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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Epidemiological studies, animal studies, and clinical studies yielded conflicting results concerning a supposed association between increased risk for suicide and violence, and low serum cholesterol levels. Until now, no data has been available for patients with schizophrenia, a disorder with a well-known increased risk of violence. Correlations of serum cholesterol levels at admission and measures of violence were investigated in 103 consecutively admitted patients (44 males, 59 females) of a general psychiatric admission unit. Seventy subjects were diagnosed as suffering from schizophrenia or schizoaffective disorder (ICD-10 F 20, F25), and 33 were diagnosed as suffering from non-psychotic disorders (mainly personality disorders). The level of total exhibited violence during the inpatient treatment period was measured in each patient by the Modified Overt Aggression Scale (MOAS), the Social Dysfunction and Aggression Scale (SDAS), the Staff Observation Aggression Scale (SOAS), and the Violence Scale (VS). Correlations of all violence measures were high (0.75-0.90), but no correlation was found with cholesterol levels, neither for psychotic nor for non-psychotic subjects, neither for men nor for women. The hypothesis of associations of violence and cholesterol levels is not supported by the data.
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PMID:No correlation of serum cholesterol levels with measures of violence in patients with schizophrenia and non-psychotic disorders. 1057 67

Factors leading to risk for violence were evaluated in an offender population of 36 male offenders including 18 Violent, e.g., assault, threatening and 17 nonviolent (break and enter, theft), and 17 nonoffenders. Their scores on the Psychopathy Checklist Revised, Violence Risk Scale-Experimental Version 1, Minnesota Multiphasic Personality Inventory-168, and the Porteus Maze tests showed scores for the inmates with violent offenses were elevated on Psychopathic Deviate, Paranoia, Schizophrenia scales of the Minnesota Multiphasic Personality Inventory, violence risk of the Violence Risk Scale, showed psychopathic orientation on the Psychopathy Checklist Revised, and had a lower test age quotient score on the Porteus Maze test.
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PMID:Risk factors in violent and nonviolent offenders. 1061 97

Schizophrenia is a chronic, disabling disease of mind and behavior. Since some schizophrenics are prone to violence, nursing students devised a safety risk assessment tool to help health care personnel screen clients in acute care settings who may be at risk for violent behavior. The tool is accurate, quick, and user-friendly, and it enhances communication among members of the multidisciplinary health care team. The results obtained from the assessment tool guide nurses and other health care team members in implementing appropriate interventions. Future research and pilot studies are warranted to increase the reliability and validity of this tool.
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PMID:A student-developed tool for assessing safety in schizophrenic patients. 1069 Jan 15

Substance use disorders occur in approximately 40 to 50% of individuals with schizophrenia. Clinically, substance use disorders are associated with a variety of negative outcomes in schizophrenia, including incarceration, homelessness, violence, and suicide. An understanding of the reasons for such high rates of substance use disorders may yield insights into the treatment of this comorbidity in schizophrenia. This review summarizes methodological and conceptual issues concerning the study of substance use disorders in schizophrenia and provides a review of the prevalence of this co-occurrence. Prevailing theories regarding the co-occurrence of schizophrenia and substance use disorders are reviewed. Little empirical support is found for models suggesting that schizophrenic symptoms lead to substance use (self-medication), that substance use leads to schizophrenia, or that there is a genetic relationship between schizophrenia and substance use. An integrative affect-regulation model incorporating individual differences in traits and responses to stress is proposed for future study.
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PMID:Substance use disorders in schizophrenia: review, integration, and a proposed model. 1072 98

We report a cross-sectional descriptive study of 90 new long-stay patients (NLS) (i.e. those who had been resident for six months to three years in Permai Mental Hospital, Johor) and studied from April to June, 1995. The age of this sample ranged from 18 to 85 years. Two subgroups were observed (i.e. younger NLS patients aged 18 to 34 years and older NLS patients aged 35 to 85 years). Among the younger NLS patients, the commonest diagnosis was schizophrenia (51.2%), followed by mental retardation with related problems (24.4%). Sixty-one percent of these younger patients had a history of serious violence or dangerous behaviour. Older NLS patients were likely to have a diagnosis of schizophrenia (79.6%), followed by mood disorder (6.1%) and dementia (4.1%). Forty seven percent of these older group had history of danger to others and 57.1% were at moderate or severe risk of non-deliberate self-harm. Focusing on the schizophrenic patients, all of them had some form of psychopathology, either positive, negative or general symptoms and about one-fourth were assessed to pose a risk for aggression.
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PMID:Audit of new long-stay patients in Permai Mental Hospital, Johor. 1096 71

Very little is known about the nature of serious sex offences against women by psychotic men. This study aimed to examine such offences by carrying out a search of Home Office records for all 80 male restricted hospital order in-patients with schizophrenia, resident in any hospital in England and Wales during May 1997, with an index conviction for a contact sex offence against a woman, committed whilst psychotic. Offences peaked in the afternoon, but were proportionally distributed according to day and month. Most (47/59%) offences occurred indoors, with over half of these in the victim's home. Assailants were strangers in 49 (61%) offences. Offences involving strangers were more likely to occur outdoors and without any preceding social interaction compared to those involving assailants known to their victims. Offenders' speech tended to be impersonal, with little attempt at intimacy. Offence sexual behaviours were: breast/genital fondling 63 (79%), vaginal intercourse 42 (52%), fellatio eight (10%), anal intercourse seven (9%), and cunnilingus six (8%). Excessive violence or bizarre behaviour occurred in a minority of offences. The findings are discussed with reference to the literature on sex offences by men without mental illness. The data do not support anecdotal or popular images that most psychotic sex attackers behave in an exceptionally violent or bizarre manner.
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PMID:Offence characteristics of psychotic men who sexually assault women. 1097 84

A study of mortality for all patients with a first hospital diagnosis of schizophrenia in Stockholm County, Sweden, during 1973 to 1995 was performed, by linking the in-patient register with the national cause-of-death register. Overall and cause-specific standardized mortality ratios (SMR) were calculated by 5-year age classes and 5-year calendar time periods. The number of excess deaths was calculated by reducing the observed number of deaths by those expected. Our results confirmed a marked increase in mortality in schizophrenia both in males and females. Natural (somatic) causes of death was the main cause of excess deaths, with more than half of the excess deaths in females, and almost half of the excess deaths in males. Suicide was the specific cause of the largest number of excess deaths in males, while in females it was cardiovascular disease. SMRs were increased in both natural and unnatural causes of death, with 2.8 for males and 2.4 for females for all deaths, but were highest in suicide with 15.7 for males and 19.7 for females, and in unspecified violence with 11.7 for males and 9.9 for females. SMRs in suicide were especially high in young patients in the first year after the first diagnosis.
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PMID:Mortality and causes of death in schizophrenia in Stockholm county, Sweden. 1097 69

A review of medical charts over a 1-year period was carried out in a population of 213 Taiwanese psychiatric inpatients that included 106 patients with schizophrenia. In subgroup analyses within the group of patients with schizophrenia, no significant differences in serum cholesterol levels were found between paranoid and non-paranoid schizophrenic patients, between patients with and without physical violence, or between patients who had and had not made a suicide attempt.
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PMID:Serum cholesterol levels in paranoid and non-paranoid schizophrenia associated with physical violence or suicide attempts in Taiwanese. 1106 90

The catechol-O-methyltransferase (COMT) gene was thought to be a candidate gene for schizophrenia because of its role in inactivating dopamine. This study examined the relationship between a functional polymorphism (val158met) of the COMT gene, schizophrenia and its associated behaviors. One hundred and ninety-eight Chinese schizophrenic patients and 188 controls were genotyped by polymerase chain reaction restriction fragment length polymorphism. Of the schizophrenic patients, 72 had a history of violence and 62 had a history of suicide attempts. The results failed to show significant association between val158met polymorphism and schizophrenia, violence or suicide. However, our results showed a significant difference in age at disease onset among different genotypes (F = 5.501, p = 0.005).
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PMID:Association analysis of a functional catechol-o-methyltransferase gene polymorphism in schizophrenic patients in Taiwan. 1115 Aug 92

Serotonergic pathways have been implicated in impulsive and aggressive behavior. Polymorphisms in the regulatory region of the serotonin transporter (5-HTT), in intron 7 of the tryptophan hydroxylase (TPH) gene and in the MAOA gene were previously reported to be associated with mood and anxiety disorders, impulsivity and aggression. In this study, we analyzed these polymorphisms in men and women with schizophrenia or schizoaffective disorder (n = 84) who met our criteria for violence (history of two or more assaults on others) or nonviolence (no history of either assaultive or threatening behavior). In males, a modest association between TPH genotype and history of violence (chi-square test = 6.703, degrees of freedom = 2, P = 0.035) was not statistically significant after correction for multiple comparisons (corrected P = 0.21). The TPH L allele was more frequent in violent males (chi-square = 5.323, degrees of freedom = 1, P = 0.021) but this difference also failed to withstand correction (corrected P = 0.126). No significant associations were found for either the 5-HTT or MAOA polymorphisms in males or females. These results tend to support previous reports by New et al. (1996; 1998) of an association between the TPH L allele and impulsive aggression in males with personality disorder, but larger studies are needed.
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PMID:An association between a polymorphism of the tryptophan hydroxylase gene and aggression in schizophrenia and schizoaffective disorder. 1120 46


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