Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ten patients suffering from chronic psychiatric disorder with violence were admitted for stereotactic multitarget limbic leucotomy. Eight of them were schizophrenia, one was paranoid, and one was mania. In operation, thermococagulative lesions were made bilaterally in the amygdala, the anterior cingulate region and the innominate region. The criteria of the patients selected for the operation, the operative procedure and evaluation of the results are introduced. Five patients achieved significant improvement and three patients showed some improvement after operation. The complications included, temporary mild paraplegia (in four cases) and sphincter disturbances (in five cases) in the first two weeks postoperation. The choice of targets and possible causes of complications are discussed.
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PMID:[A preliminary report on stereotactic multi-target limbic leucotomy]. 268 47

Guan's acupuncture technique is a kind of special acupuncture methods developed and improved by GUAN Zheng-zhai. It has unique curative effects on hysterical paralysis, schizophrenia, madness, epilepsy and traumatic paraplegia, etc. This acupuncture technique has the characteristics of "deep" "transparent" "moving" and "sensing". The acupoints selection is different from that of twelve meridian acupoints. The deep insertion of acupuncture needles is applied at acupoints located in the wrist joint, ankle joint and below, while the penetration needling method is applied at acupoints located in the area which has relatively thick muscles, and where yin-meridian and yang-meridian are symmetric with each other. The horizontal and deep connection of acupoints and the adjustment effect of qi-blood and yin-yang are emphasized during treatment.
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PMID:[Guan's acupuncture technique and the rules of acupoints selection on leg]. 3094 39

GluD2 receptor belongs to the orphan delta family of glutamate receptor ion channels. These receptors play key roles in synaptogenesis and synaptic plasticity and are associated with multiple neuronal disorders like schizophrenia, autism spectrum disorder, cerebellar ataxia, intellectual disability, paraplegia, retinal dystrophy, etc. Despite the importance of these receptors in CNS, insights into full-length GluD2 receptor structure is missing till-date. Here we report cryo-electron microscopy structure of the rat GluD2 receptor in the presence of calcium ions and the ligand 7-chlorokynurenic acid, elucidating its 3D architecture. The structure reveals a non-swapped architecture at the extracellular amino-terminal (ATD), and ligand-binding domain (LBD) interface similar to that observed in GluD1; however, the organization and arrangement of the ATD and LBD domains in GluD2 are unique. While our results demonstrate that non-swapped architecture is conserved in the delta receptor family, they also highlight the differences that exist between the two member receptors; GluD1 and GluD2.
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PMID:The architecture of GluD2 ionotropic delta glutamate receptor elucidated by cryo-EM. 3251 55