Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0035412 (rhabdomyosarcoma)
 6,156 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A serious problem for every pathologist is how to avoid making errors in histopathological diagnosis. Five cases which I misdiagnosed or nearly did were reviewed, and the ways to avoid making errors were discussed. The first case was clinically a gastric carcinoma. In the biopsy of gastric mucosa, I took a lymphoepithelial lesion for poorly differentiated adenocarcinoma. In the surgical specimen, the histological diagnosis was malignant lymphoma. The second case was a tumor of cecum. Clinically cecal cancer was suspected and operated due to the complication of invagination. Histological examination of cecal tumor revealed marked lymphocytic infiltration with plasma cells. The immunohistochemistry showed a mixed pattern of B- and T-lymphocytes with monoclonal proliferation of plasma cells (IgA, Kappa). Because an inflammatory polyp could not be ruled out, it was offered to consultation. The diagnosis was malignant lymphoma, lymphoplasmacytoid type. The third case was a neck tumor. Although histological diagnosis at first was undifferentiated carcinoma, immunohistochemically tumor cells were unexpectedly negative for epithelial membrane antigen and positive for creatine kinase-mm. Finally it was diagnosed as rhabdomyosarcoma. The fourth case was a struma nodosa. In the frozen section, it was diagnosed as follicular adenoma. However, in the permanent section, the diagnosis was corrected to papillary carcinoma, follicular type, because many intranuclear inclusions were clearly observed. The last case was a finger tumor. Since hemangiosarcoma could not be histologically ruled out, it was offered to consultation. The diagnosis was intravascular papillary endothelial hyperplasia. In conclusion, I emphasize the importance of consultation in order to avoid making errors in histopathological diagnosis.
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PMID:[Review of the misdiagnosed cases focusing on the quality control of histopathological diagnosis]. 796 14

Two infants with fibrosarcoma and rhabdomyosarcoma diagnosed prenatally and at 2 months of age, respectively, and cytomegalovirus (CMV) infection are reported. Concomitant CMV infection was revealed by positive urine culture and/or CMV DNA, and CMV-specific IgM, IgA, and complement-fixing antibodies. The patients, showing very low levels of immune T cells, died at 3 and 8 months of age, respectively. A pathogenic role for CMV in the progression of the tumors is suggested.
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PMID:Cytomegalovirus infection in two infants with congenital or neonatal solid tumors. 829 21

In this first article of a series of papers listing first case reports of animal diseases published since 2000, the following 19 cases of dog diseases are discussed: Blastomycotic granuloma involving the cranial vena cava. Congenital myocardial hamartoma. Discospondylitis: three cases caused respectively by Pseudomonas aeruginosa, Enterococcus faecalis and Staphylococcus epidermidis. Dystrophin deficient muscular dystrophy in a Labrador Retriever. Emphysematous prostatitis. Erythema multiforme major caused by a Parvovirus infection of keratinocytes. Hemochromatosis due to repeated blood transfusions. Intraspinal synovial cyst. Juvenile nephropathy in the Collie and the Irish Wolfhound. Primary cerebellar cortical degeneration (abiotrophy) in a Scottish terrier. Primary pulmonary artery chondrosarcoma. Renal dysplasia in a Bull Mastiff. Rhabdomyosarcoma (botryoid sarcoma) of the urinary bladder in a Maltese. Spinal mast cell tumor. Spongiform degeneration of the white matter in the central nervous system of Australian Cattle dog. Systemic pasteurellosis caused by Pasteurella canis. Thymic hemorrhage caused by dicumarol intoxication. Undimerized biclonal gammopathy with a single heavy chain class IgA in a dog with multiple myeloma. After a short introduction, the bibliographical data and the abstract of the author(s) and mostly some additional information derived from the article are given. The article will be regularly updated adding overlooked as well as new first reports.
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PMID:First cases of animal diseases published since 2000. 1. Dogs. 1453 81

Enterovirus 71 (EV71) causes seasonal epidemics of hand-foot-and-mouth disease associated with fatal neurological complications in young children, and several major outbreaks have occurred recently. This study developed an effective antiviral agent by transforming the gene for VP1 protein, a previously defined epitope and also a coat protein of EV71, into tomato plant. VP1 protein was first fused with sorting signals to enable it to be retained in the endoplasmic reticulum of tomato plant, and its expression level increased to 27 microg/g of fresh tomato fruit. Transgenic tomato fruit expressing VP1 protein was then used as an oral vaccine, and the development of VP1-specific fecal IgA and serum IgG were observed in BALB/c mice. Additionally, serum from mice fed transgenic tomato could neutralize the infection of EV71 to rhabdomyosarcoma cells, indicating that tomato fruit expressing VP1 was successful in orally immunizing mice. Moreover, the proliferation of spleen cells from orally immunized mice was stimulated by VP1 protein, and provided further evidence of both humoral and cellular immunity. Results of this study not only demonstrate the feasibility of using transgenic tomato as an oral vaccine to generate protective immunity in mice against EV71, but also suggest the probability of enterovirus vaccine development.
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PMID:Oral immunization of mice using transgenic tomato fruit expressing VP1 protein from enterovirus 71. 1644 30