Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Reports of chronic bromine intoxication have been few in recent years: possibly this condition is now being under diagnosed. A case of drug psychosis due to chronic bromide ingestion and incorrectly diagnosed as schizophrenia is reported. Specific pharmacokinetic aspects of bromide and bromo-ureide are outlined and the clinical features of chronic bromine poisoning are considered with reference to possible diagnostic errors. There are clear indications for diagnostic testing and for appropriate treatment.
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PMID:[Bromism--an overlooked disease picture]. 382 20

Although the etiology of drug psychosis or schizophrenia is still unknown, molecular and biochemical researches have recently made significant advances in the search for the candidate genes of these disorders. Among such studies are animal models of drug psychosis or schizophrenia such as amphetamine-induced behavioral sensitization or phencyclidine-treated animals. In this review, it is suggested that amphetamine or phencyclidine change the gene expressions related to not only neurotransmitter systems such as dopamine or glutamic acid, transcription factors, cell proliferation, apoptosis, cell adhesion, but also the synapse. These alterable gene expressions may lead to the discovery of candidate genes of drug psychosis or schizophrenia and thus to novel antipsychotics.
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PMID:Analysis of overall gene expression induced by amphetamine and phencyclidine: novel targets for the treatment of drug psychosis and schizophrenia. 1181 56