Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Case histories of two family members with multiple exostosis and schizophrenia are presented. There are no previous reports of such an association. The computerized axial tomography scan revealed signs of hydrocephalus in one patient and substantial enlargement of lateral brain ventricles in the other. The mutual occurrence of all three clinical findings (multiple exostosis, ventricular brain enlargement and psychosis) in two family members may suggest a subgroup of patients who manifest schizophrenic symptomatology.
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PMID:Multiple exostosis, brain ventricular enlargement and schizophrenia. 265 86

A dysfunction of the choroid plexus or the tela choroidae is suggested as the cause of ventricular enlargement in normal pressure communicating hydrocephalus and in some schizophrenic syndromes. In communicating hydrocephalus, the function of the tela choroidae could be impaired by infectious or inflammatory processes; while in schizophrenia a physiologic disorder of cerebrospinal fluid production due to a melatonin deficiency may result in dilated ventricles. Paradoxically, in both disorders, there is decreased production of cerebrospinal fluid.
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PMID:The pathophysiology of enlarged ventricles in normal pressure communicating hydrocephalus and schizophrenia: a possible therapeutic role for melatonin. 361 4

Three patients with hydrocephalus and aqueduct stenosis are described, who also have schizophrenia defined according to strict diagnostic criteria. There are no previous reports of such an association.
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PMID:Aqueduct stenosis and schizophrenia. 660 88

In two adults, both schizophrenia and hydrocephalus were associated with aqueduct stenosis. The prevalence is argued to be above chance, and may contribute to the neurodevelopmental hypothesis of the causality of schizophrenia.
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PMID:Schizophrenic psychosis and associated aqueduct stenosis. 792 23

Mentally handicapped individuals were involved in some way in 64 (17.7%) of the total of 362 medico-legal autopsy cases during the past 13 years. Among these 64 cases, 32 were suicides committed by mentally handicapped persons (18 males and 14 females). The most common method of suicide was drowning (65.6%). Five cases were homicides suddenly and unexpectedly committed by mentally handicapped persons. In four of the five cases, the victim was a member of the assailant's family; this was considered to be a characteristic of homicides committed by mentally handicapped persons. On the other hand, there was only one case in which a mentally handicapped person was victimized, that of a 34-year-old female with schizophrenia who was strangled by her mother. In 19 cases, infanticide was committed by mentally handicapped mothers ranging in age from 17 to 40 years old; approximately 80% of the infanticide victims were infants of less than 6 months, and this was the age range most at risk of victims. There were two cases involving either double suicide or murder followed by suicide; in one case, the 45-year-old mother of a mentally handicapped 18-year-old son with congenital hydrocephalus set fire to her own house, and both perished in the fire, and in the other, a 65-year-old schizophrenic female fatally stabbed her neighbor, a 68-year-old female, and then she also cut herself fatally. There were three cases in which mentally handicapped individuals died due to freezing, and one in which an epileptic died suddenly due to status epilepticus. In order to prevent these tragic events, at first, it is necessary to much better understand the circumstances of the mentally handicapped individuals and their families without prejudices against them. The authors propose that a more comprehensive psychiatric medical care including the following systems should be established in Japan: 1) Day care for the mentally handicapped person, especially after the discharge as well as during admission, and support for their relatives, 2) Therapeutic drug monitoring to assess the effective level of psychotropic drugs and to suppress the side effects in the patients receiving the psychotropic drugs for a long time.
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PMID:Retrospective investigation of medico-legal autopsy cases involving mentally handicapped individuals. 858 92

Retinoic acid, the morphogenic derivative of vitamin A, has been shown to alter patterns of neurulation and to regulate the expression of many genes involved in central nervous system development. Retinoid toxicity can result in craniofacial, limb, digit, heart and urogenital abnormalities. Hydrocephalus, due to increased ventricular size and/or decreased size of the hind- or forebrain, occurs frequently. Comparison of the frequency and type of congenital anomalies in extended pedigrees of 12 Ashkenazi probands with schizophrenia and seven normal Ashkenazi control probands indicates that relatives of the schizophrenic probands present a gamut of both minor and major congenital anomalies similar to, but less severe than, those caused by retinoid excess or deficiency, and at a frequency significantly greater than in control pedigrees. Within schizophrenic pedigrees, those diagnosed with schizophrenia spectrum illnesses are more likely to present such anomalies than are non-spectrum members. Retinoic acid receptors are present in all parts of the cranial region and delivery of retinoids is exquisitely controlled throughout embryonic and fetal development. Alterations in the functioning of the retinoid cascade may have profound implications for neurodevelopmental disorders like schizophrenia.
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PMID:Congenital anomalies in relatives of schizophrenic probands may indicate a retinoid pathology. 878 14

This paper presents 6 patients with catatonia and subthalamic mesencephalic tumors with hydrocephalus involving the third and the lateral ventricles. This anatomic and psychiatric anomaly is investigated on the basis of personal observations and a review of the literature. These cases allow an interesting parallel to be traced between neurological clinical signs and psychiatric signs. Various anatomic and physiological models are discussed which emphasize specialized neuronal circuits (somewhat similar to those involved in Parkinson's disease) and certain specific neurotransmitters such as dopamine, together with the reactivity of these circuits to intracranial pressure variations. Once more, clinical and laboratory data on schizophrenia concur to suggest that organic etiology is the causal factor in a known psychiatric pathology.
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PMID:Schizophreniform catatonia on 6 cases secondary to hydrocephalus with subthalamic mesencephalic tumor associated with hypodopaminergia. 890 36

Neurotrophin-3 (NT-3) may have a potential role in the pathogenesis of schizophrenia, given evidence of abnormal neurodevelopment in schizophrenia, as well as a potential association of an NT-3 gene polymorphism with schizophrenia. Cerebrospinal fluid NT-3 protein was assayed using an enzyme-linked immunosorbent assay in five patients with schizophrenia and 49 patients with medical illness. None of the patients with schizophrenia had detectable levels of NT-3 (above 4.7 pg/ml). Eleven samples from 10 different patients with medical or neurological illness had detectable levels of NT-3, associated with surgery for hydrocephalus or central nervous system infection.
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PMID:Neurotrophin-3 levels in the cerebrospinal fluid of patients with schizophrenia or medical illness. 946 44

Free radicals and antioxidants may play a role in the etiology and pathogenesis of some central nervous diseases. The brain tissue is relatively insufficiently protected by antioxidants against the free radical induced damage. The brain situation may be reflected by the cerebrospinal fluid examination, which has not enough attention. It seems, that from this point of view subarachnoical hemorrhagy, meningitis, hydrocephalus, Alzheimer's, Parkinson's and Huntington's diseases, multiple sclerosis and probably schizophrenia should receive a special attention.
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PMID:[Free radicals and antioxidants in cerebrospinal fluid in central nervous system diseases]. 1240 89

Cerebral ventricular size in humans varies significantly. Abnormal enlargement of the ventricles has been associated with schizophrenia, and hydrocephalus can lead to serious cognitive and motor deficiencies in humans and animals. In this study, we mapped quantitative trait loci (QTLs) modulating cerebroventricular size in mice. We hypothesized that genes underlying hydrocephalus might also modulate normal variation in ventricular size. By using digital images of mouse brain sections and stereological techniques, we estimated the volume of the combined lateral and third ventricles, as well as the volume of the entire brain, in 228 AXB and BXA recombinant inbred mice and their parent strains (A/J and C57BL/6J). Ventricle size, expressed as percentage of brain volume, is a heritable trait (h(2) = 0.32). We detected a major QTL controlling variance in volume on chromosome (Chr) 8 near the markers D8Mit94 and D8Mit189. We also detected a strong epistatic interaction affecting ventricular volume between loci on Chr 4 (near D4Mit237 and D4Mit214) and on Chr 7 (D7Mit178 and D7Mit191). These three QTLs, labeled Vent8a, Vent4b, and Vent7c, are close to genes that have been previously implicated in hydrocephalus.
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PMID:Quantitative trait loci modulate ventricular size in the mouse brain. 1274 74


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