Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In order to obtain further evidence of possible psychopathology, the Minnesota Multiphasic Personality Inventory (MMPI) was administered to 25 patients (pts) who had the controversial EEG pattern of rhythmic midtemporal discharges--(RMTD) psychomotor variant. The pts were divided into a retrospective and prospective group, the former consisting of only a minority (36%) of pts who had previously agreed to cooperate and the latter consisting of every pt (100%) showing the pattern in a 3-year period. The scores of all RMTD pts were abnormal (approximately 2 SD above the normal mean) for hypochondriasis, schizophrenia, depression, and hysteria and were classified as Abnormal on Rule 1 on the Goldberg sequential diagnostic system. Patients with intermediate or many bursts of this pattern were also classified as Abnormal, scored higher on every clinical scale, significantly so on five of the clinical scales and were significantly different with regard to the number of clinical scale scores at or over the T value of 70 as well as 80. The MMPI profile of RMTD pts is similar to those with definite temporal lobe epilepsy but different from pts with general medical disorders.
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PMID:Evidence for psychopathology in patients with rhythmic midtemporal discharges. 651 12

Investigated the possible use of the MMPI-168 as a screening instrument for identifying individuals (N = 27) with DSM III diagnosed borderline personality disorder. Using previously reported percentile norms for bright young college graduates as a reference, borderline patients as a group fell above the 98th percentile on the F, Hypochondriasis, Depression, Hysteria, Psychopathic Deviate, Psychasthenia and Schizophrenia scales, as well as the general psychopathology scale (PSY). Additionally, the borderline sample's mean score on the Paranoia scale was above the 95th percentile, and the mean Social Introversion scale was above the 90th percentile. Almost equally distinguishing was the finding that the mean K scale score for the borderline sample fell as low as the 8th percentile for the normative college sample. These results demonstrate that the MMPI-168 response pattern of borderline patients was clearly distinguishable from the great majority of college graduates.
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PMID:Screening for borderline personality disorders with the MMPI-168. 663 May 46

Adolescents aged 12-15 years, randomly selected from a psychiatric outpatient clinic, psychiatric consultation service, and general pediatric outpatient clinic, were given a complete psychiatric evaluation and structured diagnostic interview. Of 121 subjects studied, 100 satisfied Rutter and associates' criteria for a childhood psychiatric disorder. When these subjects were rediagnosed according to Feighner and associates' research diagnostic criteria (similar to DSM-III criteria), 52 fulfilled the criteria for an adult disorder. Diagnoses included antisocial personality, hysteria, schizophrenia, depression, mental retardation, anxiety neurosis, and undiagnosed psychiatric illness. There was a correlation between diagnosis according to Rutter and associates' criteria and adult diagnosis.
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PMID:Adult psychiatric disorders in psychiatrically ill young adolescents. 665 Jun 88

The epidemiological and clinical profile of Chronic Post-Traumatic Headache (CPTH) has been studied in 57 out of 130 consecutive patients hospitalized, following closed head injuries, at the Institute of Neurosurgery of the University of Milan. The incidence of CPTH has been 44%. Age of the patients ranged between 4 and 69 years. Clinical pictures included closed head injuries of different degree of severity: mild, moderate and severe. Time of onset, headache frequency, character, intensity, duration and associated symptoms showed a great degree of variability. However, chronic muscle contraction headache was the commonest clinical syndrome followed by migraine. Moderate correlations have been found between the severity of CPTH disturbance of consciousness, following the head trauma, and positive findings at CT scan. Moreover the comparison of personality profiles (MMPI) of CPTH (n=26) with a post-traumatic control group, without headache (n=17) showed higher scores on hypocondriasis, depression, hysteria and schizophrenia scales only in the severe CPTH group. Age of the patients, duration of unconsciousness, neurological deficits, course length and pending litigation or compensations were unrelated to the occurrence and outcome of CPTH. These findings suggest the importance of both physical and psychological determinants (social or emotional maladjustment) in the pathogenesis of CPTH.
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PMID:Chronic post-traumatic headache: clinical, psychopathological features and outcome determinants. 666 50

The question of the relationship between motor behaviour and psychopathology has been of concern to clinicians for many years. This question appears in the history of diseases as different from each other as general paralysis, hysteria, schizophrenia and mental retardation. The questions raised were the source of the development of a symptomatology of motor behaviours--the domain of which is not muscular potential or praxic abilities (action capacities) as much as their actual use in observed action (action "realization"). This symptomatology implies an interpersonal dimension, which translates itself into bodily postures, gestures, changes of position, movements from one place to another and the manner in which the patient accomplishes actions. An analysis of their organization and their diachronic unfolding enables one to grasp and understand more effectively certain psychic states, and to act on them. This clinical approach leads to greater specificity in the area of geriatric psychiatry. Here, diagnosis is not an entity which encompasses the totality of the symptoms which identify a disease, but as knowledge necessary to engage in a therapeutic program. Such an approach takes into account the disease, the patient and his environment, and thereby validates an original approach to the study of motor behaviours in geriatric psychiatry.
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PMID:[Psychomotor activity and diagnosis in geriatric psychiatry]. 666 21

EEG/closed-circuit television long-term monitoring was used as a definitive diagnostic tool to identify and characterize 25 patients with pseudoepileptic seizures and a similar group of subjects with epilepsy, confirming the value of the procedure. The groups did not differ with respect to intelligence, neuropsychological impairment, or incidence of potential etiological factors for seizures. Scores on the Minnesota Multiphasic Personality Inventory (MMPI) and the Hypochondriasis, Hysteria, and Schizophrenia Scales were significantly higher for the pseudoepileptic group than for the other subjects. As a whole, the former patients exhibited an MMPI profile pattern frequently seen in the conversion form of hysteria. A set of three rules derived from the MMPI profiles was used to classify the patients correctly in 80-90% of cases. As evaluated by the Washington Psychosocial Seizure Inventory, psychosocial problems of patients with pseudoepileptic seizures were more severe in certain areas, and appeared to reflect early family background problems and inappropriate management of their disorders.
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PMID:Intensive EEG monitoring and psychological studies of patients with pseudoepileptic seizures. 669 85

The mean creatine phosphokinase level of 41 psychotic patients was significantly higher than that of 30 nonpsychotic psychiatric patients, as were their MMPI paranoia and schizophrenia scores. Their creatine phosphokinase level was negatively correlated with hysteria and psychopathic deviance.
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PMID:Creatine phosphokinase, the MMPI, and psychosis. 670 42

Patients with multiple personalities are excellent hypnotic subjects, a capability demonstrated both clinically and on a standard hypnotizability test. They tend to experience a plethora of symptoms associated with anxiety states, hysteria, obsessional neuroses, phobic states, depression and mania, schizophrenia, alcoholism, sociopathy, and hyperactivity--although there are exceptions to this profile. Both males and females suffer from this disability, and an MMPI profile for female multiples is described.
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PMID:A symptom profile of patients with multiple personalities, including MMPI results. 670 17

The total sample size for the study of intrapsychic variables was 252 (152 non-drug users and 100 life-time users including 69 current users). Using a multiphasic personality questionnaire, the Eysenck personality inventory and an orientation questionnaire, the authors found that high orientation, extraversion, anxiety and psychopathic deviate scores were associated with a relative risk of drug use. No significant difference is reported between the mean scores of users and non-users on mania, paranoia, depression, schizophrenia, hysteria and neuroticism.
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PMID:Relative risk of adolescent drug abuse: Part II. Intrapsychic variables. 691 3

Temporomandibular joint dysfunction is multifactorial in etiology. In many patients, psychological factors contribute to the development of symptoms. This is a retrospective study of 25 patients who had temporomandibular joint dysfunction and facial pain as an early sign of significant primary psychopathology. The diagnoses were: acute depression, manic-depressive illness, hysteria, and schizophrenia. Diagnosis of the underlying psychopathology and recognition of its role in the etiology of temporomandibular joint symptoms permitted more effective treatment.
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PMID:Temporomandibular joint dysfunction: an occasional manifestation of serious psychopathology. 694 52


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