Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The following self-rating inventories were administered to 613 subjects (289 psychically ill patients and 324 healthy persons): The Basel Mood Inventory (BBI), the Freiburg Personality Inventory (FPI), the Giessen-Test (GT), the Complaint-List (HHM), and the Paranoid-Neuroticism-Depression-Scale (PND-S'). The main interest was put on examining the dimensionality of each inventory separately and all the inventories combined. The results are discussed with respect to the practical applicability. FPI and GT proved as two polyvalently applicable personality inventories (clinically as well as non-clinically) whose factorial structure is essentially verified. It was justified to eliminate "N" (neuroticism) from the PND in the newly revised version. Although "P" (paranoid) covers only a particular domain of paranoid tendencies the new test version (PD and PD') will be valuable in clinical use for group differentiation (a.o. for global diagnoses of depression and schizophrenia) in longitudinal as well as cross-sectional studies. The HHM covers mood state variables additionally, little differentiated though. The newer parallel forms suffer from the same deficiency. It could be confirmed that the BBI measures a particular mood-drive dimension and thus can be used independently or in combination with multidimensional personality inventories in longitudinal studies.
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PMID:[Self-evaluation questionnaires--factorial structure and indications for general practice]. 671 85

We detected a PstI restriction fragment length polymorphism in the 5'-non-coding region of the dopamine D4 receptor gene (DRD4), making it the seventh known polymorphism for DRD4. DNA polymorphisms in the putative regulatory region of DRD4 are of interest because of the reported six-fold increase in D4 receptors in post-mortem schizophrenic brain tissue [Seeman P, Guan HC, Van Tol HHM (1993) Nature, 365, 441-445]. We found no difference in the PstI allele frequencies between DSM-III-R schizophrenia patients (0.76 and 0.24, n = 41), and matched control Caucasians (0.77 and 0.23, n = 46). The PstI DRD4 polymorphism has potential use in linkage and association studies with neuropsychiatric and cardiovascular disorders.
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PMID:A PstI restriction fragment length polymorphism in the 5' untranslated region of DRD4 is not associated with schizophrenia. 914 24