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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During an uncontrolled trial 46 depressed patients (39 endogenous depressions, 5 schizoaffective psychoses and 2 paranoic schizophrenics with depressive syndromes) were treated for 43 days on the average with 3 X 100 mg 1-[3-(10,11-dihydro-5H-dibenz[b,f]-azepin-5-yl)-propyl]-4-piperidino-piperidine-4-carboxamide-dihydrochloride-monohydrate (carpipramine) daily. The clinical impression of the improvement and the results of the Hamilton-Scale for depressions (19 patients, 24 items) showed a clear antidepressive effect of carpipramine. During a double-blind trial 14 patients were treated with carpipramine and 16 with doxepine for 30 days. Most patients suffered from endogenous depressions with paranoic symptoms or from schizophrenia with depressive syndromes. Statistical analysis of the Hamilton-Scale for depressions and the AMP-System showed the antidepressive and antipsychotic effect of carpipramine. Analysis of covariance showed no significant difference between carpipramine and doxepine. Altogether we treated 60 depressive patients with carpipramine. 26 patients improved very well and 11 moderately, that means 37 patients out of 60 reacted positively to therapy with carpipramine. One endogenous depression and a schizoaffective psychosis changed into a manic phase. A provocation of schizophrenic symptoms was not noticed. Carpipramine was very well tolerated and can be classified as a non-sedative antidepressant with an antipsychotic effect.
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PMID:[Activity profile of carpipramine. Results of an open trial and a double-blind trial versus doxepin]. 1 52

This review surveys the therapeutic efficacy of tricyclic antidepressants and monoamine oxidase inhibitors in schizophrenic patients. In general, the use of these drugs alone was found not to be warranted in schizophrenia, except perhaps in the so-called pseudoneurotic subgroup. In most cases, combinations of antidepressants and phenothiazines were not more beneficial than phenothiazines alone. In particular, the conditions of agitated patients and patients with histories of social deviance dating back to childhood were often made worse by the addition of an antidepressant. However, when the patients who demonstrated symptoms of clinical depression other than anergia were isolated from several of these studies, it was found that they constituted a subgroup that was often benefited by use of these combinations. Favorable and unfavorable clinical response patterns are discussed, and recommendations for future research are outlined.
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PMID:Use of antidepressant drugs in schizophrenia. 3 Apr 29

The responsibility of the folate deficiency in some neuropsychiatric disorders is recent knowledge. The role of the folate on the nervous system is not yet well definite, but the action on the metabolism of the amino-acids, on the purine and the pyrimidine synthesis and on the metabolism of the catecholamins are certainly essential. The neuropsychiatric diseases secondary to the folate deficiency are numerous: dementia, schizophrenia like syndromes, insomnia, irritability, forgetfulness, endogenous depression, organic psychosis, pueperal psychosis, peripheral neuropathy, myelopathy (spinal cord syndrome and/or pyramidal tract damage), restless legs syndrome. Clinically the diagnosis may be difficult with sub acute combined degenration secondary to the pernicious anaemia, and the dosage of the folate (in serum, in red-cells and in cerebrospinal fluid) is necessary. The congenital defects in the uptake or utilization of the folate are associated with neuropsychiatric disturbances. The treatment is easy and safe if the vitamin B12 deficiency is eliminated and if employed with caution in epileptic patients because folate can induced seizures.
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PMID:[Folate and the nervous system (author's transl)]. 22 16

The granting of abortions according to the psychiatric indication (PI) in West Germany is discussed. The PI is sharply differentiated from the emergency indication, which is of a social nature. These 2 indications merge in the case of psycho-social considerations. Possible psychological complications of the abortion operation itself should be considered in deciding whether an abortion should be granted, and a waiting period of at least a day should be allowed for both patient and physician before a definite decision is made. The indication for sterilization in conjunction with the abortion operation and the possibility of continuing therapy for those whose abortions are not granted are additional considerations or the decision on the suitability of the PI for a particular patient. The evaluation of suicidal tendencies is important for the psychological evaluation of abortion seekers. In general, cases of endogenous depression do not constitute a indication for abortion, while reactive depression may lead to depressive decompensation in a patient who has an unwanted pregnancy. The prognosis in such cases is especially hard to determine in younger patients. Character neuroses and alcoholism or similar diseases complicate the psychiatrical determination. In cases of schizophrenia and oligophrenia with good prognoses, abortion is not usually indicated. Most applications for abortion which are denied under the PI are of social character and belong under the emergency indication, e.g. serious physical illness of the mother, other handicapped family members, young, unwed mothers. These principles are illustrated with sample cases.
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PMID:[Psychiatric indications for pregnancy interruption]. 35 Aug 3

In the introduction the heuristic basis of neuroendocrinology and the relationship to current concepts in biological psychiatry is analyzed. Various neuroendocrinological approaches to the study of depressive and schizophrenic disorders are then exemplified by the discussion of selected papers. In contrast to studies in schizophrenic patients abnormal findings have been found, by several research approaches, in endogenous-depressive patients. These findings are consistent with the hypothesis of a disfunction of biogenic amines in endogenous depression; however, considering the neuroendocrinological methodology at hand these findings are not conclusive.
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PMID:[Neuroendocrinology in depression and schizophrenia (author's transl)]. 58 89

One hundred and fifty-two cases of changes in diagnosis of 'schizophrenia', 'endogenous depression' and 'psychopathia' in the course of illness, are statistically analyzed in regard to tendency of changes of diagnosis, sex, symptomatics and syndromatics, age of onset and duration of cycles. The changes of diagnosis show a clear tendency in favour of the diagnosis of 'schizophrenia' as opposed to 'psychopathia'. Among the cases with changed diagnoses, women are significantly over-represented. On the level of symptomatics, few significant changes of symptom frequencies can be found. More information can be obtained in the analysis on syndromatics: four out of six groups show significant changes in the intensity of syndromes; on the basis of similarities in syndrome profiles, derived from materials which are diagnostically homogeneous, the actual diagnostic components can be evaluated. The analysis of the age of onset shows significant differences of means corresponding to the expectations of the hypothetic diagnostic components. Regarding duration of cycles, significant differences of means between the groups are not to be found.
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PMID:[Investigations on the change of diagnosis in the course of illness in cases with initial respectively final diagnosis 'schizophrenia', 'endogenous depression' or 'psychopathia' (author's transl)]. 70 52

The breathing rate and PCO2 in end-tidal air have been studied in controls and in patients with endogenous depression (retarded and non-retarded), with neurotic depression, and with schizophrenia. It has been shown that breathing rate goes up and PCO2 down in non-retarded and neurotic depression. Schizophrenia gives more anomalous results. The fact is emphasized that such changes must lead to alterations in pH and other variables. Studies showing some small chemical differences between these clinical entities and control subjects might therefore be explained by these findings.
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PMID:Respiratory ventilation and carbon dioxide levels in syndromes of depression. 99 Jun 60

From a sample of 1,005 patients admitted to the Psychiatric Hospital in Aarhus for the first time during the period 1950-1959 and diagnosed as suffering from manic-depressive psychosis or endogenous depression (affective psychoses), a subsample of 104 manic-depressive patients with anancastic symptoms in the history was selected. The 104 probands were individually matched with 104 non-anancastic probands with affective psychoses. The study was designed as a follow-up study, and the patients who were still living were seen personally. In the search for factors which could be used to distinguish affective psychoses with anancastic symptoms from affective psychoses without these traits, the incidence of a number of psychopathological features was evaluated based on the case histories and the information given by the patients at the follow-up. There was no difference as far as atypical, schizophrenia-like symptoms were concerned between the anancastic probands and the controls. Manic and hypomanic features were more frequent among the controls, corresponding to a greater number of bipolar psychoses among them. At the same time, the controls showed a significant preponderance of decidedly psychotic symptoms such as disturbances of consciousness, delusions and delusion-like ideas and hallucinations. Furthermore, retardation was more frequent among the controls. There was no difference in the suicidal behaviour of the two groups. Symptoms which were more often met among the anancastic depressives were: anxiety, agitation, diurnal variation of mood and early awakening. Seasonal variation in symptomatology was also more frequent among the anancastic probands. The same held true for depersonalization. The anancastic probands showed a significant preponderance of anancastic premorbid personality features. A positive correlation was found between the number of anancastic personality features and the following symptoms: agitation, anxiety, diurnal fluctuation, seasonal variation, hypochondriacal attitude and depersonalization. On the other hand, objective retardation or flight of ideas showed a significant negative correlation. The pattern of the anancastic symptoms was rather uniform; aggressive obsessions, mostly in the form of suicidal and homicidal obsessions, were present in more than two thirds of the cases. The anancastic depressions were often less severe than non-anancastic depressions in that the latter were more often complicated by decidedly psychotic symptoms. It is possible to interpret the symptomatology of anancastic depressions as a pathoplastic influence of the anancastic personality, but it cannot be excluded that some of the symptoms like anxiety and agitation are linked to the presence of anancastic symptoms as such.
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PMID:The psychopathology of anancastic endogenous depression. 119 73

During the fiscal year 1 April 1972 to 31 March 1973, 22,210 ECT treatments in 3,438 series were given in Denmark (6-46 treatments per series). Indications for treatment were: endogenous depression, acute delirium, mania, hysterical psychosis, reactive depression and schizophrenia. Unilateral ECT was used in more than half of the departments concerned. Two treatments were given weekly. The types of apparatus and anaesthesia techniques used are described. One death, which had questionable relation to the ECT, was reported, and other complications were few and mild. The advantages of ECT compared to tricyclic antidepressants are described, including the higher percentage of remissions or improvements in the treatment of endogenous depressions (about 80 per cent for ECT compared to about 60 per cent for tricyclic antidepressants). Little risk was found in out-patient administration of ECT. With present techniques and unilateral placement of electrodes out-patient ECT may be recommended for wider use than before.
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PMID:Electroconvulsive therapy in Denmark. 125 87

Long before the era of heart surgery began, "cardiac psychoses" were known and described. They do not differ at all from postoperative psychoses after heart-surgery. On the other hand heart-surgery carries a far higher incidence of psychiatric complications than general surgery (general surgery 0,1--1,0%; heart surgery 10--60%). There is no reason to believe that the intensive care unit plays a decisive role in the origin of postoperative cardiac psychoses. Among 150 patients there were 60=40%, who did not show any psychiatric symptoms after surgery. These were exposed to the same environment of the intensive care unit as were the patients who developped symptoms. There were however correlations of statistical significance between "cardiac psychoses" and 1. an occurrence of endogenous psychoses in the family with first degree relatives or in the life history of the patient himself, 2 higher grade of severity of heart disease, 3. extra corporal circulation, 4. higher age, 5. male sex. Postoperative cardiac psychoses are mainly of the type of exogenous psychoses (akuter exogener Reaktionstyp Bonhoeffer). There is no doubt that psychological, reactive and environmental factors do play a certain role too. This is shown by the character of delusions and hallucinations which frequently reflect the postoperative situation. Persecutory delusions with the fear of being killed and ideas and fears of severe body mutilation are the most common motives. Similar motives are frequently observed in postoperative dreams. The manifestations of mental disease in the family or personal history of the patient is considered a significant presupposition of developing a cardiac psychosis of the type of endogenous depression, acute delirium or with schizophrenia like delusions.
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PMID:[Mental and neurological disorders associated with heart operations. Pre- and postoperative studies]. 126 55


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