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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It is known that children of schizophrenic parents have an increased risk for becoming schizophrenic, but it has been extremely difficult to determine what features may exist in such children before they become manifestly ill that might provide a key for identifying vulnerability to subsequent disorder. This study was carried out to determine whether certain types of egocentric perception exist in the children of psychotic parents that might represent a clue to vulnerability. Sixty parent-child pairs were investigated as part of the University of Rochester (NY) Child and Family Study, using standardized diagnostic assessment procedures in the parents and several methods for evaluating egocentric perception in their offspring. Results showed that severity of psychotic symptoms in a parent related significantly to the degree of persistent age-inappropriate spatial egocentrism in his or her child. All of several diagnostic approaches used for parent classification were about equally valid in this regard, except for hospital diagnosis of schizophrenia, which did not correlate significantly with offspring egocentricity.
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PMID:Egocentrism in children of parents with a history of psychotic disorders. 42 May 41

L-Methionine had no behavioral effects in normal humans and failed to increase concentrations of S-adenosylmethionine (methyl donor) in human or rat blood, while increasing rat liver levels more than fivefold. Methionine or S-adenosylmethionine in very high doses had almost no effect on methylation of tritiated levodopa in rodent tissues; various "methyl acceptor" molecules, including nicotinamide, guanidineacetic acid, and estradiol similarly had little effect. In rabbit lung, methionine and S-adenosylmethionine not only failed to increase production of dimethyltryptamine, but actually decreased it, possibly due to end-product inhibition by S-adenosylhomocysteine, which also strongly inhibited methylation of dopa in rat. These results fail to support several predictions of the "methylation hypothesis" concerning the pathophysiology and potential treatment of idiopathic psychotic disorders and leave the consistent clinical worsening effects of methionine in schizophrenia unexplained.
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PMID:Methylation hypothesis. 42 May 48

Performed detailed neuropsychological evaluations with 25 recently hospitalized schizophrenics in whom systematic neurologic workups had failed to reveal CNS disease. Efforts were made to minimize possible effects of drug-induced extrapyramidal symptoms on test performance. Although the schizophrenics showed some neuropsychological impairment relative to 25 normals, their deficits were not as severe as those of patients known to have either acute or chronic brain disorders (N = 25). The diagnostic accuracy achieved by the tests supports their use in short-term treatment facilities when the differential diagnosis includes schizophrenia and brain disorder, especially acute brain disorder. Schizophrenics' neuropsychological impairment was more correlated with degree of EEG abnormality than with degree of psychosis, which suggests a possible organic basis for the deficits that they showed on testing.
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PMID:Neuropsychological impairment with schizophrenia vs. acute and chronic cerebral lesions. 42 30

The authors describe three patients with delusional unipolar depression whose delusional thinking worsened markedly following administration of tricyclic antidepressant drugs. The patients had met Research Diagnostic Criteria for major depressive episode and had no evidence of schizophrenia or mania. Since tricyclic antidepressants are known to exacerbate psychosis in schizophrenic patients, it is sometimes suggested that the exacerbation of psychotic thinking in depressed patients indicates schizophrenia. The authors suggest that such an exacerbation does not in itself indicate schizophrenia but may occur in patients with an affective disorder who are prone to depressive delusions. The authors discuss the use of antipsychotic medication in this patient group and present a neurochemical hypothesis to explain the interaction of the drug with the illness, which results in exacerbation of psychotic thinking.
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PMID:Exacerbation of psychosis by tricyclic antidepressants in delusional depression. 42 46

A psychiatric field-survey was conducted in three villages in West Bengal, India in order to correlate the prevalence of mental morbidity with the socio-economic status of the families. The sample was divided into four groups on the basis of religion or caste. Total morbidity had no statistically significant relationship with socio-economic status in any of the four groups. In the total sample it was directly related. Higher classes had significantly higher rates. Psychoses were not correlated with socio-economic status in any of the groups. Neuroses showed a significantly higher rate in the upper strata of two groups; in the other two groups the trend of prevalence was in the same direction. The four groups had significant differences in their rates of total morbidity. In all the groups females had a higher rate of mental morbidity. Psychoses, Neuroses and Depression were commoner in females and Schizophrenia was commoner in males.
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PMID:Socio-economic status and prevalence of mental disorders in certain rural communities in India. 43 27

Psychiatric disorders were investigated in 74 patients with drug-resistant temporal lobe epilepsy (complex partial epilepsy). In all cases unilateral anterior temporal lobectomy had been performed during the period 1960-69. At follow-up in 1970-71, 45 patients were free from seizures, and in a further group of 15 patients seizure frequency had been substantially reduced. There were four postoperative deaths. Six patients were psychiatrically normal and had no history of any such disorder. Behavioural disturbances were observed in 55 patients. Before operation 11 patients displayed schizophrenia-like psychoses, and nine others became psychotic during follow-up. Fourteen patients attempted suicide on one or more occasions. Half the patients had diminished sexual drive. Improvement in psychiatric status was clearly correlated with relief from seizures and, in those cases with only a few or no seizures after operation, led directly to social rehabilitation. The presence or absence of a psychiatric disorder was not useful as a criterion for or against surgery.
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PMID:Mental aspects of temporal lobe epilepsy. Follow-up of 74 patients after resection of a temporal lobe. 43 35

Encephalopathy (acute organic brain syndrome) superimposed on functional psychosis may be overlooked because the physician assumes that any exacerbation is due to fluctuation in the psychosis. Correct diagnosis requires a high index of suspicion and a firm knowledge of the signs of encephalopathy. A careful diagnostic approach permits the recognition of encephalopathy and separates it from functional disorders such as schizophrenia.
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PMID:Superimposed encephalopathy in the psychotic patient. 47 61

Evidence of lateralized hemispheric dysfunction in schizophrenia was previously found with a measure of visual evoked potential (VEP) wave-shape stability. The purpose of this study was to determine whether the VEP findings would extend to the auditory and somatosensory modalities. Measures of wave-shape stability were computed for auditory (AEP) and somatosensory (SEP) evoked potentials, recorded from one EOG and 14 scalp leads. Subjects were 74 unmedicated patients (49 schizophrenics, 25 nonpsychotics) and 27 nonpatients; two sets of age- and sex-matched comparison groups were formed. Main findings were: (i) Overtly psychotic schizophrenics exhibited lower than normal stability in left hemisphere AEPs (15-100 msec poststimulus). (ii) Both overtly psychotic and latent schizophrenics showed lower than normal wave-form stability, bilaterally, in the later epoch of AEPs (101-450 msec poststimulus). (iii) A subgroup of overt schizophrenics (other than chronic paranoid or chronic undifferentiated) had lower than normal stability in SEPs (15-100 msec) evoked by right median nerve stimuli and recorded from the right (ipsilateral) hemisphere. It was concluded that only the AEP results augment the previous VEP evidence indicating left hemisphere involvement in schizophrenic dysfunction.
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PMID:Somatosensory and auditory evoked potential studies of functional differences between the cerebral hemispheres in psychosis. 47 24

Psychotic and nonpsychotic psychiatric inpatients were tested on the Rorschach. "Reality-testing" was measured by four form-level scoring systems designed by Beck, Mayman, Becker, and Wilensky. The psychotic subjects were dichotomized on three diagnostic dimensions: schizophrenia, paranoia, and premorbid social adjustment. No significant differences were found for the Beck system. With the other systems, psychotics showed significantly poorer reality testing than nonpsychotics. No differences were found for the schizophrenic and paranoid dimensions. The Phillips premorbid adjustment score was negatively correlated with all four measures of "reality-testing." The conclusion drawn was that Rorschach measures of "reality testing" are associated with psychotic and poor premorbid functioning, but do not differentiate schizophrenic from nonschizophrenic psychotics or paranoid schizophrenics from nonparanoid schizophrenics.
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PMID:A comparison of Rorschach developmental level and form-level systems as indicators of psychosis. 48 Jan 7

In an attempt to demonstrate a valid boundary between schizophrenia and the affective psychoses, discriminant function analyses have been carried out with history, mental state and follow-up data in two populations of patients. A bimodal distribution of discriminant scores was obtained in one of them (a general psychotic sample of 128 patients), using a discriminant function derived from the same sample; but when the function was applied to the second population (a schizoaffective sample of 106 patients) the distribution was ambiguous. Functions derived from the schizoaffective sample produced highly skewed distributions of discriminant scores in the general psychotic sample. Kraepelin's hypothesis that the functional psychoses consist of two distinct disease entities receives some support from our findings, but there is still no compelling evidence that the universe of psychotic patients falls naturally into these two groups.
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PMID:The distinction between the affective psychoses and schizophrenia. 48 50


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