Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Studies have demonstrated that police often arrest the mentally ill when treatment alternatives would be preferable but are unavailable. Thus, jails may contain disproportionate numbers of severely mentally ill persons who have co-occurring disorders. Data on the co-occurrence of severe mental disorder, substance abuse, and antisocial personality disorders were gathered from 728 randomly selected male urban jail detainees. Using difference of proportions tests and loglinear analysis, the authors demonstrated that most subjects with a severe mental disorder (schizophrenia or a major affective disorder) also meet criteria for a substance abuse or antisocial personality disorder. These findings suggest several changes in public policy regarding health care delivery in correctional settings and for the general population.
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PMID:Co-occurring disorders among mentally ill jail detainees. Implications for public policy. 174 71

Children with conduct disorder have long been known to be at high risk for developing externalizing disorders, alcohol and drug abuse, and antisocial personality. Relationships of conduct disorder to other adult psychiatric disorders, on the other hand, have not been definitively shown. Taking advantage of the large community sample (N = 19,482) interviewed in the NIMH Epidemiologic Catchment Area Program, the authors examined the effects of childhood conduct problems on ten DSM-III psychiatric disorders: somatization, phobia, panic, obsessive-compulsive, depression, mania, alcohol use disorder, drug use disorder, schizophrenia and antisocial personality. Each of the ten adult disorders showed an increase in prevalence with an increasing number of conduct problems, although effects were stronger for externalizing disorders. The predictive power of conduct problems was similar for males and females. The effect of conduct problems on nonexternalizing disorders was found to be largely mediated through externalizing disorders, particularly for men but direct effects also occurred for both sexes. These findings raise questions about the conventional view of psychiatric disorders as divisible into externalizing and internalizing disorders. They also suggest that the increasing rates of conduct problems in younger cohorts may be responsible in part for the rising rates of other disorders. Thus, prevention of and early intervention with conduct disorder may hold promise for reducing rates of a broad range of disorders.
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PMID:Adult disorders predicted by childhood conduct problems: results from the NIMH Epidemiologic Catchment Area project. 185 46

In spite of available pharmacologic therapy that controls even the most severe cases of asthma, the mortality rate from asthma continues to rise. Patients with potentially fatal asthma (PFA) must be identified and then treated in a manner that will prevent potentially fatal episodes of asthma. Such management will not result in control of patients with PFA when the patient is not compliant with the medical regimen. We report and classify ten PFA patients according to the apparent psychologic abnormality that resulted in, or contributed to the noncompliance. Some of these psychologic abnormalities in patients with PFA such as adolescent noncompliance, prednisonephobia or bipolar affective disorders may be responsive to a combination of medical and psychiatric management. Other psychiatric diseases that may occur in patients with PFA, such as antisocial personality disorders or schizophrenia, may have a poor prognosis even with combined medical and psychiatric care. The managing physician should be aware of the grave prognosis in such cases.
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PMID:Potentially fatal asthma: the problem of noncompliance. 186 51

The development of psychiatry in the USSR is reviewed bearing in mind the dynamics of the main characteristics of mental patients registered at the psychoneurological dispensaries (PND). In 1965, 2188.5 thousand patients were on the books at the PND in this country, whereas in 1987, their number rose to 10201.3 thousand. Therefore, during 22 years the number of mental patients increased 4.7-fold. The greatest increase is recorded among patients suffering from schizophrenia and psychopathy. This tendency is characteristic of all the republics. At the same time the disability rate among schizophrenic patients dropped (possibly at the expense of a more favorable course of this pathology). The authors point out that this country ranks ninth in the world in the number of psychiatrists per 1000 population. As far as the number of beds for mental patients is concerned, it occupies the 23d place. From 1985 to 1988, the load of the dispensary psychiatrist reduced from 565 to 520 patients, i.e. it diminished by 8%. On the whole the psychiatric services render assistance to 4% of the population of this country today.
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PMID:[Psychiatric services in the USSR and their various indicators]. 196 86

Using the dopamine D2 receptor clone lambda hD2G1, Blum et al recently found that the D2/Taq I allele (A1) was present in 69% of 35 deceased alcoholics but in only 20% of an equal number of controls. To assess this association further, we evaluated the D2/Taq I polymorphism and a single-strand conformation polymorphism detected by polymerase chain reaction and nondenaturing gel electrophoresis (PCR-SSCP) of the 3' noncoding region of the D2 receptor gene. We studied 40 unrelated white alcoholics, 127 racially matched controls, and two white pedigrees. The Schedule for Affective Disorders and Schizophrenia-Lifetime Version (SADS-L) clinical diagnostic interviews were rated blindly by two clinicians. The SADS-L interviews and other data were then used to ascertain diagnoses according to the Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition (DSM-III-R) criteria. Alcoholics were subtyped according to age of onset, severity, presence of antisocial personality, and family history. No significant differences in either D2/Taq I or PCR-SSCP allele frequencies were observed between alcoholics, subpopulations of alcoholics, or controls. The PCR-SSCP polymorphism provided independent information against linkage at the D2 receptor locus. Several recombinants between the D2/Taq I locus and alcoholism were observed in two white families with an alcoholic parent who possessed the A1 allele. This study does not support a widespread or consistent association between the D2 receptor gene and alcoholism.
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PMID:Population and pedigree studies reveal a lack of association between the dopamine D2 receptor gene and alcoholism. 182 66

This paper summarizes and discusses the contributions of neuropsychological assessment to various forms of psychopathology. Emphasis is placed upon studies done with the Halstead-Reitan battery and the Wechsler Adult Intelligence Scale, but studies done with other neuropsychological test procedures are also reviewed. The conclusions reached are that neuropsychological tests are sensitive to functional regional brain disorganization in psychopathology, and that they are useful in the diagnostic process for a number of disorders including schizophrenia, psychopathy, mood disorders, and other psychiatric conditions.
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PMID:Neuropsychology and psychopathology: a progress report. 215 27

Combined clinical, psychologic and neurophysiological investigation was conducted in children with slow-progredient schizophrenia: with dominant affective disorders and hypomaniac states (Group I, 14 patients), and with predominant neurosis-like and psychopathy-like pathology (Group II, 12 patients). The patients distinctly differed in not only the clinical course of the disease but also according to neuropsychological investigations of memory, pathopsychological and EEG studies. These data are reliably intercorrelated. A high incidence of visual mnestic, marked perception disorders, and frequent focal signs of lesion of parieto-occipital cortex with cortical irritation were all characteristics of the Group I. In Group II a high inhibitability of the traces characteristic of the diencephalic-brainstem dysfunction, predominant impairment of objective-substantional thinking and the symptoms of brainstem irritation were marked.
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PMID:[Neuropsychological study of memory in the complex clinical, psychological and neurophysiologic examination of children with schizophrenia]. 215 7

The evidence indicating that the forms of schizophrenia in men and women represent different morbid states is reviewed. Age of onset and gender are considered to be of fundamental importance in determining the different symptomatological and evolutionary features of the syndrome in the two sexes. Early-onset forms in males are associated with chronicity, absence of familial predisposition for psychosis, and the presence of structural cerebral pathology specifically involving the dominant hemisphere. Later onset forms in females are characterized by more florid symptoms, more affective features, more familial psychosis, and more favorable outcome with no or less pronounced structural cerebral involvement. It is argued that these differential characteristics derive from the differential hemispheric organization of the male and female brain--which also determines the male susceptibility to other psychopathological syndromes such as psychopathy and sexual deviations as well as the excess in women of schizoaffective states, affective disorders, and late-onset schizophrenia.
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PMID:Influence of gender in schizophrenia as related to other psychopathological syndromes. 219 14

The prevalence of comorbid alcohol, other drug, and mental disorders in the US total community and institutional population was determined from 20,291 persons interviewed in the National Institute of Mental Health Epidemiologic Catchment Area Program. Estimated US population lifetime prevalence rates were 22.5% for any non-substance abuse mental disorder, 13.5% for alcohol dependence-abuse, and 6.1% for other drug dependence-abuse. Among those with a mental disorder, the odds ratio of having some addictive disorder was 2.7, with a lifetime prevalence of about 29% (including an overlapping 22% with an alcohol and 15% with another drug disorder). For those with either an alcohol or other drug disorder, the odds of having the other addictive disorder were seven times greater than in the rest of the population. Among those with an alcohol disorder, 37% had a comorbid mental disorder. The highest mental-addictive disorder comorbidity rate was found for those with drug (other than alcohol) disorders, among whom more than half (53%) were found to have a mental disorder with an odds ratio of 4.5. Individuals treated in specialty mental health and addictive disorder clinical settings have significantly higher odds of having comorbid disorders. Among the institutional settings, comorbidity of addictive and severe mental disorders was highest in the prison population, most notably with antisocial personality, schizophrenia, and bipolar disorders.
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PMID:Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. 1114 82

Previous studies that have assessed a stimulation-seeking theory of psychopathy are open to the criticism that psychopaths may lie on self-report questionnaires. The present study uses event-related potential (ERP) augmenting-reducing as a psychophysiological analog of stimulation-seeking in psychopaths to test this theory. It is also hypothesized that "schizoid" criminals, as defined by poor eye tracking, would show nonaugmenting/reducing, a profile characteristic of schizophrenia. Schizoid criminals were found to be characterized by nonaugmenting/reducing, but psychopaths were not found to be characterized by augmenting. It is concluded that stimulation-seeking is a viable theory of criminality but not of psychopathy, and that the etiological basis to schizoid criminality may differ substantially from criminality, per se.
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PMID:Evoked potential augmenting-reducing in psychopaths and criminals with impaired smooth-pursuit eye movements. 231 24


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