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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study explored the symptoms of self-injurious behaviour (SIB) in a consecutive sample of 54 mostly female psychiatric inpatients. The phenomenological analysis presented SIB as quite a uniform syndrome that starts latest in early adulthood, is often committed impulsively, is used in the function of releasing tension and occurs in patients with eating and psychoactive substance use but also schizophrenic disorders. The quality of mood preceding SIB was best characterized as dysphoria and was qualitatively not different from patients' longstanding affective traits. Two subgroups were differentiated, those with borderline personality disorder and those without; there was some evidence that patients with borderline personality disorder present a quite homogeneous core group of SIB, whereas others show a higher variety of psychopathological features. The hypothesis is proposed that poor affect regulation is the underlying psychopathological dimension.
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PMID:Self-injurious behaviour. Psychopathological and nosological characteristics in subtypes of self-injurers. 775 89

Accurate diagnosis and a clear management approach are the most important considerations in caring for behaviorally disordered emergency department patients. Treating behavioral emergencies often precedes an accurate diagnosis. A useful approach is differentiating emergencies that need nonpharmacological intervention, minimal pharmacological intervention, or maximal pharmacological intervention. Conditions that require nonpharmacological interventions include suicidal state, homicidal state, self-neglect state, abuse state, and conditions primarily requiring an organic workup. Behavioral emergencies usually requiring minimal pharmacological intervention include adjustment disorder, acute grief, rape and assault, and borderline personality disorder. Behavioral emergencies requiring maximal pharmacological intervention include assault, agitated psychosis, exacerbation of bipolar disorder, exacerbation of schizophrenia, brief reactive psychosis, delirium, dementia, substance withdrawal, and substance intoxication accompanied by violent behavior.
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PMID:Management of behavioral emergencies. 775 34

Retrospective chart review was used to compare the demographic characteristics and psychiatric diagnoses of 150 consecutive female patients seen in psychiatric consultation in the emergency service at a Veterans Affairs medical center between 1987 and 1991 with those of two groups of 150 male patients matched by age or psychiatric diagnosis. Compared with the men, the women were younger and more likely to be divorced, to complain of anxiety or psychotic symptoms, and to have a diagnosis of a depressive disorder or borderline personality disorder. Men were more likely to have a diagnosis of schizophrenia or antisocial personality disorder.
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PMID:Characteristics of male and female veterans who use VA psychiatric emergency services. 779 18

This article overviews the development of the borderline personality disorder construct. In the past 25 years, the borderline personality diagnosis has grown remarkably in clinical usage even as its construct has undergone dramatic shifts in the process. It originated as a type of intrapsychic personality organization that reflected psychoanalytic observations and the hope for long-term curative therapies. It was transformed by descriptive observations into a syndrome whose boundaries with first schizophrenia and then affective disorders became the subject of intense study. More recently, it is recognized as a specific type of personality disorder that communicates substantial information about pathogenesis and that helps guide clinical planning and prognostication. The context dependency of the borderline patient's presentation explains why the diagnosis can often elude recognition.
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PMID:Building structure for the borderline construct. 801 Jan 46

The published and some unpublished studies of the genetic of borderline conditions are reviewed. It appears that the DSM-III-R borderline personality disorder is not genetically transmitted. The evidence for the genetic transmission of schizotypal personality disorder also appears weak. An examination of the 2 personality disorders reveals multidimensionality and heterogeneity. The borderline personality disorder seems to consist of 2 syndromes, an impulsive borderline and an empty borderline syndrome. The schizotypal personality disorder consists of 3 syndromes, one affect-constricted/eccentric, one pseudo-psychotic and one paranoiac isolated syndrome. The impulsive borderline, the affect-constricted/eccentric and the pseudo-psychotic syndromes seem slightly genetically influenced. The affect-constricted/eccentric syndrome appears to be genetically related to schizophrenia. No other Axis I disorders are related to borderline conditions.
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PMID:Genetics in borderline conditions. 801 Jan 47

Although the field is young, studies pertinent to genetic hypotheses have accumulated for several personality disorders. Genetic links to personality disorders from the domains of normal personality and Axis I disorders are reviewed. Evidence of a link to schizophrenia is clearest for schizotypal and less conclusive for paranoid and schizoid personality disorders. A genetic association between borderline personality disorder and affective disorders has not been clearly supported, but there may be a subtype genetically linked to affective disorders. Evidence of genetic influence is mixed for obsessive-compulsive personality disorder. In general, greater attention to dimensional phenotypic measures and multivariate designs can yield more definitive answers regarding the correct subtyping and probable etiology of personality disorders.
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PMID:Genetics of personality disorders: perspectives from personality and psychopathology research. 801 85

Twenty-eight Borderline Personality Disorder patients (BPD) (by DSM-III-R) were compared with 19 neurotic patients by consulting clinical charts and an interview. The clinical features and ego functions were examined. The results brought this conclusion: (1) Disorders of ego functions of BPD covered a wide range, and were especially noted in object relations. Brief psychotic experiences, depressive experiences, and impulsiveness were the characteristics of the clinical features of BPD. An examination chiefly from the viewpoint of ego functions brought two more conclusions: (2) BPD could be partly included in the schizophrenia spectrum and the affective disorder spectrum, (3) BPD can be divided into two: (a) A Core Group with impulsiveness, (b) A Serious Group with impulsiveness, and brief psychotic experiences and/or depressive experiences.
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PMID:A study of borderline personality disorder from the viewpoint of ego functions. 820 90

This article delineates the conceptual models used when medications are prescribed for patients with personality disorders and reviews the data on the efficacy of these medications. Studies before 1980 are difficult to interpret because of changes in diagnostic criteria. Nonetheless, early studies on non-DSM-III disorders such as pseudoneurotic schizophrenia, emotionally unstable character disorder, hysteroid dysphoria, and subaffective disorders indicated the potential utility of pharmacotherapy for treating personality disorders. Models to consider in evaluating the possible use of medications for treating personality disorders are: (1) treating the disorder itself; (2) treating symptom clusters within and across disorders; and (3) treating associated axis I disorders. Among the current personality disorders, borderline personality disorder has been the most extensively studied, with antipsychotic agents being the most well-documented treatment. Monoamine oxidase inhibitors, fluoxetine, and carbamazepine show promise. Schizotypal disorders may respond to low-dose antipsychotic drugs. Although heuristically valuable, the symptom cluster approach to treatment has not yet been validated. Axis I disorders, especially depression, are frequently associated with all personality disorders. Dependent personality disorder is linked to panic disorder with agoraphobia, whereas avoidant personality disorder is associated with social phobia and panic. In general, pharmacotherapy for axis I disorders is less effective in the presence of a comorbid personality disorder. Despite the modest benefits seen in many studies, pharmacotherapy can add significantly to the overall treatment of those with personality disorders. Future research must carefully assess the effect of comorbid axis I disorders on responses. The symptom cluster/psychobiologic dimension approach should be investigated in clinical studies.
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PMID:Pharmacotherapy of personality disorders: conceptual framework and clinical strategies. 822 92

A review of the published case reports of adverse behavioral episodes or unexpected psychopathology in patients taking benzodiazepines was undertaken in an attempt to determine if these adverse or unexpected events are more likely to occur with alprazolam when compared with other currently marketed benzodiazepines. Adverse behavioral phenomena and unexpected psychopathology were divided into the following categories: (1) anger or violence, (2) impulsive, suicidal, or self-harming behavior, (3) depression, (4) mania, (5) schizophrenia, (6) withdrawal syndromes and (7) physical dependence and abuse liability. It is difficult to draw conclusions from this literature because of the limitations of spontaneously reported cases and the lack of epidemiologic studies. Despite these limitations, it appears that some differences between alprazolam and older benzodiazepines may exist. The older benzodiazepines are more commonly reported to have adverse events than alprazolam (with the exception of mania or hypomania). On the other hand, worsening in post-traumatic stress disorder and an increase in impulsive behavior in patients with borderline personality disorder have only been reported in patients receiving alprazolam. This is probably explained by the fact that only alprazolam has been used to any great extent in these conditions.
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PMID:Adverse behavioral events reported in patients taking alprazolam and other benzodiazepines. 826 90

There has been much research on the biological markers of borderline personality disorder (BPD) in the last three years. The Dexamethasone Suppression Test, the Thyrotropin-Releasing Hormone Test and sleep studies no longer indicate that BPD is related to depression, although there is probably an affective subgroup. There may be evidence that some subgroups of BPD overlap with schizophrenia. An extensive analysis of serotonin studies provides exciting new directions for understanding suicidal, aggressive and especially impulsive traits.
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PMID:Biological markers in borderline personality disorder: new perspectives. 845 32


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