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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Haas was the first medical doctor from the Rhineland who was trained at the Berlin Psychoanalytic Institute and established himself as a "specialist for psychoanalysis" in Cologne. For nearly ten years he had a flourishing practice there with a particular interest in the treatment of schizophrenia. He was Jewish and in 1936 he emigrated to England where he was the first and for a long time only psychoanalyst in Birmingham. He specialised in treating patients with personality disorders and psychosomatic diseases and was increasingly consulted as a forensic expert. As a result of his association with a hospital and with the university, he was instrumental in the foundation of the West Midlands Institute for Psychotherapy. At the time of his death in 1990, the psychoanalytic study group of Cologne lacked any knowledge of his life or work.
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PMID:[A forgotten chapter in the prehistory of psychoanalysis in Cologne. The emigration of Hans Erich Haas (1896-1990)]. 1799 42

Plants have been a source of therapeutic agents for more than 5000 years. Approximately 25% of the modern medications are developed from plants. Botanical drugs, simply defined as clinically validated pharmaceuticals of plant origin, typically contain a multi-component composition derived from herbal practices. An obvious advantage of botanical drugs is their history of use and hence, that the therapeutic window has already been understood through experience. Following vigorous scientific validation and appropriate regulatory procedures, some of the ancient remedies may prove to be useful in mitigating certain ailments (e.g., Alzheimer's disease, schizophrenia, metabolic syndrome, etc.) where contemporary therapies often lack desired effectiveness. Such a complementary approach has received tremendous attention among medical professionals, governmental agencies and the general public across the world. A few recently approved botanical prescriptions in the USA and Europe, albeit for topical application, have opened a window of opportunity in terms of regulatory passages in the West. One of the major challenges we face is the standardization of biological materials from natural sources. New technologies to modernize traditional herbs into mainstream pharmaceutical products are being evaluated with the ultimate goal of maximizing the opportunities and overcoming the challenges.
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PMID:Botanical drugs: challenges and opportunities: contribution to Linnaeus Memorial Symposium 2007. 1817 74

This paper addresses the issue of employment discrimination against individuals with a history of schizophrenia. There are three illustrations, two of which come from Asian countries, where the discrimination tends to be more openly expressed than in the West. Maintaining competitive employment is crucially important for individuals who are recovering from schizophrenia; indeed, employment is an inherent part of recovery. The paper makes recommendations for clinicians, advocates, patients, and employers.
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PMID:Employment discrimination against schizophrenia. 1908 91

Received wisdom and a substantial body of epidemiological work indicate that early psychosis bodes ill for matrimonial prospects. Using follow-up data from ISoS, the WHO-Collaborative International Study of Schizophrenia, we confirm an earlier local finding that marital success, 15 years after first-break psychosis, is quite favourable in India: 74% for women, 71% for men, compared with elsewhere: 48% for women, 28% for men. This comparative advantage applies to both marriages contracted after onset of psychosis as well as those that survive it, and is the more remarkable for occurring in a culture where the stigma attached to mental illness with regard to marriage is especially heavy. The presence of children and availability of household assistance both appear to enhance odds of successful marriage. That expressed worries about marriage proved so poor a guide to actual performance (and, indeed, survive living proof to the contrary in the families reporting the stigma) suggests that inquiries into stigma should be reworked as larger inquiries into local moral economies of worth. In the dharma-governed world of Hindu India resistance to the cultural opprobrium attached to madness is not a strategic assault on a structured source of shame and discrimination, but a tactical manoeuvre in the name of a higher cultural good - family, the lineage and the social order. Restoring this social basis of self-respect repairs what would otherwise be a disabling breach in the normal maturation process; developmental continuity, in turn, may help explain India's favourable rates of recovery from psychotic disorder. By the same token, the lack of coordinate processes in cultures where transitions to adulthood are poorly marked and post-hospital expectations are low may help to explain the common experience of 'social defeat', and poor outcome, in the lives of former psychiatric patients in the West.
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PMID:To have and to hold: a cross-cultural inquiry into marital prospects after psychosis. 1928 27

The admixture of different ancestral populations in America may have important implications for the risk for psychiatric disorders, as it appears to have for other medical disorders. The present study investigated the role of population admixture in risk for several psychiatric disorders in European-Americans (EAs) and African-Americans (AAs). This is a multisite study with 3,792 subjects recruited from across the United States, including 3,119 EAs and 673 AAs. These subjects included healthy controls and those with substance dependence (SD) [including alcohol dependence (AD), cocaine dependence, and opioid dependence], social phobia, affective disorders, and schizophrenia. In addition, DNA was included from 78 West Africans. The degree of admixture for each subject was estimated by analysis of a set of ancestry-informative genetic markers using the program STRUCTURE, and was compared between cases and controls. As noted previously, the degree of admixture in AAs was higher than EAs. In EAs, the degree of admixture (with African ancestry) was significantly lower in patients with SD (mainly AD) than controls (P = 0.009 for SD; P = 0.008 for AD). This finding suggests that population admixture may modulate risk for alcohol dependence. Population admixture might protect against alcohol dependence by increasing average heterozygosity and reducing the risk of deleterious recessive alleles. We cannot exclude the possibility that the results might have been influenced by selection bias due to the multisite nature of the study.
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PMID:Population admixture modulates risk for alcohol dependence. 1930 6

A research project entitled 'operation oasis' was implemented in West Bengal prisons by SEVAC, supported by the National Human Rights Commission of India for identification of the persons suffering from major psychiatric illnesses (ie, schizophrenia, psychosis not otherwise specified, mood disorder not otherwise specified) in prisons, making arrangements for their psychiatric treatment and rehabilitation and assessing the changes in them after intervention. Dum Dum Central Jail, Presidency Jail (female section), and Berhampore Central Jail were selected as the project fields. The prison inmates were screened through clinical examination and mental state examination. Among them who were found suffering from mental illness were brought under psychiatric and psychological treatment, rehabilitation and restoration. Their sociodemographical data were also collected on the basis of a structured information schedule developed by the SEVAC team. The patients were followed-up for three consecutive years (2001 to 2004). The global assessment of functioning scores of the patients recorded at the time of initiation and completion of project were compared. During the project implementation period, 3871 prison inmates (male 3527 + female 344) were screened and 10% (n = 401) were identified as suffering from major psychiatric illnesses, of which 64% (n = 258) were housed in the prisons for minor offences/stray cases and 90% (n = 363) were undertrials. The findings concluded with a global assessment of functioning score improvement with a statistical significance of p < 0.01 level (Z = 5.06) for the patients. This study shows that a qualitative change took place in the life situations of the mentally ill people who were brought under the purview of psychiatric treatment and rehabilitation.
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PMID:Persons with major psychiatric illness in prisons--a three years study. 1958 81

West Nile Virus (WNV) is a neurotropic flavivirus that can cause debilitating diseases, such as encephalitis, meningitis, or flaccid paralysis. We report the safety, pharmacokinetics, and immunogenicity of a recombinant humanized monoclonal antibody (MGAWN1) targeting the E protein of WNV in a phase 1 study, the first to be performed on humans. A single intravenous infusion of saline or of MGAWN1 at escalating doses (0.3, 1, 3, 10, or 30 mg/kg of body weight) was administered to 40 healthy volunteers (30 receiving MGAWN1; 10 receiving placebo). Subjects were evaluated on days 0, 1, 3, 7, 14, 21, 28, 42, 56, 91, 120, and 180 by clinical assessments, clinical laboratory studies, electrocardiograms (ECGs), and pharmacokinetic and immunogenicity assays. All 40 subjects tolerated the infusion of the study drug, and 39 subjects completed the study. One serious adverse event of schizophrenia occurred in the 0.3-mg/kg cohort. One grade 3 neutropenia occurred in the 3-mg/kg cohort. Six MGAWN1-treated subjects experienced 11 drug-related adverse events, including diarrhea (1 subject), chest discomfort (1), oral herpes (1), rhinitis (1), neutropenia (2), leukopenia (1), dizziness (1), headache (2), and somnolence (1). In the 30-mg/kg cohort, MGAWN1 had a half-life of 26.7 days and a maximum concentration in serum (C(max)) of 953 microg/ml. This study suggests that single infusions of MGAWN1 up to 30 mg/kg appear to be safe and well tolerated in healthy subjects. The C(max) of 953 microg/ml exceeds the target level in serum estimated from hamster studies by 28-fold and should provide excess WNV neutralizing activity and penetration into the brain and cerebrospinal fluid (CSF). Further evaluation of MGAWN1 for the treatment of West Nile virus infections is warranted.
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PMID:Safety and pharmacokinetics of single intravenous dose of MGAWN1, a novel monoclonal antibody to West Nile virus. 2035 Sep 45

Quality of life research in India on patients with schizophrenia is scarce. Quality of life interview (QOLI), a commonly used instrument in the West has not been used in a developing country like India. The aim was to assess convergence validity of QOLI (modified as per the Indian cultural background). 38 clinically stable outpatients with chronic schizophrenia (as per ICD-10) were administered QOLI- Brief version. Quality of Life Scale (QLS) and WHOQOL- Bref over two interviews the latter two scales having cross-cultural applicability. Significant correlations were obtained for QOLI with QLS and WHOQOL-Bref. It can be concluded that QOLI demonstrated convergent validity with both a disease-specific (QLS) and a generic (WHOQOL-Bref) scale, which have been previously used in the Indian setting. Hence, results support the applicability of QOLI in a different sociocultural setting.
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PMID:Convergent validity of quality of life interview (qoli) in an Indian setting: preliminary findings. 2120 56

The authors studied the prevalence of the human leukocyte antigen (HLA) Class I gene in 136 (85 male, 51 female) India-born schizophrenia patients residing in and around the Siliguri subdivision of West Bengal by the PCR-SSP method. The control group consisted of 150 age- and sex-matched healthy individuals from the same ethnic group as the patients. Increased frequency of HLA A*03 as well as decreased frequencies of HLA A*31 and HLA B*51, was noted. The study suggests the possible existence of a susceptibility locus for schizophrenia within the HLA region.
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PMID:Study of HLA Class I gene in Indian schizophrenic patients of Siliguri, West Bengal. 2145 56

Association of some neurotropic viruses like Borna Disease virus and Herpes virus with schizophrenia is better explained. However, the role of West Nile virus (WNV) infection in schizophrenia is not well documented. Therefore, this study was performed to investigate possible association between schizophrenia and presence of antibodies and WNV RNA in schizophrenic patients. For this, 200 blood samples from patients with schizophrenia and 200 from control groups were collected in Istanbul, Turkey. WNV RNA was not detected in any of the 200 patients and 200 controls analyzed by real-time RT-PCR. One hundred and twelve sera of schizophrenic patients and 162 of controls were analyzed for the presence of IgG antibodies to WNV by a commercial IgG-ELISA (Euroimmun, Germany). Antibodies to WNV were detected in 6 schizophrenic patients and 5 controls. ELISA positive patients had antipsychotic therapy. The difference between groups in terms of seropositivity to WNV was not statistically significant (p = 0.887, p = 0.148). Known symptoms of schizophrenia were observed in these patients, and interestingly majority had close contact to cats in the past and come from agricultural area of Turkey where potential area of mosquitoes and bird habitat. In conclusion, the results of this study show that antibodies to WNV in people do not seem to be associated with schizophrenia. However, detecting antibodies to WNV in schizophrenic patients suggests that WNV infection should be considered in endemic areas as it may play role in psychiatric diseases.
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PMID:Investigation of schizophrenic patients from Istanbul, Turkey for the presence of West Nile virus. 2172 13


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