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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Kraepelin (1896) and Bleuler (1916) were convinced that schizophrenia has an anatomical basis. Evidence is provided now by visualization methods made in vivo and stereometric methods used in neuropathology. Schizophrenia is associated with enlargement of the lateral and the third ventricle, widening of the sulci between gyri of the cerebral cortex, a decline of the weight of the brain, volume of the cerebral cortex and central gray matter. Histological examination reveals reduction of the parahippocampal gyrus thickness, changes in the hippocampus are controversial. Numerical atrophy of neurons was found in the mediodorsal nucleus of the thalamus, amygdaloid nucleus, prefrontal cortex, impaired pattern of neuronal modules were found in the g.cinguli. Some anatomical changes correlate with differences revealed by neuropsychiatric examination, positron emission tomography and examination of evoked potentials. Schizophrenia can be at least in some instances the consequence of developmental disorder of the brain. The problem of continuity of schizophrenia and affective psychoses is discussed.
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PMID:[Structural changes in the brain in schizophrenia and affective psychoses]. 147 6

Schizophrenia may be described as a disease where speech, bodily language and social responsiveness are obvious expressions of a deteriorated ability to interact with the surroundings in a precise and relevant way. The lack of precision and relevance pertains to perception and recall as well as communication and action. The deficient potential for activation of the prefrontal cerebral cortex is a neurobiological correlate to the lesion of precise and relevant planning and expression. Impairment of formal thought and language in schizophrenia are suggested to result from a developmental disorder pertaining to language and concept formation (apperception). In reactive psychoses with dissociative disturbances of consciousness there is an inefficient capacity for adapting to external reality; thus relevant conscious planning and interaction with the outside world are impaired. Clinically a distractibility of a tematic nature ensues. Except for catastrophic events, psychotic reactions cannot be predicted from analysis of the actual experience--neither concerning the external nor the internal aspects of conscious awareness. Sometimes, however, previous events relating to the formation of the self may add explanatory value to the analysis of reactive psychosis. In some cases biological predisposition is the decisive determinant. The normal discrimination between sense-perception and imagination has a counterpart in the dichotomy of awareness of the outside world versus awareness of the self. The following are examples of psychotic experience where the normal ability for dichotomic discrimination may be damaged: Illusions of affect, hallucinations, Schneider's first rank symptoms, "Anwesenheit" and consciousness of time.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Consciousness functions in psychoses. Concepts, empirism and hypotheses]. 202 42

Infantile autism is a developmental disability characterized by onset of disturbances in social and language development before the age of 30 months. It must be distinguished from several disorders, including mental retardation and schizophrenia. Most evidence supports an organic basis for the syndrome. Treatment consists of training in language and communication skills, behavioral modification and, occasionally, chemotherapy. Supportive counseling and education for parents are vital to treatment. The prognosis for achieving a life of complete independence is poor.
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PMID:Infantile autism. 371 67

Possible associations between professional experience with mentally retarded people and diagnostic overshadowing were evaluated. In a 3 X 2 factorial experiment, psychologists at state developmental disabilities facilities (high-experience group), psychologists at state mental health facilities (moderate-experience group), and clinical graduate students (low-experience group) rated a case history of a person with schizophrenia on 11 scales of psychopathology. For approximately half of the subjects within each group, the client was mentally retarded in addition to schizophrenic; for the remaining subjects, the client had average intelligence. Professional experience was associated with diagnostic ratings but not with overshadowing. We concluded that diagnostic overshadowing is unrelated to a broad range of professional experience with retarded people.
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PMID:Diagnostic overshadowing and professional experience with mentally retarded persons. 682 17

A theoretical model of the etiology of schizophrenia, the schizophrenia spectrum, and normal development is proposed. This model is based upon replicated research. A selected review of the literature on the etiology of schizophrenia indicated that schizophrenia may be a developmental disorder of the quality of attachment interacting with the development of the reticulothalamocortical system, beginning in the earliest months of life. A genotype, phenocopy, and stress are specified, based upon replicated research results. We hypothesize that schizophrenia results from a continuing malforming transaction, beginning at birth, between a temperament genotype of a sensitive, easily aroused to high peaks of arousal baby and an environmental stress of an unempathic/insensitive, physically rejecting, noncontingent mother. This results in a classical conditioning paradigm wherein people become an aversive stimulus for an anxiously/avoidant attached infant. This anxious/avoidant response may have permanent biochemical and structural effects. It is also hypothesized that the same genotype interacting with an empathic, sensitive, physically affectionate, contingent mother may also account for artistically or musically creative superphrenics.
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PMID:A model integrating risk variables involved in the development of the schizophrenia spectrum. 731 Mar 85

Recent prospective studies indicate that schizophrenia manifests itself in behavioural abnormalities much earlier than was previously thought, supporting the view that schizophrenia is a developmental disorder.
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PMID:Schizophrenia. When neurons go astray. 762 43

Descriptions of various psychotic symptoms in children began to appear in the psychiatric literature at about the same time as descriptions of psychotic symptoms in adults. For example, Kraepelin estimated that at least 3.5 percent of his cases of dementia praecox had onsets before age 10. The construct of "childhood schizophrenia" initially emerged from attempts to classify a broad range of psychotic children. By the late 1940s and 1950s, the diagnosis of "childhood schizophrenia" was given to many disturbed children who today would be considered to have infantile autism and other developmental disabilities. In the early 1970s infantile autism and its variants was differentiated from schizophrenia of childhood onset. These changes were incorporated in DSM-III, which returned to the practice before 1930 of diagnosing schizophrenia in children using the same criteria as for adults, with minor allowances for differences in the manifestations of these symptoms during childhood. The studies presented in this issue of Schizophrenia Bulletin use DSM-III, DSM-III-R, or ICD-9 criteria for schizophrenia.
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PMID:Childhood-onset schizophrenia: editors' introduction. 770 Dec 70

The association between developmental defects of the corpus callosum and major psychiatric disturbance is discussed with a review of published cases. Seven new cases are presented, of which four had clear psychotic symptoms, two receiving a diagnosis of schizophrenia. Of the remainder, one had a developmental disorder affecting social interaction and speech which could be classed as Asperger's syndrome, one had a personality disorder with depressive and conversion symptoms, and the last was an adolescent boy with severe behavioural problems. The difficulties in determining the precise relevance of the callosal anomalies to these clinical manifestations are discussed especially since the prevalence of such anomalies in the population is uncertain.
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PMID:Severe psychiatric disturbance and abnormalities of the corpus callosum: review and case series. 827 Sep 44

Data were collected from 838 women over age 50 who have either a child with a developmental disability or a child with schizophrenia. Lawton et al.'s (1991) parallel channel hypothesis, which suggests that positive and negative aspects of mental health have differential predictors, was tested. Results indicate that positive caregiving appraisals were predicted by quality of the mother-child relationship, while negative caregiving appraisals were predicted by the amount of help mother provided to her child, mother's health, child's behaviors, and positive appraisals. Positive well-being was predicted by mother's health, positive appraisals, and negative appraisals, while negative well-being was predicted by mother's health, child's behaviors, and negative appraisals. Hence, the data support the usefulness of the hypothesized model.
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PMID:Mental health of aging women with children who are chronically disabled: examination of a two-factor model. 893 28

Among 136 adults with mental illness and mental retardation who were consecutively treated at a developmental disabilities clinic, 25 reported that they currently smoked cigarettes. Among those with mild and borderline retardation, smoking rates were 30 and 37 percent, respectively. Smokers were significantly more likely than nonsmokers to drink alcohol, use other drugs, and be sexually active. Multiple regression analysis found that a mild or borderline level of retardation and a diagnosis of schizophrenia were significant predictors of smoking. Mentally retarded persons with mental illness are at risk of tobacco-related disease and may benefit from prevention and smoking cessation interventions.
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PMID:Cigarette smoking among patients with mental retardation and mental illness. 921 9


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