Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hereditary spastic paraparesis (HSP) is characterized by progressive spasticity and weakness of the legs with or without additional abnormalities. Reports of psychiatric disorders in patients with HSP are limited to mood disturbances rather than to psychosis. We had noted significant psychotic illness in several patients recruited to a survey of HSP in Ireland and therefore set about examining the frequency and nature of psychosis in our patients with HSP. Cases with HSP and psychotic illness were identified from a nationwide epidemiological and clinical study. Psychiatric case notes were reviewed and Operational Diagnostic Criteria Checklist (OPCRIT) applied. Six patients from four families with HSP had evidence of psychosis in addition to paraparesis. OPCRIT diagnoses were 'narrow schizophrenia' (n = 2), 'broad schizophrenia' (n = 2) and 'schizo-affective/manic disorder' (n = 2). Patients were from families with Kjellin's syndrome and SPG4-HSP but not other kindreds and psychosis was not evident in family members without HSP. We found a higher than expected rate of psychosis in the Irish HSP population. Two groups of HSP patients may have increased risk of developing psychosis: those with Kjellin's syndrome and those with SPG4-HSP.
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PMID:Hereditary spastic paraparesis and psychosis. 1687 99

Relatively little is known about the violent victimization experiences of people with major mental disorders. Moreover, to date, no studies have examined recurring violent victimization experiences of people with major mental disorders. Using a risk heterogeneity framework commonly used in the study of recurring victimization, the current study examines the extent of recurring victimization among people with Diagnostic and Statistical Manual of Mental Disorders (DSM) Axis I mental disorders and trajectories of recurring violent victimization (n = 262), across four waves of data collected during a 1-year longitudinal study. Multilevel logistic regression analyses tested disorder, time, and time by disorder cross-level interactions predicting recurring victimization. Results suggest that recurring violent victimization is not uncommon among mentally disordered victims of violence, with 64% of victims experiencing a recurring victimization at a later point in time. However, trajectories of recurring violent victimization are not uniform across types of mental illness. Indeed, individuals diagnosed with a substance abuse disorder or major depression show significantly declining trajectories across the follow-up period whereas individuals diagnosed with a manic disorder or a schizophrenia spectrum disorder have flat trajectories of recurring violent victimization across the study period. Results of tests for cross-level interactions between disorder type and time demonstrate that individuals with a major depression or substance abuse/dependence diagnosis are significantly different from those with a schizophrenia spectrum diagnosis in their trajectories of recurring victimization.
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PMID:Trajectories of recurring victimization among people with major mental disorders. 2425 64


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