursuit eye movements, evoked potentials, modification of the electrodermic response) seem reinforcing the relationship between SPD and schizophrenia while those observed in BPD seem reinforcing either a relationship between BPD and depression (sleep studies), or a relationship between BPD and schizophrenia (evoked potentials, smooth pursuit eye movements).
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PMID:[Biological markers in schizotypal and borderline personality disorders]. 1121 38

A study included 213 patients diagnosed with schizoaffective disorder (56.3%) or paranoid schizophrenia (43.7%). In all patients, psychotic symptoms developed under the influence of psychogenic factors. The high percentage of pathological personality disorders (50.2%), neurotic disorders (52.1%) and psychogenic depressive disturbances (53.5%) in the premorbid were found that indirectly indicates a liability to psychogenically caused endogenous psychoses. Three stages of development of schizophrenia-spectrum psychosis under the influence of psychogenic factors were singled out: psychogenic, endogenous-reactive (interim states) and endogenous psychotic disorders. Clinically heterogenic interim syndromes were specified as endogenous-reactive dysthymia (51.2%), obsessive-delusional syndrome (7.5%), hysteriform psychosis (20.2%) and endoreactive paranoia (21.2%). Psychotraumatic events caused three variants of schizophrenia-spectrum psychosis: affective, neurosis-like and paranoia. In conclusion, variants of the pathokinesis of psychogenically caused schizophrenia-spectrum psychosis predict the further course of endogenous process.
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PMID:[Development of schizophrenia-spectrum psychoses caused by psychotraumatic events]. 1936 66

Schizotypy has been proposed to be the expression of the genetic vulnerability to schizophrenia. Schizotypal features have been associated with personality dimensions found in patients with psychosis. In this study, we compared the Dimensional Assessment of Personality Pathology - Basic Questionnaire (DAPP-BQ) scores of patients with psychosis, siblings scoring higher on schizotypy (SSHS), and siblings scoring lower (SSLS). The SSHSs displayed a DAPP-BQ profile characterized by high scores in the dimensions of affective lability, anxiousness, submissiveness, social avoidance, identity problems, oppositionality, narcissism, and restricted expression, distinguishing them from the SSLS. Due to these dimensions, SSHSs are more similar to the patients' DAPP-BQ profile. The results suggest that this pathological personality profile might contribute to increase the risk of developing psychosis in siblings who have more schizotypal features.
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PMID:Schizotypy and pathological personality profile in siblings of patients with psychosis. 2126 46

The present study examined the expression of the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) schizotypal, schizoid, and paranoid personality disorder (PD) traits in daily life using experience sampling methodology in 206 nonclinically ascertained Spanish young adults oversampled for risk for schizophrenia-spectrum psychopathology. This study examined the overlap and differentiation of pathological personality traits in daily life settings, according to both diagnostic and multidimensional models. Daily life outcomes differentiated among schizophrenia-spectrum disorders. The assignment of Cluster A personality traits to positive, negative, paranoid, and disorganized dimensions provided an alternative to the traditional PD diagnoses. Positive, disorganized, and paranoid schizotypy were associated with elevated stress reactivity, whereas negative schizotypy was associated with diminished reactivity in daily life. The current diagnostic model is limited by the considerable overlap among the PD traits. Nonetheless, experience sampling methodology is sensitive enough to detect differences in day-to-day impairment and can be a powerful research tool for the examination of dynamic constructs such as personality pathology. (PsycINFO Database Record
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PMID:Expression of schizophrenia-spectrum personality traits in daily life. 2646 Oct 45

Extant literature indicates that childhood maltreatment is significantly associated with personality disorders. With the recent call for a more dimensional approach to understanding personality and pathological personality traits, the aim of the present study was to examine whether the experience of childhood maltreatment is associated with pathological personality traits as measured by the Personality Psychopathology Five (PSY-5). We analyzed data from 557 adult psychiatric patients with diverse psychiatric diagnoses, including mood disorders, schizophrenia spectrum disorders, and anxiety disorders. Hierarchical multiple regression analyses were conducted to determine the degree to which childhood maltreatment explained the five trait dimensions after controlling for demographic variables, presence of psychotic symptoms, and degree of depressive symptoms. Childhood maltreatment significantly predicted all of the five trait dimensions of the PSY-5. This suggests that childhood maltreatment may negatively affect the development of an adaptive adjustment system, thereby potentially contributing to the emergence of pathological personality traits.
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PMID:Childhood Maltreatment as Predictor of Pathological Personality Traits Using PSY-5 in an Adult Psychiatric Sample. 2826 90


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