Gene/Protein
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Pivot Concepts:
Gene/Protein
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Drug
Enzyme
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Target Concepts:
Gene/Protein
Disease
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Query: UMLS:C0036341 (
schizophrenia
)
60,220
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Recent bio-developmental models of shyness traits (Schmidt, L.A., Fox, N.A., 1998. The development and outcomes of
childhood shyness
. Annals of Child Development 13, 1--20; Schmidt, L.A. Fox, N.A., 1999. Conceptual, biological, and behavioural distinctions among different types of shy children. In: Schmidt, L.A., Schulkin, J. (Eds.), Extreme Fear, Shyness, and Social Phobia: Origins, Biological Mechanisms, and Clinical Outcomes. Oxford University Press, New York, pp. 47--66) have proposed that
childhood shyness
and early sociability troubles may be a precursor to pervasive social dysfunction in adulthood. An important question in testing the vulnerability model is to determine the severity of shyness among adults who have a serious social dysfunction, such as individuals diagnosed with
schizophrenia
. The Cheek and Buss Shyness and Sociability Scales (Cheek, J.M., Buss, A.H., 1981. Shyness and sociability. Journal of Personality and Social Psychology 41, 330--339) and the Reznick Retrospective Self-report of Inhibition (Reznick, J.S., Hegeman, I.N., Kaufman, E.R., Woods, S.W., Jacobs, M., 1992. Retrospective and concurrent self-report of behavioural inhibition and their relation to adult mental health. Development and Psychopathology 4, 301--321) were administered to 23
schizophrenia
outpatients and 23 control subjects matched for age and sex. The results indicated that individuals with
schizophrenia
showed significantly more shyness (P<0.004), lower sociability (P<0.02) and more recollections of childhood social troubles (P<0.007) compared with the control group. Within the
schizophrenia
group, both shyness traits (P<0.04) and limited sociability (P<0.01) were clearly associated with interpersonal dysfunction, while significant correlations were also found between troubled sociability and negative symptoms (P<0.05). The findings of shyness traits, impaired sociability and more recollections of childhood social difficulties among stable outpatients diagnosed with
schizophrenia
are consistent with predictions based on a bio-developmental shyness vulnerability model.
...
PMID:Shyness, sociability, and social dysfunction in schizophrenia. 1129 86