Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. In the last ten years basic research on the mechanism of action of opiates has led to the clearcut demonstration of the existence of opiate receptors--possibly several slightly different kinds--in the nervous system. 2. A number of endogenous ligands also called endorphins or enkephalins for these receptors have been discovered that proved to be peptides with opiate-like pharmacological activity and were shown to be localized in strategic neuronal pathways in the brain, spinal cord and pituitary gland. 3. Clinical researchers are beginning to explore the possible role of these opiate-like peptides in a variety of clinical situations such as: pain and analgesia, tolerance and dependence, reinforcement mechanisms, memory processes and learning, and mental illness such as schizophrenia. 4. The discovery of biologically active opioid and other peptides coexisting with more traditional neurotransmitters in the same neurons may lead to a reevaluation of our fundamental notions of how the brain operates. This is viewed as a major advancement not only to our understanding of the theoretical basis of drug actions but also as a first step towards the development of new, practically useful methods for treating the clinical problems associated with drug abuse.
 ...
PMID:Opiate receptors and endogenous opiates: panorama of opiate research. 612 96

A comprehensive overview of the clinical aspects of lithium therapy is presented. Emphasis is placed on recent developments regarding the clinical uses of Li2CO3 in non-psychiatric conditions. The established efficacy of the drug in the treatment and prophylaxis of mania and bipolar affective disorders is noted, and the evidence supporting the use of lithium salts as a prophylactic agent in unipolar depression, aggressive behavior, schizophrenic disorders and organic brain dysfunction is discussed. The use of lithium carbonate in various disorders of movement and in certain extrapyramidal diseases is summarized, as are the results of its trials in alcoholism and drug abuse. In addition, uses of Li2CO3 in asthma, thyroid diseases, granulocytopenia, headache, bowel disease, anesthesiology, cardiology, and sleep disorders are summarized. The data suggests the potential effectiveness of Li2CO3 in a variety of clinical conditions other than those for which it is classically indicated, provided more detailed double-blind studies are performed.
 ...
PMID:Clinical uses of lithium salts. 641 55

Violence to self and to others on a locked, acute-care unit is reported for a three-year period. Drug abuse correlated strongly with both types of violence. Self-violence appeared to be a more predictable event due to its diagnostic specificity, history of prior violence and timing of the episodes. Assaults occurred more randomly demonstrating only a mild association with schizophrenia, but not with other psychotic disorders.
 ...
PMID:Self and other directed violence on a closed acute-care ward. 653 72

Anorexia nervosa is a disease of increasing frequency with serious medical and psychological consequences. The presentation is one of significant weight loss. The initial assessment of such a patient must differentiate between an underlying systemic medical illness and an eating disorder. This paper will review the more common medical conditions causing weight loss and their distinguishing characteristics, including malignancy, inflammatory bowel disease, infections and metabolic disorders. Once an organic disease is ruled out, anorexia nervosa must then be differentiated from other eating disorders such as bulimia or other psychological diseases such as depression, schizophrenia, drug abuse, conduct disorders, and anxiety reactions. The pathogenesis of anorexia nervosa includes complex societal, family, and individual factors which require evaluation in the treatment process.
 ...
PMID:Differential diagnosis and pathogenesis of anorexia nervosa. 659 95

Historical accounts emphasize a high rate of mental morbidity in the Faroe Islands compared with Denmark. As prerequisites for a comparative investigation are now present, we have compared a 10-year period of first admission rates in both areas. We found a lower rate for the Faroes generally, in particular for women, for the age group 30-64, and also for the majority of diagnostic groups. The group manic-depressive psychosis come closest to Danish conditions, followed by reactive psychosis and alcohol and drug abuse. The greatest difference was found for the groups personal disorders, neuroses, and schizophrenia.
 ...
PMID:First admissions for psychiatric disorders. A comparison between the Faroe Islands and Denmark. 661 21

Primary alcoholics may display symptoms of affective or psychotic disorders, while mentally ill patients may develop persistent alcohol-related problems. The author discusses the importance of distinguishing alcoholic psychosis from schizophrenia and alcohol-induced confusion from organic brain syndrome. He then outlines the diagnosis and treatment of other alcohol-induced conditions such as alcoholic dementia, antisocial behavior, and drug abuse. After stressing that primary alcoholism can mimic almost any psychiatric disorder, and secondary alcohol abuse can exacerbate any psychiatric symptoms, the author asserts that physicians should routinely include substance abuse as part of the differential diagnosis of psychiatric patients.
 ...
PMID:Alcoholism and other psychiatric disorders. 664 46

The authors applied DSM-III criteria to 268 consecutive Chinese inpatients. Nearly a quarter had affective disorder, a third had schizophrenia, and, except for one patient, none had alcoholism or drug abuse. The authors discuss the factors influencing hospitalization in China.
 ...
PMID:The frequency of major psychiatric disorder in Chinese inpatients. 671 92

Hospital records of 72 drug abusers with psychoses (DAP) were analyzed to clarify the relationship between drug abuse and psychosis. Comparison groups included schizophrenics and atypical schizophrenics without drug abuse and drug abusers without psychoses (DA). Compared with DAP in whom psychoses lasted less than six months before admission (DAP-short), drug abusers with psychoses of a longer duration (DAP-long) had more symptoms, more premorbid personality disorders, and greater familial risks of schizophrenia and affective disorder. The DAP-long group resembled atypical schizophrenia for clinical features and family history, whereas the DAP-short group resembled DA for some clinical features and family history. The results indicate that there are several subgroups of DAP. The importance of clinical features and family history in identifying subgroups of DAP was stressed.
 ...
PMID:Subtypes of drug abuse with psychosis. Demographic characteristics, clinical features, and family history. 706 28

Self-inflicted mutilation of the eyes is an uncommon but fairly distinct entity. Patients are typically young men; they often have criminal records and histories of drug abuse. Underlying schizophrenia is a common feature. The patients frequently suffer from castration fears, oedipal conflicts, repressed homosexual impulses, severe guilt, and a need for punishment. We treated two patients with this disorder. The first, a 26-year-old prison inmate convicted of murdering his grandfather, cut his eyes with a razor blade. He had previously attempted to commit suicide, suffered from delusions, and experienced auditory hallucinations. Surgical repair of his injuries improved his visual acuity to R.E.: 6/15 (20/50) and L.E.: 6/30 (20/100). The second patient, a 24-year-old inmate of a mental institution, had previously undergone a lensectomy for a hypermature cataract induced by a self-inflicted lye burn in his left eye. One year later, he was treated for lacerations of his right eye and partial amputation of his tongue. In the year between admissions, he had enucleated his left eye. Visual acuity in his remaining eye was no light perception, so no surgery was performed.
 ...
PMID:Self-inflicted ocular mutilation. 723 50

It has been suggested that changes in brain 5-hydroxytryptamine3 receptor function may contribute to some behavior disorders, such as anxiety, schizophrenia and drug abuse. We are using the whole-cell version of the patch-clamp technique to study the function of 5-hydroxytryptamine3 channels in neurons freshly dissociated from rat nodose ganglion. In these cells, 5-hydroxytryptamine elicits an inward current over the concentration range of 0.25-100 microM (EC50 = 2.62 microM) by activating 5-hydroxytryptamine3 receptors. The muscarinic cholinergic antagonist atropine reduced the amplitude of 5-hydroxytryptamine activated inward current in a concentration-dependent manner. Other muscarinic antagonists, scopolamine, dexetimide, the M1 muscarinic receptor antagonist pirenzepine, the M2 receptor antagonist methoctramine and the M3 receptor antagonist 4-DAMP methiodide also inhibited 5-hydroxytryptamine-induced inward current. Atropine did not appear to change the reversal potential of this current. In the presence of 5 microM atropine, the concentration-response curve for 5-hydroxytryptamine current was shifted to the right in a parallel fashion. The EC50 value for 5-hydroxytryptamine was increased from 2.62 to 8.76 microM. Schild plots of increasing atropine and 5-hydroxytryptamine concentrations revealed a pA2 value of 5.74 for atropine (apparent KD = 1.8 microM). These observations suggest that atropine competitively antagonizes the activation of a receptor for the neurotransmitter serotonin, a novel action of muscarinic antagonists in the nervous system. This effect of atropine may contribute to the clinical symptoms seen in severe atropine intoxication.
 ...
PMID:The effect of atropine on the activation of 5-hydroxytryptamine3 channels in rat nodose ganglion neurons. 753 5


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>