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Target Concepts:
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Query: UMLS:C0036341 (
schizophrenia
)
60,220
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Whereas etiological heterogeneity of the various types of
schizophrenia
has been repeatedly proposed, relatively few attempts have been made to separate the component diseases. Using a strategy focusing on bimodal distributions within several relevant domains of
schizophrenia
, we demonstrate that currently available data on
schizophrenia
patients are consistent with the hypothesis that some of these patients have an ongoing neurodegenerative disease, whereas others do not. We review studies (longitudinal and cross-sectional) documenting progressive increases in ventricular size, accelerated loss of brain tissues, progressive delays in treatment response, and neurochemical (magnetic resonance spectroscopy) and neurophysiological (P300) indices, all of which are consistent with ongoing
cerebral degeneration
in a significant subgroup of
schizophrenia
patients. These lines of evidence converge on a conceptualization of
schizophrenia
as being composed of several etiologically distinct processes, with one subset of psychotic patients evidencing progressive brain degeneration. We conclude with a discussion of possible etiologies for this condition.
...
PMID:Heterogeneity of the psychoses: is there a neurodegenerative psychosis? 971 29
