Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Amniocentesis, the obtaining of a small amount of amniotic fluid with fetal cells for testing, has made it possible to diagnose some diseases in utero early enough in pregnancy to permit abortion. The current major indications for prenatal diagnosis are Down's syndrome (Trisomy 21), numerous rare inborn errors of metabolism, and neural tube closure defects. Chromosoml screening in prisons has identified men with sex chromosomal abnormalities with higher frequency than in the general population, e.g., the XYY syndrome and the XXY or Klinefelter syndrome. Some of the disorders of sexual differentiation of behavioral interest range from hermaphrodites, the Turner syndrome, congenital adrenal hyperplasia, and testicular feminization. Depression and schizophrenia are 2 psychiatric disorders that are probably influenced by genetic factors but cannot be tested for at present. Behavioral syndromes associated with abnormal chromosomes or biochemical markers may be suitable for early detection int he future. There are many social and psychological problems in testing and counseling for genetic and chromosomal diseases.
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PMID:Intrauterine diagnosis and genetic counseling in psychiatry. 79 88

The authors examined 4446 patients in mental hospitals. Among these patients 15 displayed the 47 XYY syndrome and 3 with mosaicism 46 XY/47 XYY. A study of these patients showed that in 5 cases they were qualified as schizophrenic. They were study died from 2-5 years. In 4 cases the diagnosis of schizophrenia was not confirmed. In one case the authors diagnosed the disease as an atypical form of schizophrenia. The clinical traits of the disease in this case are associated with a supplementary Y somasomia.
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PMID:[Schizophrenic and schizophrenic-like manifestations in syndrome 47, XYY]. 101 21