Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0036341 (schizophrenia)
 60,220 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Genital self-mutilation is a rare severe form of self-injurious behaviour usually described in psychotic disorders with delusions & hallucinations. It has been ascribed to sexual conflicts, body image distortion, internalized aggression and suicidal intent. This phenomenon has been described in schizophrenia, affective psychosis, alcohol intoxication and personality disorders. In the present case genital self-mutilation in a case of Major-Depressive Disorder in an 82 yrs old male is being reported and psychosocial factors are discussed. This case has some unusual features.
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PMID:Genital self-mutilation in depression: a case report. 2120 88

Sleep and circadian rhythm disruption has been widely observed in neuropsychiatric disorders including schizophrenia [1] and often precedes related symptoms [2]. However, mechanistic basis for this association remains unknown. Therefore, we investigated the circadian phenotype of blind-drunk (Bdr), a mouse model of synaptosomal-associated protein (Snap)-25 exocytotic disruption that displays schizophrenic endophenotypes modulated by prenatal factors and reversible by antipsychotic treatment [3, 4]. Notably, SNAP-25 has been implicated in schizophrenia from genetic [5-8], pathological [9-13], and functional studies [14-16]. We show here that the rest and activity rhythms of Bdr mice are phase advanced and fragmented under a light/dark cycle, reminiscent of the disturbed sleep patterns observed in schizophrenia. Retinal inputs appear normal in mutants, and clock gene rhythms within the suprachiasmatic nucleus (SCN) are normally phased both in vitro and in vivo. However, the 24 hr rhythms of arginine vasopressin within the SCN and plasma corticosterone are both markedly phase advanced in Bdr mice. We suggest that the Bdr circadian phenotype arises from a disruption of synaptic connectivity within the SCN that alters critical output signals. Collectively, our data provide a link between disruption of circadian activity cycles and synaptic dysfunction in a model of neuropsychiatric disease.
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PMID:Disrupted circadian rhythms in a mouse model of schizophrenia. 2226 13

Genital self mutilation is a rare and a severe form of self-injurious behavior usually described in psychotic disorders, with delusions and hallucinations. It has been ascribed to sexual conflicts, Body image distortions, Internalized aggression, and suicidal intent. This phenomenon has been described in schizophrenia, affective psychosis, alcohol intoxication, and personality disorders. The present case genital self mutilation in a case of alcohol withdrawal state complicated by delirium is reported.
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PMID:Genital self mutilation in alcohol withdrawal state complicated with delirium. 2234 48

For schizophrenia patients, early diagnosis and comprehensive treatment can improve outcomes, according to mental health experts. And the first opportunity to intervene often occurs in an emergency setting. To help ED staff connect these patients to appropriate care quickly, the ED at the University of Alabama at Birmingham Medical Center has opened the First Episode Schizophrenia Clinic, one of only a few such care settings in the country. While most EDs don't have this type of resource available, experts suggest staff would benefit from regular education about the signs and symptoms of the disease, and they urge ED administrators and clinicians to foster relationships with outside mental health providers so suspected schizophrenia patients can be transitioned to appropriate care quickly. Onset of schizophrenia most often occurs during the teenage years. Patients may present with depressive symptoms, or they may be acting odd or reclusive. Other potential causes, such as substance abuse or alcohol intoxication, need to be excluded before a definitive diagnosis of schizophrenia can be made. Experts advise ED clinicians to make sure they communicate effectively with outside mental health providers when making a patient referral. The mental health provider needs to understand what workups were completed in the ED, and what conditions the ED staff are concerned about. Patients often fail to report why they have been referred.
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PMID:For improved outcomes, connect first-episode schizophrenia patients to comprehensive care quickly. 2294 77

Self-inflicted abdominal stab wounds are generally uncommon and there is no published report of survivors after extensive self inflicted disembowelment with mutilation. Here we present a case of 28 year old male who was brought to hospital 2 1/2 h after disembowelment through self inflicted abdominal stab injuries. The patient had hypovolemic shock due to bleeding from the mesentery and a 450 cm segment of small bowel which had been pulled out from 2 abdominal stab wounds and slashed multiple times by him. He had alcohol intoxication and hallucinations and did not seem to be in pain or emotionally affected by the severe injury. After resuscitation, and emergency resection with anastomosis he had an uneventful post-operative recovery. On psychiatric evaluation during follow-up, he was found to have schizophrenia aggravated by alcohol abuse and was treated accordingly. As self mutilation can be the first presentation of a psychotic episode, a psychiatric evaluation is necessary for all patients with self inflicted injuries.
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PMID:Successfully treated bizarre self-mutilation with disembowelment--case report with review of literature. 2391 Aug 38


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