Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We investigated the reliability of the Education-related Self Efficacy Scale (ESS-40), a measure of self-efficacy at a core task level designed for people with psychiatric disabilities. Sixty community residents with schizophrenia or schizoaffective disorder participated. The ESS-40 was administered twice via telephone interview. Short cycle test-retest reliability was very good for the total score and most items. The measure demonstrated signs of a coherent internal structure, adequate face validity, good client acceptability, and promising utility. The reliability evidence supports its use in community mental health services and in psychiatric rehabilitation settings. Sensitivity and predictive validity require further investigation.
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PMID:The reliability of an education-related self-efficacy scale for people with psychiatric disabilities. 2014 Jun 44

The purpose of this study was to develop a semistructured interview for the Japanese version of the Early Signs Scale (ESS-JI), as well as to examine its reliability and validity. We conducted a cross-sectional study in Japan. Participants were recruited from a psychiatric clinic. The survey included 25 participants with schizophrenia; of these, 21 participants gave informed consent. For the analysis, we used data from 15 outpatients who had no missing values on the ESS-JI. Of the participants, 70% were female, and the mean age was 41.2 years. The ESS-JI was developed by the authors using a translation-back-translation procedure. Internal consistency was assessed by Cronbach's alpha coefficients, and test-retest reliability was assessed by Pearson's correlation coefficients. Correlations with other scales, such as the Behaviour and Symptom Identification Scale (BASIS-32) and the Self-Efficacy for Community Living Scale (SECL), were used to examine the concurrent and construct validity of the ESS-JI. Cronbach's alpha coefficients were high for the ESS-JI. Pearson's correlation coefficients also indicated good test-retest reliability. The ESS-JI was significantly and positively correlated with the BASIS-32. In contrast, the ESS-JI had a significant negative correlation with the SECL. This study confirmed the reliability and validity of the ESS-JI for outpatients with schizophrenia.
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PMID:Reliability and validity of the Japanese semistructured interview version of the Early Signs Scale (ESS-JI) for outpatients with schizophrenia (study 1). 2137 Dec 30

The PHR (Pam/Highwire/RPM-1) family of ubiquitin E3 ligases plays conserved roles in axon patterning and synaptic development. Genetic modifier analysis has greatly aided the discovery of the signal transduction cascades regulated by these proteins. In Caenorhabditis elegans, loss of function in rpm-1 causes axon overgrowth and aberrant presynaptic morphology, yet the mutant animals exhibit little behavioral deficits. Strikingly, rpm-1 mutations strongly synergize with loss of function in the presynaptic active zone assembly factors, syd-1 and syd-2, resulting in severe locomotor deficits. Here, we provide ultrastructural evidence that double mutants, between rpm-1 and syd-1 or syd-2, dramatically impair synapse formation. Taking advantage of the synthetic locomotor defects to select for genetic suppressors, previous studies have identified the DLK-1 MAP kinase cascade negatively regulated by RPM-1. We now report a comprehensive analysis of a large number of suppressor mutations of this screen. Our results highlight the functional specificity of the DLK-1 cascade in synaptogenesis. We also identified two previously uncharacterized genes. One encodes a novel protein, SUPR-1, that acts cell autonomously to antagonize RPM-1. The other affects a conserved protein ESS-2, the homolog of human ES2 or DGCR14. Loss of function in ess-2 suppresses rpm-1 only in the presence of a dlk-1 splice acceptor mutation. We show that ESS-2 acts to promote accurate mRNA splicing when the splice site is compromised. The human DGCR14/ES2 resides in a deleted chromosomal region implicated in DiGeorge syndrome, and its mutation has shown high probability as a risk factor for schizophrenia. Our findings provide the first functional evidence that this family of proteins regulate mRNA splicing in a context-specific manner.
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PMID:Systematic analyses of rpm-1 suppressors reveal roles for ESS-2 in mRNA splicing in Caenorhabditis elegans. 2519 63