Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study relates violent behavior of schizophrenic inpatients to demographic, historical, EEG, neurological, and neuropsychological variables. Patients were classified into high (N = 28), low (N = 27), or no (N = 34) violence groups. There were no significant differences among the groups on demographic or historical variables, except for prevalence of violent crime, which was higher in both violent groups than in nonviolent patients. Neurological and neuropsychological abnormalities differentiated the groups, with the high violence group evidencing more abnormalities than the other two groups in the area of integrative sensory and motor functions. The authors suggest that violence as well as neurological and neuropsychological deficits may characterize a more severe form of schizophrenia.
 ...
PMID:Neurological impairment in violent schizophrenic inpatients. 229 84

Clinical analyses of 19th century psychiatric practice have been limited by the paucity of available records. Using the richly detailed casebooks of Ticehurst House Asylum, it was possible to study over 600 admissions and assess them using the Research Diagnostic Criteria. Over 80% of cases conformed to recognizable psychiatric illness, mainly schizophrenia and manic-depressive psychosis. Movement disorder, often equivalent to tardive dyskinesia, was noted in nearly one-third of schizophrenics. Violence, masturbation and severe psychopathology were also common features. The implications of these findings in terms of treatment, diagnosis and the rise of the asylum are discussed.
 ...
PMID:Rich and mad in Victorian England. 265 31

Ten patients suffering from chronic psychiatric disorder with violence were admitted for stereotactic multitarget limbic leucotomy. Eight of them were schizophrenia, one was paranoid, and one was mania. In operation, thermococagulative lesions were made bilaterally in the amygdala, the anterior cingulate region and the innominate region. The criteria of the patients selected for the operation, the operative procedure and evaluation of the results are introduced. Five patients achieved significant improvement and three patients showed some improvement after operation. The complications included, temporary mild paraplegia (in four cases) and sphincter disturbances (in five cases) in the first two weeks postoperation. The choice of targets and possible causes of complications are discussed.
 ...
PMID:[A preliminary report on stereotactic multi-target limbic leucotomy]. 268 47

The relationship between violent behavior and length of hospitalization was studied in a retrospective chart review of 253 patients admitted to a university-based acute inpatient unit. Violent behavior was defined as physical attacks on persons or fear-inducing behavior before admission or during initial hospitalization, and its value as a predictor of length of stay was assessed in multiple regression analyses that also included 20 demographic and clinical variables. Violence per se was not an important predictor of length of stay, but violence associated with a diagnosis of schizophrenia was an important predictor. Schizophrenic patients who physically attacked others shortly after admission were more likely to have an extended stay than other patients. The study demonstrates the importance of considering clinically meaningful patterns, such as the interaction between diagnosis and violent behavior, when predicting length of stay.
 ...
PMID:Violent behavior and length of psychiatric hospitalization. 275 70

We undertook a retrospective survey of assaultive behavior in 140 psychiatric inpatient research volunteers who had not previously responded well to neuroleptic treatment. Forty-one of 97 patients with schizophrenia became assaultive during their hospitalization, whereas only four of 43 patients with other diagnoses became assaultive (p less than .0001). Most assaults were not a significant threat to the attacked person, but a small number were highly dangerous. Assaultive patients were significantly younger, and a greater proportion had a previous history of violence, compared with nonassaultive patients. A previous history of violent behavior was linked to more previous hospitalizations, indicating that such behavior might be associated with a poor prognosis.
 ...
PMID:Violent behavior in schizophrenic inpatients. 288 Sep 27

There is increasing evidence that certain groups of mentally ill patients are at greater risk of behaving violently. The majority of the violence occurs in established cases of schizophrenia who have drifted out of ongoing care and supervision. Improved community services and more rigorous follow-up of at-risk groups could both improve the quality of life for these patients and reduce the chance of their acting violently.
 ...
PMID:Violence and mental disorder. 306 18

Among custodially remanded male prisoners from Greater London and its surrounds, in 1979-1980, nearly 3% (63 men) were aged 55 or over, about one third of these being over 65. More than 40% were detained on theft charges and few for more serious offences, although serious violence was not unknown and nearly one-fifth of those 65 or over were subsequently convicted of non-violent sexual assaults. Like their younger counterparts, less than one-fifth of those aged 55 or over appeared to be first-time offenders. About half of the men of 55 or over had active symptoms of psychiatric disorder on entering the prison and about half had some form of physical disorder, twice the rates for those under 55. Psychosis and alcoholism were the major psychiatric problems; 27% were alcoholics, to the extent of showing withdrawal symptoms on or soon after entering prison. Schizophrenia was less common than the younger age groups, but affective psychosis more so; 37% of the older men had a major functional psychosis. Two-thirds of the 55-64 age group and over three-quarters of the over 65s were without an address; most of both groups were personally isolated.
 ...
PMID:Elderly offenders. A study of age-related factors among custodially remanded prisoners. 316 68

A case of schizophrenia associated with complex partial seizure disorder and postictal violence, both refractory to conventional treatment, is presented. Adjunctive treatment with clonazepam resulted in the cessation of the seizures and of persistent, violent hallucinations. The theoretical implications for possible mechanisms underlying at least some types of aggressive behavior are discussed.
 ...
PMID:Antiaggressive effect of adjunctive clonazepam in schizophrenia associated with seizure disorder. 334 99

Suicidal behavior is a relatively common and serious problem in those with alcohol and drug problems. We compared demographic and clinical characteristics of 123 alcohol rehabilitation patients with and without a history of suicide attempts, using the Schedule for Affective Disorders and Schizophrenia-Lifetime version. Younger age was significantly related to suicide attempts, as were drug disorders, panic attacks, antisocial symptoms, and alcohol-related problems such as violence, withdrawal symptoms, and personal or occupational loss. Untreated suicide attempts were characterized by less serious suicidal intent and medical threat to life. However, alcohol- or drug-abusing individuals who have not sought treatment for suicidal behavior but who continue to drink or use drugs may be at special risk for completed suicide.
 ...
PMID:Treated and untreated suicide attempts in substance abuse patients. 336 44

To make informed decisions about allocation of resources between state hospitals and community services, it is necessary to have comparable data on patients being served in both kinds of settings. Using a random sample of 611 severely impaired young adult patients with major mental illnesses, a study in Missouri compared those who were treated in state-operated facilities with those treated in private, not-for-profit community mental health centers that received state funds. A major finding was that young adult patients were more likely to be treated in a state-operated facility, and that 89 percent of inpatient admissions of this group were made to state-operated facilities. Compared with patients seen in the centers, those served by state facilities were more likely to have histories of arrests or violence, to be minority-group members, to be poor or unemployed, to have a diagnosis of schizophrenia, and to come from more urbanized areas. Of the 26 percent of the sample defined as chronic patients, 73 percent were treated at state-operated facilities.
 ...
PMID:Who really treats the severely impaired young adult patient? A comparison of treatment settings. 359 98


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>