Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The immune system is proposed as the key to understanding the etiology and treatment of psychosocial disease. There is a dense communication network between the immune system and the central nervous system (CNS). Immune cell cytokines, via direct action on the CNS, induce fever, alter sleep, pain perception and pituitary hormone release and reduce appetite and activity in animals. Interleukin-2 and interferon given to humans result in global behavioral and cognitive pathology. Activation of the immune system by pathogens produces global cognitive and behavioral pathology also. Recently, controlled trials have demonstrated that diet can cause psychosocial disease, presumably by an immune mechanism. Immune system abnormalities have been identified in manic-depressive psychosis, schizophrenia and alcoholism. Lithium carbonate is not only prophylactic for all three of these diseases, but it also powerfully stimulates the immune system. This is proposed as the mechanism of lithium's therapeutic effect. The antipsychotics, haloperidol and the phenothiazines, affect the immune system also. The rapid development of AIDS dementia complex can be explained by the remarkable influence the immune system has on the CNS.
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PMID:The immune system is a key factor in the etiology of psychosocial disease. 205 27

The recurrent psychoses, rather than, as Kraepelin supposed, constituting 2 major entities, manic depressive illness and schizophrenia, as separate diseases, may be distributed along a continuum that extends from unipolar depressive illness through bipolar and schizoaffective psychosis to schizophrenia with increasing severities of defect state. It is proposed that this continuum rests on a genetic base, variations in the form of the gene accounting for variations in form of psychosis. The simplest interpretation of the continuum is that such variation relates to changes at a single genetic locus. Evidence from a postmortem study of brain structure in schizophrenia suggests that this is the gene that determines the development of asymmetries in the human brain, i.e., the cerebral dominance gene or right shift factor of Annett; a possible genomic location is in the pseudoautosomal region of the sex chromosomes.
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PMID:Nature of the genetic contribution to psychotic illness--a continuum viewpoint. 219 40

The authors analyzed post-partum psychoses treated at the Psychiatric Clinic of the Faculty Hospital in 1985-1986. The group comprised 41 patients. Post-partum psychoses are not considered a separate nosological unit nor symptomatic mental disorders but are classified as endogenous psychoses, provoked by childbirth. As to endogenous psychoses, most frequently manic depression is involved, as suggested by the clinical picture and course. Schizophrenia is found less frequently, as compared with manic depression, the cca 1:10. In rare instances post-partum symptomatic psychosis may develop.
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PMID:[Clinical problems in postpartum psychoses]. 222 98

Investigations of the grief reactions experienced by families when a relative develops a serious mental illness have been hampered by the lack of an appropriate instrument to measure such reactions. The authors devised the Mental Illness Version of the Texas Inventory of Grief, adapted from the Texas Revised Inventory of Grief, to assess family members' initial and present feelings about their relative's loss of mental health. A test of the instrument with 58 family members of patients with schizophrenia or bipolar disorder revealed a surprisingly low level of initial grief but higher levels of present grief.
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PMID:A preliminary study of unresolved grief in families of seriously mentally ill patients. 227 25

30 inpatients diagnosed with schizophrenia were compared to 35 inpatients with bipolar affective disorder, manic type, on a large group of neuropsychological measures. Separate factor analyses were performed on measures of verbal, spatial, and speed variables in order to generate summary scales. Controlling for the effects of age, education, sex, duration of illness, number of previous hospitalizations, and medications at time of testing, there were no significant differences between diagnostic groups on the three factors or on individual test variables. Patients on medication performed more poorly on speed variables than those off medication. These findings call into question the notion of differential patterns of cognitive deficit among psychotic diagnoses.
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PMID:Failure to differentiate bipolar disorder from schizophrenia on measures of neuropsychological function. 227 87

Two cases of electroconvulsive therapy (ECT) in adolescence are presented and the literature on the use of ECT in childhood and adolescence is reviewed. ECT was effective in children and adolescents with bipolar disorder and depression. Inadequate information exists to make a judgment regarding schizophrenia, delirium, and anorexia nervosa. ECT is not effective in autism and chronic organic brain syndromes. Complications cited include organicity and seizures in the period immediately after ECT, anxiety reactions, and disinhibition. Long-term memory deficit or cognitive impairment has not been found, although further research to rule out residual impairment is needed.
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PMID:A review of ECT for children and adolescents. 222 48

During the course of a family-interview study of probands with psychotic disorders, the authors encountered two pedigrees in which schizophrenic individuals had first-degree relatives with bipolar disorder. The authors describe the members of both families in detail and discuss several hypotheses that might account for the co-occurrence of schizophrenia and bipolar disorder in the same family.
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PMID:Schizophrenic individuals with bipolar first-degree relatives: analysis of two pedigrees. 221 56

A major innovation of the ICD-10 draft is provision of diagnostic guidelines. This is assumed to be appropriate for use in clinical situations. In Norway a similar approach was adopted when ICD-9 was introduced as the official classification system in 1987. This was done in order to avoid national diagnostic bias and increase diagnostic reliability. A comparison with the DSM-III criteria was included in the diagnostic guidelines. The effectiveness of this approach was investigated by comparing the chart ICD-9 diagnoses of 104 psychiatric in- and outpatients from 2 teaching hospitals with the diagnoses obtained by using case record rating forms (criterion diagnosis). According to the criterion diagnoses, the base rate of chart diagnoses of schizophrenia and manic-depressive psychosis was too low, and the base rate of reactive psychosis too high. Several chart diagnoses proved to have low reliability, particularly reactive psychosis, paranoid psychosis, depressive neurosis and personality disorders. The study suggests that the provision of extensive diagnostic guidelines does not necessarily alter previous diagnostic practice. Reasons for these findings and the implications for the ICD-10 diagnostic criteria and diagnostic guidelines are discussed.
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PMID:Coding guidelines for ICD-9 section on mental disorders and reliability of chart clinical diagnoses. 233 Aug 31

Admissions to a mother-baby unit in a psychiatric hospital were reviewed over a 51 month period. Forty-four mothers (3 admitted twice) and 44 babies were admitted. Eighteen women were diagnosed as having major depression (1 admitted twice), 14 with schizophreniform psychosis, 8 with schizophrenia (2 admitted twice), 4 with bipolar disorder, 2 with anxiety disorders and in 1 diagnosis was deferred. Data are presented from these women's background and that related to pregnancy, as well as duration of stay and treatment in the unit. A description of the unit is also included.
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PMID:Review of a mother-baby unit in a psychiatric hospital. 233 79

The prediction of risk for mental illnesses that have a strong genetic basis has usually been carried out by employing empirically derived estimates of recurrence observed in family studies. Because systematic methods of mapping the human genome with DNA polymorphisms have been developed it is possible that prenatal prediction of certain mental illnesses may eventually become a more accurate method of risk prediction than the empirical method currently used. Recombinant DNA technology as used in genetic linkage studies can also specify a mode of genetic transmission and lead on to aetiological studies of the disorder. The latter will result from the molecular cloning and sequencing of the responsible genetic mutations. The use of recombinant DNA technology has enabled single-gene effects to be found in schizophrenia, manic depression and Alzheimer's disease. In highly selected families it is now possible to calculate the risk of developing certain mental illnesses by DNA testing before birth. Failure to find linkages in separate schizophrenia, manic depression and Alzheimer's disease family samples has also been reported, indicating that there is heterogeneity of linkage with genes at several distinct genetic loci that contribute susceptibility to very similar clinical disorders. Resolution of the degree to which there is heterogeneity of linkage and a further examination of the factors which influence the variable effects of the abnormal genes predisposing to mental illness will both be necessary before accurate risk prediction can become feasible.
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PMID:Recent advances in the genetics of psychiatric disorder. 233 24


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