Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The interrater reliability of the Structured Clinical Interview for DSM-III-R (SCID) was studied. Fifty-four audiotaped SCID interviews were rated independently by 3 raters. The highest interrater agreements were observed for schizophrenia (0.94), major depressive disorder (0.93), dysthymia (0.88), generalized anxiety disorder (0.95), panic disorder (0.88), alcohol use disorder (0.96) and other psychoactive substance use disorder (0.85). The remaining diagnoses of mood and anxiety disorders obtained acceptable interrater agreement (0.70-0.80), with an exception for obsessive-compulsive disorder (0.40). The poorest agreement was obtained for somatoform disorders ( -0.03). Lack of hierarchy in DSM-III-R allows for multiple Axis I diagnoses. Interrater reliability for multiple diagnoses was tested. Agreement was generally good for combinations of 2 diagnoses, and poorer when 3 diagnoses were combined. Our findings confirm that SCID yields highly reliable diagnoses. SCID is recommended for research on mental disorders.
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PMID:High interrater reliability for the Structured Clinical Interview for DSM-III-R Axis I (SCID-I). 195 Jun 12

In the Upper Bavarian Field Study a total of 1536 persons (15 years and older) were interviewed by research psychiatrists. 8.1% of all respondents took a psychotropic drug during the 7 days prior to the interview. The consumption rate among women was about three times as high as that for men. The use of psychotropic drugs increased with age. No consistent pattern was found with respect to social class. According to psychiatric/physical health status the highest consumption rate (29.4%) was found among those suffering solely from psychiatric disorders. The simultaneous occurrence of both psychiatric and physical disorder did not increase the risk of drug taking (21.4%). Less than 5% of the healthy respondents and of those suffering solely from a physical disorder used psychotropic drugs. A large proportion (63.0%) of those with previous psychiatric in- and outpatient treatment received psychotropic medication, as well as those suffering from schizophrenia (66.7%), affective psychoses (52.6%) and anxiety disorders (50.0%). The higher consumption of psychotropic drugs among women could not be explained by higher psychiatric or physical morbidity or the fact that women consult primary care physicians more frequently than do men. Controlling for co-morbidity and annual consultation of family physicians, significant sex differences in the consumption of psychotropic drugs persist.
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PMID:Psychiatric and physical illness, sociodemographic characteristics, and the use of psychotropic drugs in the community: results from the Upper Bavarian Field Study. 199 90

Positron emission tomography (PET) allows high-resolution, three-dimensional evaluation of regional brain metabolic activity and neurotransmitter function. This imaging technique has been applied increasingly in psychiatric research and may yield new information regarding the neural mechanisms of several mental disorders. This article is an overview of PET studies conducted on schizophrenia, affective disorders, and anxiety disorders. Although this research is in the preliminary stage with some inconsistent findings, general trends have emerged that clearly warrant further investigation. These trends are discussed in light of relevant methodological and theoretical issues. Potential directions for future PET research are reviewed.
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PMID:Positron emission tomography in neuropsychiatry. 205 21

Projections for the prevalence of psychiatric disorders were calculated for the estimated population between 17 and 64 years of age in Puerto Rico for the year 2000. These projections were based on the results of an epidemiologic research study conducted in 1984 using a community based sample and the population estimate for the year 2000. The psychiatric disorders included affective and anxiety disorders, somatization, schizophrenic disorders, and alcohol abuse and/or dependence. The prevalence of each of these disorders will increase by the year 2000. The prevalence of affective and anxiety disorders, in particular, will have a relative increase of 5%. The simultaneous increase in the prevalence of psychiatric disorders and the increase in the population will have the combined effect of increasing the number of expected psychiatric cases by 25%.
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PMID:[Projections for the prevalence of psychiatric disorders. Puerto Rico, year 2000]. 208 53

It is becoming increasingly recognized that one third to one half of children diagnosed as having attention deficit/hyperactivity disorder (ADHD) continue to exhibit symptoms of the disorder into adulthood. The nature of the clinical picture is not well understood by a substantial number of clinicians. The purpose of this study is to report on the demographic and clinical profile of 56 adults, age 19 to 65 years (48 men, eight women) who present with adult ADHD and meet DSM-III-R criteria for the disorder. Patients underwent a diagnostic work-up consisting of medical and psychiatric evaluation, a structured interview Schedule for Affective Disorders and Schizophrenia-Lifetime Version [SADS-L]), the Symptoms Checklist Revised (SCL-9OR), Conners Attention Deficit Disorder With Hyperactivity (ADDH) scale, structured interview of ADDH, the Global Assessment of Functioning Scale (GAF), and, when available, information from parents was obtained. Ninety-one percent of our sample met the Utah Criteria for adult ADHD. The majority of the sample had additional DSM-III-R diagnoses and only seven had ADHD diagnosis alone. Fifty-three percent of the sample met the criteria for generalized anxiety disorder, 34% alcohol abuse or dependence, 30% drug abuse, 25% dysthymic disorder, and 25% cyclothymic disorder. These findings were similar to those reported in the literature.
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PMID:A clinical and demographic profile of a sample of adults with attention deficit hyperactivity disorder, residual state. 222

In view of the fact that substantial evidence today links psyche, brain, stress and immune system, the serum immunoglobulin (viz. IgG, IgA, IgM) levels in 40 patients with psychiatric disorders (viz. Schizophrenia, Affective disorder and generalized Anxiety disorders) have been investigated. With the exception of IgA, all psychiatric patients had significantly elevated IgG, IgM levels (p less than 0.001) when compared with healthy controls. Surprisingly these immunoglobulin levels irrespective of prevalent psychiatric disorder were almost similar to those of the hospitalized surgical patients pre-operatively (preferable controls), suggestive of no direct linear causal relationship between the psychiatric disorder and serum immunoglobulin levels. Factors affecting immunoglobulins have been discussed. Considering a probable viral association in Schizophrenia it is felt that simultaneous monitoring of viruses (affecting the nervous system) in the form of antigen/antibodies may be more informative.
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PMID:Serum immunoglobulin status of psychiatric in-patients. 225 Sep 80

Clinicians who treat individuals with personality disorders must remain alert to the presence of concurrent mood disorders, anxiety disorders; or schizophrenia. Comorbid disorders can significantly affect a patient's presentation, treatment, and prognosis.
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PMID:Comorbidity of personality disorders: two for the price of three. 227 7

Admissions to a mother-baby unit in a psychiatric hospital were reviewed over a 51 month period. Forty-four mothers (3 admitted twice) and 44 babies were admitted. Eighteen women were diagnosed as having major depression (1 admitted twice), 14 with schizophreniform psychosis, 8 with schizophrenia (2 admitted twice), 4 with bipolar disorder, 2 with anxiety disorders and in 1 diagnosis was deferred. Data are presented from these women's background and that related to pregnancy, as well as duration of stay and treatment in the unit. A description of the unit is also included.
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PMID:Review of a mother-baby unit in a psychiatric hospital. 233 79

This paper reports the results of a pilot study of the lifetime prevalence of psychiatric disorders in a group of nonalcoholic men with multigenerational family histories of alcoholism (high-risk) in comparison with that of a control group (nonalcoholic men without multigenerational family histories of alcoholism). Diagnoses were given following the structured interview format of the Schedule for Affective Disorders and Schizophrenia, using the Research Diagnostic Criteria. The prevalence of psychopathology in the probands' first- and second-degree relatives was also determined using the Family History Research Diagnostic Criteria. The results showed a higher lifetime prevalence of psychopathology for the high-risk men compared with control subjects, with the diagnoses of major affective disorder and anxiety disorder predominating. In addition, the data obtained from first- and second-degree relatives indicated a significantly higher prevalence of nonalcoholic diagnoses in the high-risk families (depression in particular), suggesting that alcoholism and depression may be cosegregating in these families. The lifetime prevalence of these disorders is similar to that reported in chronic alcoholics.
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PMID:The lifetime prevalence of psychopathology in men with multigenerational family histories of alcoholism. 238 Jun 95

Lifetime prevalence rates were calculated for comorbid psychiatric disorders in 119 patients who were referred from primary care physicians for unexplained somatic complaints and who met DSM III-R criteria for somatization disorder. Comparisons were made with general population norms from the ECA study. Prevalence of nine comorbid conditions was significantly higher than in the general populations. The most prevalent comorbid diagnoses were major depression (54.6%), generalized anxiety disorder (33.6%), and phobic disorders (31.1%). The least common comorbid disorders were mania (4.2%) and drug abuse (4.9%); drug abuse prevalence rates did not significantly exceed general population estimates. Risk ratios were highest for panic disorder (16.25), major depression (9.41), schizophrenia (7.77), and obsessive-compulsive disorder (7.04).
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PMID:Psychiatric comorbidity in primary care somatization disorder. 239 95


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