Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A total of 44 patients suffering from slow-progressive schizophrenia with affective disorders prevalence were examined. A long latent stage was defined as Bonn's "masked mania", two variants of the development were singled out in the active period of the disease. The first variant was characterized by depressive disorders and "mixed states" type of a clinical picture. The patients were optimistic, demonstrating high self-estimation in spite of depressive complaints, flaccidity, suppression, weakness, apathy and pseudoneurotic disorders. Accelerated development of associations was retained and motor retardation was absent Personality changes were limited by emotional and psychopathic ones. The second variant represented affective paranoia, delusional disorders formed on the basis of chronic hypomania. Its expressivity correlated with the intensity of hypomanic effect. Personality changes included thought disturbances, autization, mild decrease of the energy potential.
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PMID:[Slowly progressive schizophrenia with signs of chronic hypomania during its course]. 682 56

Visual evoked potentials (VEP) to different flash intensities were recorded at a central site (Cz) plus at homologous temporal and occipital locations in normal and unmedicated schizophrenic subjects. Schizophrenic patients showed an hemisphere asymmetry of the P100-N120 peak-trough amplitude with smaller left but larger right hemisphere amplitudes than normal. Further, two subgroups of patients were found with abnormalities lateralized to the left hemisphere. One group was found to have abnormal P100 amplitude-intensity patterns at the left temporal site while the other group showed deviant N120 amplitude-intensity patterns at the left occipital location. The clinical significance of these results can be seen in the higher nuclear schizophrenia (PSE-CATEGO) scores in the left temporal subgroup and the higher hypomania and situational anxiety scores in the left occipital group. Patients also showed slower than normal P100 and N120 peak latencies.
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PMID:Visual evoked potentials in schizophrenia. Intensity effects and hemispheric asymmetry. 683 68

The intensity needed to detect dichotic click stimuli was measured in 14 bipolar depressed patients, 19 unipolar depressed patients, and 15 normal controls. The results replicated, in unmedicated bipolar depressed patients, an earlier finding of reversed lateral asymmetry in medicated affective psychotic patients. Two new findings concern the relation of lateral asymmetry patterns to diagnostic subtypes of the Research Diagnostic Criteria and symptom ratings on the Schedule for Affective Disorders and Schizophrenia. First, patients with bipolar disorders (history of mania or hypomania) were more likely than patients with unipolar disorders to display reversed lateral asymmetry. Second, greater severity of depressive or endogenous symptoms was associated with less lateral asymmetry.
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PMID:Lateralized auditory processing in depression: dichotic click detection. 694 93

Correlational and contingency analytical techniques were used to investigate the relationship between subtest scores on the Minnesota Multiphasic Personality Inventory (MMPI) and coronary heart disease (CHD) risk factors in 1000 submariners. Groups of personality traits, both enhancing and protecting against risk of heart disease, were identified in these subjects. Personality trait patterns tending to be least associated with cardiovascular risk are tentatively identified by the three MMPI scales: psychasthenia, schizophrenia, and social introversion. On the other hand, the scales most strongly related to CHD risk in the submariner sample were denial of symptoms as measured by the K-scale, hypochondriasis, and hysteria. While the inherent inaccuracy in the prediction of CHD risk in young healty individuals limits generalization from these findings, the potential utility of the MMPI to assist in risk detection is indicated. Comparisons of cigarette smoking, coffee drinking, and alcohol consumption with personality characteristics identified by the MMPI yielded trait clusters associated with each addictive habit. Cigarette smoking and alcohol consumption tended to correlate with traits positively associated with CHD risk. The correlations between those addictive habits and MMPI subtest scores were most significant for the F-scale, which measures inordinate tendencies to exaggerated emotional symptoms, and for the psychopathic deviate and hypomania scales. Significant negative correlations were found between the amount of coffee consumed and those personality traits negatively associated wit CHD risk. These negative relationships were most significant for the MMPI scales schizophrenia and psychasthenia. Though the relationships were not necessarily construed to be causal, the contrasting modes through which these drug-associated habits appeared to relate to cardiovascular risk lend some support to the assumption that individuals with various specific sets of personality characteristics tend to incorporate these additive behaviors into their behavior repertoire in very different ways.
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PMID:Relationship of personality factors and some social habits to cardiovascular risk in submariners. 708 56

Two groups of hypothetically psychosis-prone subjects were chosen from among college students who scored deviantly high on scales of Physical Anhedonia (n = 50) or Perceptual Aberration (n = 65). Scores on these two scales had a small negative correlation, indicating that the scales identify different sets of deviant subjects. These experimental subjects and a control group (n = 66) were interviewed using a modification of the Schedule for Affective Disorders and Schizophrenia--Lifetime Version. A second interview covered social and academic adjustment. Psychotic and psychotic-like symptoms (attenuated forms of psychotic experiences) were scored on a recently devised scale of deviancy. The perceptual aberration subjects exceeded the control subjects on each of several psychotic-like experiences (auditory and visual experiences, thought transmission, passivity experiences, aberrant beliefs), as well as on depression, hypomania, social withdrawal, problems of concentration, deviances in communication and speech, and a composite score for schizotypal features. Anhedonics did not differ from controls on psychotic-like experiences but were more socially withdrawn, had less heterosexual interest and activity, and scored higher on the composite score of schizotypal features. The findings support the hypothesis that the scales identify persons who are at risk for psychosis but probably for different psychoses.
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PMID:Physical anhedonia, perceptual aberration, and psychosis proneness. 744 95

A 28-item behavioral rating scale, the Acute Psychiatric Rating Scale (APRS), was developed using factor-analytic methods for the assessment of functionally disturbed psychiatric inpatients. Fifty-eight staff rated 74 patients on the scale. Seven factorial dimensions were extracted comprising neuroticism, aggression, emotional withdrawal, cognitive impairment, schizophrenia, hypomania and self-injuriousness. The scale was evaluated in 4 different psychiatric inpatient units: two acute admission wards, an intensive care unit and a regional secure unit. Behavioral ratings on the scale were related to several patient demographic and treatment variables, including age, sex, marital status, legal status, length of admission and electroconvulsive therapy. The scale was found to possess a clear factorial structure, good interrater reliability and promising clinical validity for further research use in psychiatric inpatient settings.
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PMID:An acute psychiatric rating scale for the clinical assessment of functionally disturbed inpatients. 767 38

Our study examined the relationship between the Minnesota Multiphasic Personality Inventory (MMPI) and the Scale for the Assessment of Positive Symptoms (SAPS; Andreason, 1984) and the Scale for the Assessment of Negative Symptoms (SANS; Andreason, 1983) in patients who met the Diagnostic and Statistical Manual of Mental Disorders (3rd ed., rev.; American Psychiatric Association, 1987) diagnostic criteria for schizophrenia (n = 125). A significant correlation was found between the SAPS Delusions scale and Scale 6 (Paranoia), the SAPS Positive Thought Disorder Scale and Scale F (Infrequency), and the SAPS Positive Thought Disorder and Scale 9 (Hypomania). Additional analysis also shows, however, that severity of symptoms was the best predictor of MMPI scores. Consistent with previous studies, the MMPI appears useful for screening but not for the detailed evaluation of symptomatology of schizophrenic patients.
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PMID:Correlations between the MMPI and the Scale for the Assessment of Positive Symptoms and the Scale for the Assessment of Negative Symptoms in schizophrenic patients. 796 72

Abnormally low tyramine test values are known to be markers for vulnerability to unipolar, but not bipolar, endogenous depression. In the present study, 37 women with recent postnatal depression (25 major, 12 minor) and 22 puerperal controls with no depressive disorder, all assessed by Schedule for Affective Disorder and Schizophrenia (SADS-L) interview, together with 17 other controls, underwent the test. No significant differences in tyramine sulfate output were demonstrated between the different groups. Those subjects with endogenous features according to Newcastle score (n = 7) or Research Diagnostic Criteria (RDC) (n = 6) also had normal output. Thus, the tyramine test does not appear to be a useful marker for vulnerability to postnatal depression. Over half the subjects recalled that their postnatal depression had started in the first 2 weeks postpartum. Of the total of 62 postpartum subjects interviewed with the SADS-L, ten recalled a period of euphoria in the first postpartum week, which met RDC for hypomania and eight of them went on to become depressed postnatally. An additional patient from the total group was hospitalized with mania.
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PMID:The tyramine test is not a marker for postnatal depression: early postpartum euphoria may be. 814 83

Using diagnostic stability data from independent diagnostic interviews conducted 6 years apart, we determine which diagnoses are predictive of diagnoses 6 years later. Logistic analysis using categorical predictors is used to establish ordinal relationships and to suggest diagnostic hierarchies. The multiple-threshold multifactorial model is used to estimate the within-person correlation over time. Rather than use a simple dichotomy of "affected" or "unaffected," we provide odds ratios for mania, hypomania, and major depressive disorder in terms of diagnostic hierarchies, allowing a ranking of these diagnoses. This division increases the information for genetic studies or studies of a phenotype with correlated biological or environmental continuous covariates. The diagnosis of schizophrenia shows remarkable specificity across occasions. We find significant error in a cross-sectional assessment in this nonclinical sample. Assuming a multifactorial model, the proportion of variance in liability due to assessment error is approximately 30 percent under all schemes considered. The use of repeated measures in family studies is thus strongly recommended.
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PMID:Stability of diagnosis: application to phenotype definition. 819 14

Among a sample of 40 severe migraine sufferers, males and females displayed common personality profiles. Both sexes exhibit heightened scores on those MMPI clinical scales associated with neuroticism (hypochondriasis, depression and hysteria). Female migraine sufferers were further characterised by elevated scores on the primary scales constituting the psychotic tetrad (paranoia, psychaesthenia, schizophrenia, and hypomania). Migraine females appeared to differ from male patients with respect to a dimension associated with sex-role conformity (loaded on the L-scale and masculinity-femininity). The implication of these results are considered.
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PMID:MMPI profiles of male and female migraine sufferers. 821 5


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