Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report a neuropathological case of the brain of a 22-year-old male solvent abuser. He had also been diagnosed as suffering from schizophrenia. Neurohistology revealed the presence of Rosenthal fibers (RFs) in subpial and perivascular collections in the medulla, the floor of the 3rd and 4th ventricles, and also in the spinal cord. There was mild demyelination in the frontal, temporal, and parietal lobes, as well as the left dorsal column in the spinal cord. There was bilateral basal ganglia calcification. Demyelination and RFs have been the hallmark of the diagnosis of adult Alexander's disease. We urge that these are insufficient criteria for this nosological category, and suggest the alternative and more appropriate label of Rosenthal fiber encephalopathy. In view of the known toxic, clinical effects of chronic solvent abuse, and the lack of knowledge of the neuropathological effects, we also tentatively note the association of the solvent abuse with the neuropathology, but are unable to assert any causal link.
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PMID:Rosenthal fiber encephalopathy presenting with demyelination and Rosenthal fibers in a solvent abuser: adult Alexander's disease? 899 49

Astroglial cells represent a main element in the maintenance of homeostasis and providing defense to the brain. Consequently, their dysfunction underlies many, if not all, neurological, neurodevelopmental and neuropsychiatric disorders. General astrogliopathy is evident in diametrically opposing morpho-functional changes in astrocytes, i.e. their hypertrophy along with reactivity or atrophy with asthenia. Neurological disorders with astroglial participation can be genetic, of which Alexander disease is a primary sporadic astrogliopathy, environmentally caused, such as heavy metal encephalopathies, or neurodevelopmental in origin. Astroglia contribute to neurodegenerative processes seen in amyotrophic lateral sclerosis, Alzheimer's and Huntington's diseases. Furthermore, astroglia also play a role in major neuropsychiatric disorders, ranging from schizophrenia to depression, as well as in addictive disorders.
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PMID:Astrogliopathology in neurological, neurodevelopmental and psychiatric disorders. 2584 67