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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This article summarizes a series of studies conducted by our group that examined the social perceptual deficits of schizophrenia. Research suggested that social perceptual deficits are more pronounced in patients with nonparanoid schizophrenia than comparison groups comprising normal controls or individuals with paranoid schizophrenia. The social perceptual deficits of schizophrenia were affected by the level of abstraction of cue descriptors; the level of emotional arousal engendered by the situation; the presence of extraneous, emotionally arousing stimuli; and the familiarity of the situation. These deficits were not found in standardization and cross-validation samples of normal controls, suggesting that these differential deficits represent a characteristic of the disorder rather than a psychometric confound. Social perceptual deficits in schizophrenia were significantly associated with verbal recall memory and relatively unrelated to visual vigilance. These latter findings were used in a study on rehabilitation of cue perception which showed that memory rehabilitation significantly improved cue perception whereas attention focusing strategies had no appreciable effects.
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PMID:The social perceptual deficits of schizophrenia. 946 Jan 1

This review examines the literature on neuropsychological differences between paranoid and nonparanoid schizophrenia subjects. Thirty-two studies related to intellectual functioning, attention, memory, language, visual-spatial, and motor functions are discussed. Subjects with paranoid schizophrenia did not demonstrate higher intellectual functioning than those with nonparanoid schizophrenia, and both groups performed similarly on tests of verbal ability and visual-spatial functions. Several studies suggest that the paranoid subtype is associated with higher performance on tests of executive functions, attention, memory, and motor skills. However, the findings are inconsistent. Methodological issues in the literature are examined, including varying degrees of participants' chronicity and severity of illness among studies, criteria for diagnostic group membership, medication effects, reliability and validity of the neuropsychological measures, and statistical power.
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PMID:A review of neuropsychological differences between paranoid and nonparanoid schizophrenia patients. 950 51

The authors analyze both the demographic situation in Russia during the past years and its perspective. A number of patients with paranoid schizophrenia and with schizophrenia on the whole (all forms of disease) was estimated for the period of the coming 15 years (till 2011 yr.). The level of the patients' detection in some Russian regions was estimated by means of comparison of the calculated number of the patients (according to tables of incidence) and actually known during the same period. The proportion of registered schizophrenic patients was up to 95.7% from calculated data in Moscow, while in other regions this index was not more than 50%. A low detection of the schizophrenic patients was explained by both specificity of the organization of psychiatric care in the regions, a shortage of psychiatrists as well as by other factors.
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PMID:[Main trends in the demographic development in Russia and dynamics of the rate of patients with schizophrenia]. 950 4

Seventy DSM-III schizophrenic patients were assessed for positive and negative symptoms using Andreasen's scales for the assessment of positive and negative symptoms (SANS and SAPS) on admission. The correlation structure of the items in the SANS and SAPS was explored in dimension and item levels by use of correlation plots through a distinct analytical method displaying the proximity matrix. The results revealed at least three major dimensions of symptoms delineated as Negative Symptoms, Disorganized Thoughts and Delusions and Hallucinations. The latter two dimensions were derived from the SAPS, while Negative Symptoms comprised most of the items in the SANS. Items in Disorganized Thoughts were more correlated to Negative Symptoms than to the other items in the SAPS. 'Loss of ego boundary' delusions and experience of auditory hallucinations appeared as two sub-clusters in the group of Delusions and Hallucinations. The relative independence of persecutory, grandiose, religious, somatic and reference delusions gives support to the concept that paranoid schizophrenia stands as a distinct clinical subtype of schizophrenia. The graphical method introduced here well expresses the information of correlation matrix and is useful for exploring inter-item or inter-cluster associations.
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PMID:Psychopathological dimensions in schizophrenia: a correlational approach to items of the SANS and SAPS. 954 Nov 48

EEG coherence provides a measure of functional correlations between two EEG signals. The present study was conducted to examine intrahemispheric EEG coherence at rest and during photic stimulation (PS) in 18 drug-naive patients with paranoid schizophrenia and 30 control subjects. Compared with the controls, the schizophrenic patients had significantly higher intrahemispheric coherence of the resting EEG for the delta band, although no significant group differences were found for other frequency bands. EEG analysis during PS showed that the patients also had significantly higher EEG coherence over the left posterior regions. In this study, we also examined the changes in intrahemispheric coherence from rest to the stimulus condition (i.e., PS-related coherence reactivity); the patients were found to show significantly smaller changes, with significant group differences being also confined to the posterior regions in the left hemisphere. These findings provide evidence that schizophrenic patients have abnormal EEG coherence in both resting and stimulus conditions and suggest more diffuse, undifferentiated functional organization within hemispheres. In addition, diminished coherence reactivity suggests a failure of PS-related functional reorganization in schizophrenia.
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PMID:Aberrant functional organization in schizophrenia: analysis of EEG coherence during rest and photic stimulation in drug-naive patients. 973 4

Several studies [5,6] on the prevalence of psychiatric disorders among migrants describe a higher rate of schizophrenic disorders. Other studies [2,3] as well as DSM-IV [1] point out that affective disorders with psychotic symptoms can be misdiagnosed as schizophrenic or schizoaffective disorders. We report on a patient admitted with the diagnosis of paranoid schizophrenia (ICD-10: F20.0), discussing differential diagnostic criteria and the problems of diagnosing along ICD-10 criteria.
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PMID:[Differential diagnosis of psychotic disorders in immigrants]. 973 50

The authors present the review of literature concerning schizophrenia, schizophrenia type and delusional disorders in patients with a lifetime diagnosis of anorexia nervosa (AN). The authors describe also 3 patients (2 cases of paranoid schizophrenia and 1 case of catatonic syndrome). The clinical features in all patients are discussed. In 1 patient the catatonic symptoms occurred within the context of AN, (perhaps due to metabolic disturbances) and in 2 other cases the psychotic features occurred after recovery from AN. The authors discuss the occurrence of psychotic features in AN, and the possible function of starvation and metabolic disturbances in their aetiology.
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PMID:[Schizophrenia, schizophrenia-like disorders and delusional disorders in patients with anorexia nervosa: literature review and report of 3 cases]. 973 79

Backward masking deficits have been put forward as potential psychological markers for vulnerability to schizophrenia. This study was conducted to investigate whether schizophrenic patients improve their performance on a backward masking task during a single test session. The ability of a degraded stimulus version of the masking task to act as a specific diagnostic marker for paranoid schizophrenia (versus affective disorder) was also investigated. The backward masking task was performed on 18 paranoid schizophrenic patients, 18 unipolar depressed patients, and 18 non-psychiatric controls. Paranoid schizophrenic patients were included because they tend to show normal performance with traditional masking protocols. Schizophrenic patients made significantly more detection errors compared to depressives and non-psychiatric controls where interstimulus intervals (ISIs) longer than 14 ms were used. Unlike depressed patients and non-psychiatric controls, schizophrenic patients showed no reduction in error rate during the entire period over which the backward masking task was performed. The constant error rate which was observed at an ISI of 114 ms suggests that schizophrenic patients cannot attenuate the disruption effect due to deflection of attention from the target to the mask. The backward masking deficit in schizophrenia appears to arise from a temporarily stable visual processing impairment in performance within a single test session.
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PMID:Backward masking in schizophrenia: time course of visual processing deficits during task performance. 978 47

Postmortem prefrontal cortices (PFC) (Brodmann's areas 10 and 46), temporal cortices (Brodmann's area 22), hippocampi, caudate nuclei, and cerebella of schizophrenia patients and their matched nonpsychiatric subjects were compared for reelin (RELN) mRNA and reelin (RELN) protein content. In all of the brain areas studied, RELN and its mRNA were significantly reduced (approximately 50%) in patients with schizophrenia; this decrease was similar in patients affected by undifferentiated or paranoid schizophrenia. To exclude possible artifacts caused by postmortem mRNA degradation, we measured the mRNAs in the same PFC extracts from gamma-aminobutyric acid (GABA)A receptors alpha1 and alpha5 and nicotinic acetylcholine receptor alpha7 subunits. Whereas the expression of the alpha7 nicotinic acetylcholine receptor subunit was normal, that of the alpha1 and alpha5 receptor subunits of GABAA was increased when schizophrenia was present. RELN mRNA was preferentially expressed in GABAergic interneurons of PFC, temporal cortex, hippocampus, and glutamatergic granule cells of cerebellum. A protein putatively functioning as an intracellular target for the signal-transduction cascade triggered by RELN protein released into the extracellular matrix is termed mouse disabled-1 (DAB1) and is expressed at comparable levels in the neuroplasm of the PFC and hippocampal pyramidal neurons, cerebellar Purkinje neurons of schizophrenia patients, and nonpsychiatric subjects; these three types of neurons do not express RELN protein. In the same samples of temporal cortex, we found a decrease in RELN protein of approximately 50% but no changes in DAB1 protein expression. We also observed a large (up to 70%) decrease of GAD67 but only a small decrease of GAD65 protein content. These findings are interpreted within a neurodevelopmental/vulnerability "two-hit" model for the etiology of schizophrenia.
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PMID:A decrease of reelin expression as a putative vulnerability factor in schizophrenia. 986 Oct 36

Amphetamine-induced psychosis is frequently associated with a chronic, high-dose, daily pattern of amphetamine exposure. In the present study we investigate the effects of prenatal exposure to amphetamine during the development of the central noradrenergic (NA) system in adult rats. Pregnant Wistar rats were given 4 mg/kg/day of d-amphetamine (AMPH), subcutaneously, from gestational day 8 to 21. No additional drug treatment was given to the animals until the beginning of the experiments, in adult, control and prenatally amphetamine treated rats. Since we study the electrophysiology and neurochemistry of the central NA system, we investigated the electric activity of locus coeruleus (LC) norepinephrine (NE) neurons and the levels of NE on prefrontal cortex. What we found, was a decreased number of spontaneously active cells in the LC nucleus with a lower pattern of discharge whereas, the basal levels of NE in the prefrontal cortex, was greatly increased. The increased cortical NE levels, observed in the present study may account for the proposed hyperactive NA system being responsible for some psychotic symptoms observed in paranoid schizophrenia. Besides, our results concerning the permanent alteration observed in the central NA system, in rats prenatally exposed to amphetamine, raise the possibility that this animal model may be useful to further study the neurobiologic alterations underlying certain clinical features involved in some psychosis such as schizophrenia.
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PMID:Permanent alteration of central noradrenergic system by prenatally administered amphetamine. 987 28


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