Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Abnormal intestinal absorption has been suggested as an aetiological factor in schizophrenia. A procedure for investigating intestinal permeability was carried out in a group of chronic psychiatric in-patients. A proportion of the subjects studied showed abnormal intestinal permeability which could not be attributed to established bowel disease. Patients who were receiving neuroleptic but not anticholinergic drugs were those most often showing abnormal intestinal permeability. This work is at an early stage of development but preliminary findings suggest that further investigations should be carried out to establish the circumstances in which changes in intestinal permeability may be associated with mental illness.
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PMID:Abnormal intestinal permeability. An aetiological factor in chronic psychiatric disorders? 365 40

A comprehensive overview of the clinical aspects of lithium therapy is presented. Emphasis is placed on recent developments regarding the clinical uses of Li2CO3 in non-psychiatric conditions. The established efficacy of the drug in the treatment and prophylaxis of mania and bipolar affective disorders is noted, and the evidence supporting the use of lithium salts as a prophylactic agent in unipolar depression, aggressive behavior, schizophrenic disorders and organic brain dysfunction is discussed. The use of lithium carbonate in various disorders of movement and in certain extrapyramidal diseases is summarized, as are the results of its trials in alcoholism and drug abuse. In addition, uses of Li2CO3 in asthma, thyroid diseases, granulocytopenia, headache, bowel disease, anesthesiology, cardiology, and sleep disorders are summarized. The data suggests the potential effectiveness of Li2CO3 in a variety of clinical conditions other than those for which it is classically indicated, provided more detailed double-blind studies are performed.
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PMID:Clinical uses of lithium salts. 641 55

Ulcerative colitis and Lesniovsky-Crohn's disease are classified as idiopathic diseases. The study highlighted the role of the immune system, environmental and behavioral factors. Lists of infectious agents relevant to the development of ulcerative colitis and morbus Crohni, indicating the importance of the NOD2/CARD15 mutations. Quoted the results of studies on the effect of stress and immune response in patients with diagnosed ulcerative colitis. Discusses the implications arising from somatic mental patients, having regard to the causes of social isolation of patients and their rejection of social support. The study examined the results of research on quality of life of patients treated for ulcerative colitis and Crohn's disease. Stressed the importance of depression and anxiety in the development of idiopathic inflammatory bowel diseases. The results of studies showing the treatment of depression and anxiety as predictors of development idiopathic intestinal diseases were cited. The possibility of increased incidence of schizophrenia was excluded among people living with inflammatory nonspecific bowel disease.
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PMID:[Anxiety and depression in ulcerative colitis and Lesniovsky-Crohn's disease]. 2081 77

The Annual Inhaled Drug Delivery Conference organized by Management Forum was held in London, UK, 9-10 November 2010. The meeting focused on a range of disease therapies from the pulmonary indications routinely treated with inhaled medicines (asthma, cystic firbrosis and chronic obstructive pulmonary disease) to novel applications of the inhalation route to treat systemic diseases (irritable bowel disease, schizophrenia, migraine, diabetes and obesity).
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PMID:Annual Inhaled Drug Delivery Conference. 2283 40

The isolation of heat-stable enterotoxin (STa) from Escherichia coli and cholera toxin from Vibrio cholerae has increased our knowledge of specific mechanisms of action that could be used as pharmacological tools to understand the guanylyl cyclase-C and the adenylyl cyclase enzymatic systems. These discoveries have also been instrumental in increasing our understanding of the basic mechanisms that control the electrolyte and water balance in the gut, kidney, and urinary tracts under normal conditions and in disease. Herein, we review the evolution of genes of the guanylin family and STa genes from bacteria to fish and mammals. We also describe new developments and perspectives regarding these novel bacterial compounds and peptide hormones that act in electrolyte and water balance. The available data point toward new therapeutic perspectives for pathological features such as functional gastrointestinal disorders associated with constipation, colorectal cancer, cystic fibrosis, asthma, hypertension, gastrointestinal barrier function damage associated with enteropathy, enteric infection, malnutrition, satiety, food preferences, obesity, metabolic syndrome, and effects on behavior and brain disorders such as attention deficit, hyperactivity disorder, and schizophrenia.
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PMID:From Escherichia coli heat-stable enterotoxin to mammalian endogenous guanylin hormones. 2465 26