Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Amplitude-interval factor analysis was made to study the EEG in young patients with atypical ++sub-depressive states (n-15) and depressive states (n-43) defined in the literature as "asthenic juvenile deficiency". It has been discovered that patients suffering from sluggish schizophrenia with prominent asthenic disorders differ from healthy test subjects, patients suffering from cyclothymia and those suffering from sluggish schizophrenia without well-defined asthenic symptomatology in significantly higher values of EEG factor related to the index, regularity and frequency of low-amplitude beta-activity as well as in the reduced values of the other EEG factor connected with the mean period of alpha-waves and with the theta-index. Based on the psychophysiological testing of structurally similar EEG factors, carried out earlier on healthy test subjects, the data obtained may be treated as reflection of the neurodynamic unbalance common to asthenic disorders in sluggish schizophrenia, which lies in abundance processes of cortical excitation and deficit of inhibitory processes of the active selective character. The intensity of depressive symptomatology correlated with relative deceleration of alpha-activity.
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PMID:[Specificity of electroencephalographic correlations of asthenic disorders in atypical juvenile asthenic-depressive conditions]. 196 5

Based on a ++clinico-statistical analysis of patients (n-159) with cyclothymia and schizophrenia with predominant affective symptomatology who fell ill in childhood and were followed up for 5 to 18 years the main tendencies of the disease course and different patterns of the personality dynamics were discovered, correlating with a number of the premorbid characteristics and the structure of the first attack. The mathematic treatment using the Boolean model enabled one to obtain a prognostic model which may form the basis for the expert system to objectively evaluate, specify and accelerate the process of individual forecasting in the endogenous affective syndromes in childhood. The author provides evidence for relativity of the alternative importance of the clinical signs whose genuine prognostic weight only becomes known in diverse combinations with the other signs.
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PMID:[Problems of clinical prognosis in endogenous diseases with predominant affective disorders in childhood]. 217 24

It is becoming increasingly recognized that one third to one half of children diagnosed as having attention deficit/hyperactivity disorder (ADHD) continue to exhibit symptoms of the disorder into adulthood. The nature of the clinical picture is not well understood by a substantial number of clinicians. The purpose of this study is to report on the demographic and clinical profile of 56 adults, age 19 to 65 years (48 men, eight women) who present with adult ADHD and meet DSM-III-R criteria for the disorder. Patients underwent a diagnostic work-up consisting of medical and psychiatric evaluation, a structured interview Schedule for Affective Disorders and Schizophrenia-Lifetime Version [SADS-L]), the Symptoms Checklist Revised (SCL-9OR), Conners Attention Deficit Disorder With Hyperactivity (ADDH) scale, structured interview of ADDH, the Global Assessment of Functioning Scale (GAF), and, when available, information from parents was obtained. Ninety-one percent of our sample met the Utah Criteria for adult ADHD. The majority of the sample had additional DSM-III-R diagnoses and only seven had ADHD diagnosis alone. Fifty-three percent of the sample met the criteria for generalized anxiety disorder, 34% alcohol abuse or dependence, 30% drug abuse, 25% dysthymic disorder, and 25% cyclothymic disorder. These findings were similar to those reported in the literature.
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PMID:A clinical and demographic profile of a sample of adults with attention deficit hyperactivity disorder, residual state. 222

Investigated were 55 patients with slow-progredient schizophrenia and cyclothymia aged 17 to 25 with the syndrome of vaso-autonomic dystonia (VAD) accompanying their mental disorder. VAD was found in 80% of the depressive cases, hypomaniac syndromes and psychopath-like (residual) states. Each of these disorders correlated with a distinct type of VAD. In a majority of the cases VAD manifested after several years of mental disease. The study provides grounds for combined psychotropic and rational psychotherapy with an early social rehabilitating assistance. The study substantiated the necessity of psychiatric services aimed at specialized psychiatric aid to these patients in the general out-patient clinic network.
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PMID:[Autonomic vascular asthenia as a component of the psycho- autonomic syndrome in slowly progressing schizophrenia and cyclothymic disorder in young patients]. 258 4

A total of 90 patients were investigated in the general practice out-patient clinics. The patients had not been earlier studied by a psychiatrist and had unclear forms of endogenous diseases and phobic disorders: 70 patients with slow progredient schizophrenia, 20 with cyclothymia. Despite the phobic manifestations of slow progredient schizophrenia and cyclothymia being identical on the phenomenological level, their structure and time course were different. Favorable++ and unfavorable clinico-psychopathological prognostic signs were determined for each of the diseases. The principles of therapeutic and rehabilitation tactics are discussed with special reference to the patients with slow progredient schizophrenia and cyclothymia with phobic disorders in primary health care units. Out-patient group was compared to the patients of dispensary departments.
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PMID:[Slowly-progressing schizophrenia and cyclothymic disorder with phobic manifestations in patients under a general practitioner's care]. 278 25

On the basis of clinico-epidemiological, clinico-dynamic and clinico-catamnestic study of 184 patients with schizoaffective variants of schizophrenia (cyclothymia-like, affective-paranoid, hallucinatory-delirious, and with catatonic symptomatology) the authors come to the conclusion on the relative homogeneity of this cohort of patients and on the considerably frequent favourable outcomes of this disease. The variants of the disease and structure of remissions of each of the clinical variants have been compared. Assessment of inter-attack clinical characteristics and the degree of social and occupational adaptation has made it possible to divide the patients into 3 groups differing by adaptational parameters. The results obtained may be used in the development of the system of rehabilitative measures in any of the aforesaid variants of schizophrenia.
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PMID:[Comparative clinical, social and work characteristics of patients with schizoaffective variants of schizophrenia]. 336 2

Forty-two patients with different types of functional cardiac arrhythmias were examined. Clinico-psychological examination revealed such general and relatively independent of the personality type features as conservatism, predisposition to anxiety reactions, hypochondriac readiness, symptomatic lability, poor self confidence in relation to interpersonal interrelations, poorly expressed ability to dominate with a tendency toward submission. Neurotic reactions and phases were a predominant feature in accentuated (n = 20) and psychopathic persons (n = 10). Slowly progressive schizophrenia and cyclothymia were diagnosed in 8 and 4 cases respectively. Treatment of functional cardiac arrhythmias with lexotan yielded good response in 50% of cases. In cases when lexotan alone failed to be effective, the use of this drug in combination with antiarrhythmic drugs effected good results in 61.8% of the patients.
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PMID:[Premorbid characteristics and nature of the mental disorders in patients with neurocirculatory dystonia and heart rhythm disorders (clinico-psychological research)]. 341 41

Slowly progressive schizophrenia with subclinical affective attacks in adolescence is characterized by undoubtful differences in the premorbid characteristics of patients, clinical picture and peculiarities of the course of the endogenic process. Different variants of the course are related to structurally and phenomenologically different variants of affective attacks. The more similar is the course of cyclothymia-like schizophrenia to protracted non-remission one, the more atypical are affective attacks (adynamic depressions and nonproductive hypomania); the more paroxysmal is the course, the more marked and diverse is the clinical picture of depression (dysphoric attacks) and the more typical are hypomanias. Patients with cyclothymia-like schizophrenia, besides therapy, are in need of the earliest possible rehabilitative treatment aimed at the continuation of education under easier conditions which expedites post-attack readaptation and improves social prognosis.
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PMID:[Characteristics of the course of cyclothymia-like schizophrenia in puberty]. 381 11

The reliability of French psychiatrists using DSM-III axis I disorders was studied using videotaped semi-structured diagnostic interviews, 136 psychiatrists with different levels of clinical experience classified 11 cases into six preselected diagnostic categories: Schizophrenia, Major Depressive Episode, Dysthymic Disorder, Cyclothymic Disorder, Other Psychiatric Diagnosis, No Present Psychiatric Diagnosis. A modified Kappa coefficient for multiple observers was used to calculate agreement and thereby estimate reliability. We obtained an overall Kappa of 0.55 for six categories, and when the Dysthymic and Cyclothymic Disorders were combined into one class, i.e. other specific affective disorders, the Kappa value increased to 0.64. The Kappa value for individual categories was best for Schizophrenia and Major Depressive Episode, and poor for Dysthymic and Cyclothymic Disorders. Clinical experience or prior knowledge of DSM-III criteria did not have a significant effect on reliability.
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PMID:Diagnostic reliability among French psychiatrists using DSM-III criteria. 396 99

Eighty-six patients with endogenous depression (cyclothymia, manic-depressive psychosis and schizophrenia) were treated by sleep deprivation. The efficacy of this treatment with regard to the structure of the depressive syndrome, the course of the attack and nosological nature is discussed. The author also considers the frequency, sequence and effectiveness of sessions of sleep deprivation in both hospital and outpatient settings. Series of total sleep deprivation were shown to be highly effective in cyclothymia and manic-depressive psychosis with melancholic and anesthetic depression, including cases with a protracted course.
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PMID:[Treatment of endogenous depressions by sleep deprivation]. 400 48


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